Details of Drug

Drug General Information (ID: D1217)
Drug Name	Pamidronic acid
Drug Type	Small molecule
Drug Synonymous	AHPrBP; Amidronate; Aminomux; Aminopropanehydroxydiphosphonate; Aredia; Ribodroat; Acide pamidronique; Acido pamidronico; Acidum pamidronicum; Aminohydroxypropylidene diphosphonate; Novartis brand of pamidronate disodium salt; PAMIDRONATE DISODIUM; PAMIDRONIC ACID; Pamidronate calcium; Pamidronate monosodium; Bisphosphonate 6; Acide pamidronique [INN-French]; Acido pamidronico [INN-Spanish]; Acidum pamidronicum [INN-Latin]; Pamidronic acid (INN); Pamidronic acid [INN:BAN]; Ribodroat (TN); Amino-1-hydroxypropane-1,1-diphosphonate; (3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID; (3-Amino-1-hydroxypropylidene)bisphosphonic acid; (3-Amino-1-hydroxypropylidene)diphosphonic acid; (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid; (3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid); (3-amino-1-hydroxypropylidene)-1,1-biphosphonate; (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate; 1-hydroxy-3-aminopropane-1,1-diphosphonic acid; 3-Amino-1-hydroxypropylidene-1,1-diphosphonate Click to Show/Hide
Disease Class	5B91: Mineral excesses
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C3H11NO7P2
InChI	1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
InChIKey	WRUUGTRCQOWXEG-UHFFFAOYSA-N
Canonical SMILES	C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
External Link
	Pubchem ID	4674
	CAS Number	40391-99-9
	CHEBI ID	7903
	TTD ID	D0BF8G

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM027 Decreased renal excretion due to nephrotoxicity BM054 Increased risk of GI mucosal injury/bleeding risk BM063 Increased risk of hypocalcemia BM072 Increased risk of nephrotoxicity BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Pamidronic acid
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[26]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[27]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[28]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[29]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[10], [30], [31]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[33]
Pharmacodynamic additive effects
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[8], [9]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[21], [22], [23]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[21], [22], [23]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[21], [22], [23]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[21], [22], [23]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[21], [22], [23]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[21], [22], [23]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[21], [22], [23]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[21], [22], [23]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[21], [22], [23]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[21], [22], [23]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[21], [22], [23]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[21], [22], [23]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[21], [22], [23]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[21], [22], [23]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[21], [22], [23]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[21], [22], [23]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[21], [22], [23]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[21], [22], [23]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[21], [22], [23]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[21], [22], [23]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[21], [22], [23]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[21], [22], [23]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[21], [22], [23]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[21], [22], [23]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[21], [22], [23]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[21], [22], [23]
	Increased risk of hypocalcemia					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0615		Etelcalcetide	C38H73N21O10S2	71511839	Major		Inter Info	[10], [11]
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[18], [19], [20]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[18], [19], [20]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[11], [20]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[11], [20]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[11], [20]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[18], [19], [20]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[18], [19], [20]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[18], [19], [20]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[18], [19], [20]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[18], [19], [20]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[18], [19], [20]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[18], [19], [20]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[11], [20]
	Increased risk of nephrotoxicity					Drug Num: 46
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[1], [2], [3]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[4], [5], [6]
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[7]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[4], [5], [6]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[4], [5], [6]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[4], [5], [6]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[10], [12]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[1], [2], [3]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[1], [2], [3]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[1], [2], [3]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[1], [2], [3]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[1], [2], [3]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[1], [2], [3]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[1], [2], [3]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[1], [2], [3]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[13], [14], [15]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[13], [14], [15]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[18], [19], [20]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[18], [19], [20]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[18], [19], [20]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[18], [19], [20]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[18], [19], [20]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[18], [19], [20]
D0142		Bacitracin	C66H103N17O16S	10909430	Moderate		Inter Info	[18], [19], [20]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[18], [19], [20]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[18], [19], [20]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[18], [19], [20]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[25]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Moderate		Inter Info	[18], [19], [20]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[18], [19], [20]
D0709		Gallium nitrate	GaN3O9	61635	Moderate		Inter Info	[18], [19], [20]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[18], [19], [20]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[18], [19], [20]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[18], [19], [20]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[18], [19], [20]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[18], [19], [20]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[18], [19], [20]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[18], [19], [20]
D1091		Moxetumomab Pasudotox	NA	NA	Moderate		Inter Info	[18], [19], [20]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[18], [19], [20]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[18], [19], [20]
D1310		Polymyxin B	C56H98N16O13	49800004	Moderate		Inter Info	[18], [19], [20]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[18], [19], [20]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[18], [19], [20]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[18], [19], [20]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[18], [19], [20]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0177		Bevacizumab	NA	NA	Moderate		Inter Info	[16], [10], [17]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[10], [24]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[16], [10], [17]
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[32]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[16], [10], [17]

