Drug General Information (ID: DDIIS1Q7EX)
Drug Name			Phenylephrine		Drug Info		Levothyroxine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Mydriatics/Decongestants				Antithyroid Agents
Structure

Mechanism of Phenylephrine-Levothyroxine Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Phenylephrine				Levothyroxine
Mechanism		Sympathomimetic amine				Potentiate the pharmacologic effects of sympathomimetic amine
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Phenylephrine and Levothyroxine

Recommended Action
Management		Monitoring for increased sympathomimetic effects and cardiac function may be advisable.

References
1	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
2	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
3	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."