Drug General Information (ID: DDI5I4678L)
Drug Name			Darunavir		Drug Info		Paritaprevir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Antiviral Agents
Structure

Mechanism of Darunavir-Paritaprevir Interaction (Severity Level: Major)
Increased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Darunavir				Paritaprevir
Mechanism		Darunavir				Decrease the plasma concentrations of darunavir
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Increased metabolism of Darunavir caused by Paritaprevir

Recommended Action
Management		Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiviral drug levels, concomitant use of darunavir plus ritonavir and ombitasvir/paritaprevir/ritonavir plus dasabuvir is not recommended.

References
1	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
2	Product Information. Viekira Pak (dasabuvir/ombitasvir/paritaprevir/ritonavir). AbbVie US LLC, North Chicago, IL.