Details of Drug

Details of Drug

 Drug General Information (ID: D1227)
  Drug Name
Paritaprevir
  Drug Type Small molecule
  Disease Class 1E50-1E51: Hepatitis virus infection
  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C40H43N7O7S
  InChI 1S/C40H43N7O7S/c1-24-21-42-33(22-41-24)35(48)43-32-16-6-4-2-3-5-11-25-20-40(25,39(51)46-55(52,53)27-17-18-27)45-36(49)34-19-26(23-47(34)38(32)50)54-37-30-14-8-7-12-28(30)29-13-9-10-15-31(29)44-37/h5,7-15,21-22,25-27,32,34H,2-4,6,16-20,23H2,1H3,(H,43,48)(H,45,49)(H,46,51)/b11-5-/t25-,26-,32+,34+,40-/m1/s1
  InChIKey UAUIUKWPKRJZJV-QPLHLKROSA-N
  Canonical SMILES CC1=CN=C(C=N1)C(=O)NC2CCCCCC=CC3CC3(NC(=O)C4CC(CN4C2=O)OC5=NC6=CC=CC=C6C7=CC=CC=C75)C(=O)NS(=O)(=O)C8CC8
  External Link
Pubchem ID 45110509
CAS Number 1216941-48-8
TTD ID D07OHT
VARIDT ID DR01312

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
BM010  Transporter inhibition
BM017  CYP450 enzyme inhibition
BM019  UGT inhibition
BM022  CYP450 enzyme induction
BM026  Increased metabolism (Unspecific)
  Relation Graph
 Full list of drugs interacting with Paritaprevir
      Affected cellular transport
   Transporter inhibition Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1329
 
Pravastatin
 
C23H36O7
 
54687 
Major    Inter Info   
[7], [8], [3]
D0155
 
Bempedoic acid
 
C19H36O5
 
10472693 
Moderate    Inter Info   
[10], [11], [12]
D0568
 
Enasidenib
 
C19H17F6N7O
 
89683805 
Moderate    Inter Info   
[4], [13], [10]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Major    Inter Info   
[1], [2], [3]
D1404
 
Rilpivirine
 
C22H18N6
 
6451164 
Major    Inter Info   
[9], [1], [3]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Moderate    Inter Info   
[5], [1], [3]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Moderate    Inter Info   
[5], [1], [3]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Moderate    Inter Info   
[5], [1], [3]
   UGT inhibition Drug Num:  13
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0387
 
Conjugated estrogens
 
C18H21NaO5S
 
45357473 
Major    Inter Info   
[1], [3]
D0388
 
Conjugated estrogens (topical)
 
C18H21NaO5S
 
45357473 
Major    Inter Info   
[1], [3]
D0484
 
Dienestrol (topical)
 
C18H18O2
 
667476 
Major    Inter Info   
[1], [3]
D0487
 
Diethylstilbestrol
 
C18H20O2
 
448537 
Major    Inter Info   
[1], [3]
D0606
 
Estradiol
 
C18H24O2
 
5757 
Major    Inter Info   
[1], [3]
D0607
 
Estradiol (topical)
 
C18H24O2
 
5757 
Major    Inter Info   
[1], [3]
D0609
 
Estrone
 
C18H22O2
 
5870 
Major    Inter Info   
[1], [3]
D0610
 
Estrone sulfate
 
C18H22O5S
 
3001028 
Major    Inter Info   
[1], [3]
D0611
 
Estrone sulfate (topical)
 
C18H22O5S
 
3001028 
Major    Inter Info   
[1], [3]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Major    Inter Info   
[4], [5], [3]
D0605
 
Esterified estrogens
 
NA
 
NA
Major    Inter Info   
[1], [3]
D1327
 
Prasterone enantate
 
C26H40O3
 
163331 
Major    Inter Info   
[1], [3]
D1370
 
Quinestrol
 
C25H32O2
 
9046 
Major    Inter Info   
[1], [3]
   CYP450 enzyme induction Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Major    Inter Info   
[4], [5], [6]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Moderate    Inter Info   
[5], [14]
   Increased metabolism (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Major    Inter Info   
[1], [3]
References
1 Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
2 Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
3 Product Information. Viekira Pak (dasabuvir/ombitasvir/paritaprevir/ritonavir). AbbVie US LLC, North Chicago, IL.
4 Cerner Multum, Inc. "Australian Product Information.".
5 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6 Department of Health and Human Services "Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents.".
7 Everett DW, Chando TJ, Didonato GC, Singhvi SM, Pan HY, Weinstein SH "Biotransformation of pravastatin sodium in humans." Drug Metab Dispos 19 (1991): 740-8. [PMID: 1680649]
8 Fichtenbaum CJ, Gerber JG, Rosenkranz SL, et al. "Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: ACTG Study A5047." AIDS 16 (2002): 569-577. [PMID: 11873000]
9 Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
10 Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
11 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
12 Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
13 Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
14 Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.