References
1	Bentley ML, Corwin HL, Dasta J "Drug-induced acute kidney injury in the critically ill adult: recognition and prevention strategies." Crit Care Med 38(6 Suppl) (2010): S169-74. [PMID: 20502171]
2	Dubrovskaya Y, Prasad N, Lee Y, Esaian D, Figueroa DA, Tam VH "Risk factors for nephrotoxicity onset associated with polymyxin B therapy." J Antimicrob Chemother 70 (2015): 1903-7. [PMID: 25652747]
3	Kellum JA, Leblanc M, Venkataraman R "Acute renal failure." BMJ Clin Evid 9 (2008): 2001. [PMID: 19445797]
4	Guo X, Nzerue C "How to prevent, recognize, and treat drug-induced nephrotoxicity.".
5	Centers for Disease Control and Prevention (CDC). Renal insufficiency and failure associated with immune globulin intravenous therapy--United States, 1985-1998.?MMWR Morb Mortal Wkly Rep. 1999;48(24):518-521. [PMID: 10401909]
6	Product Information. BabyBIG (botulism immune globulin). FFF Enterprises, Temecula, CA.
7	Product Information. Vistide (cidofovir). Gilead Sciences, Foster City, CA.
8	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
9	Rafat C, Fakhouri F, Ribeil JA, Delarue R, Le Quintrec M "Fanconi Syndrome Due to Deferasirox." Am J Kidney Dis (2009):. [PMID: 19493602]
10	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
11	Product Information. Skelid (tilundronate). Sanofi Winthrop Pharmaceuticals, New York, NY.
12	Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
13	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
14	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
15	Sheiner PA, Mor E, Chodoff L, Glabman S, Emre S, Schwartz ME, Miller CM "Acute renal, failure associated with the use of ibuprofen in two liver transplant recipients on FK506." Transplantation 57 (1994): 1132-3. [PMID: 7513099]
16	Cerner Multum, Inc. "Australian Product Information.".
17	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
18	Chang JT, Green L, Beitz J "Renal failure with the use of zoledronic acid." N Engl J Med 349 (2003): 1676-9 discussion 1676-9. [PMID: 14573746]
19	Kanis JA, Preston CJ, Yates AJ, Percival RC, Mundy KI, Russell RG "Effects of intravenous diphosphonates on renal function." Lancet 1 (1983): 1328. [PMID: 6134112]
20	Product Information. Zometa (zoledronic acid). Novartis Pharmaceuticals, East Hanover, NJ.
21	Product Information. Actonel (risedronate). Procter and Gamble Pharmaceuticals, Cincinnati, OH.
22	Product Information. Bonefos (clodronate). Rhone-Poulenc Rorer Canada Inc, Laval, QC.
23	Product Information. Didronel I.V. Infusion (etidronate). MGI Pharma Inc, Minnetonka, MN.
24	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
25	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
26	Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.
27	Product Information. Ancobon (flucytosine). Roche Laboratories, Nutley, NJ.
28	Product Information. Eloxatin (oxaliplatin). Sanofi Winthrop Pharmaceuticals, New York, NY.
29	Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
30	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
31	Gilead Sciences, Inc "About Remdesivir.".
32	Product Information. Evenity (romosozumab). Amgen USA, Thousand Oaks, CA.
33	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.

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