Details of Drug

Details of Drug

 Drug General Information (ID: D1275)
  Drug Name
Phenylbutyric acid
  Drug Type Small molecule
  Drug Synonymous
Benzenebutyric acid; Phenyl butanoate; Phenyl butyrate; HDInhib_000004; Butanoic acid, phenyl ester; Butyric acid, phenyl ester; FR-2080; Gamma-Phenylbutyric acid; Omega-Phenylbutanoic acid; GAMMA-PHENYL-BUTYRIC ACID; Butyric acid, 4-phenyl-(8CI); 1-Phenylbutyric acid; 4-PHENYL-BUTANOIC ACID; 4-PHENYLBUTYRIC ACID; 4-Phenylbutanoic acid; 4-phenylbutans; 4-phenylbutyrate
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  Disease Class 5C50: Metabolism inborn error
  Therapeutic Class Antihyperammonia Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C10H12O2
  InChI 1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12)
  InChIKey OBKXEAXTFZPCHS-UHFFFAOYSA-N
  Canonical SMILES C1=CC=C(C=C1)CCCC(=O)O
  External Link
Pubchem ID 4775
CAS Number 1821-12-1
CHEBI ID 41500
TTD ID D0B7CH

Drug-Drug Interaction Network
  Sunburst Graph
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM032  Decreased renal excretion (Unspecific)
BM056  Increased risk of hyperammonemia
BM088  Antagonize the effect of anti-hyperammonemia agents
  Relation Graph
 Full list of drugs interacting with Phenylbutyric acid
      Affected excretion pathways
   Decreased renal excretion (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1341
 
Probenecid
 
C13H19NO4S
 
4911 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic additive effects
   Increased risk of hyperammonemia Drug Num:  14
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0172
 
Betamethasone
 
C22H29FO5
 
9782 
Moderate    Inter Info   
[6], [2], [3]
D0215
 
Budesonide
 
C25H34O6
 
5281004 
Moderate    Inter Info   
[6], [2], [3]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[6], [2], [3]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[6], [2], [3]
D0671
 
Fludrocortisone
 
C21H29FO5
 
31378 
Moderate    Inter Info   
[6], [2], [3]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[6], [2], [3]
D0773
 
Hydrocortisone
 
C21H30O5
 
5754 
Moderate    Inter Info   
[6], [2], [3]
D1041
 
Methylprednisolone
 
C22H30O5
 
6741 
Moderate    Inter Info   
[6], [2], [3]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[6], [2], [3]
D0436
 
Deflazacort
 
C25H31NO6
 
189821 
Moderate    Inter Info   
[6], [2], [3]
D1332
 
Prednisolone
 
C21H28O5
 
5755 
Moderate    Inter Info   
[6], [2], [3]
D1334
 
Prednisone
 
C21H26O5
 
5865 
Moderate    Inter Info   
[6], [2], [3]
D1609
 
Topiramate
 
C12H21NO8S
 
5284627 
Moderate    Inter Info   
[6], [2], [3]
D1628
 
Triamcinolone
 
C21H27FO6
 
31307 
Moderate    Inter Info   
[6], [2], [3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of anti-hyperammonemia agents Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1677
 
Valproic acid
 
C8H16O2
 
3121 
Major    Inter Info   
[4], [3], [5]
References
1 Goldbart A, Press J, Sofer S, Kapelushnik J "Near fatal acute colchicine intoxication in a child. A case report." Eur J Pediatr 159 (2000): 895-7. [PMID: 11131346]
2 Product Information. Buphenyl (sodium phenylbutyrate). Horizon Pharma USA Inc, Northbrook, IL.
3 Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
4 Product Information. Depakene (valproic acid). Abbott Pharmaceutical, Abbott Park, IL.
5 Product Information. Depakote (divalproex sodium). Abbott Pharmaceutical, Abbott Park, IL.
6 Cerner Multum, Inc. "Australian Product Information.".