Details of Drug

Drug General Information (ID: D1174)
Drug Name	Omacetaxine mepesuccinate
Drug Type	Small molecule
Drug Synonymous	Synribo (TN) Click to Show/Hide
Disease Class	2A20: Myeloproliferative neoplasm
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C29H39NO9
InChI	1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
InChIKey	HYFHYPWGAURHIV-JFIAXGOJSA-N
Canonical SMILES	CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O
External Link
	Pubchem ID	285033
	CAS Number	26833-87-4
	CHEBI ID	71019
	TTD ID	D0M4XY

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM050 Increased risk of bleeding BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Omacetaxine mepesuccinate
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 236
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[3], [4], [5]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[6], [7]
D0614		Etanercept	NA	NA	Major		Inter Info	[3], [4], [5]
D0802		Infliximab	NA	NA	Major		Inter Info	[3], [4], [5]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[8], [9]
D1111		Natalizumab	NA	NA	Major		Inter Info	[10]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[14], [6], [15]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[3], [4], [5]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[20]
D0736		Golimumab	NA	NA	Major		Inter Info	[3], [4], [5]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[6], [21]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[14], [24]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[8], [9]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[28]
D0004		Abatacept	NA	NA	Moderate		Inter Info	[2]
D0014		Acetohydroxamic acid	C2H5NO2	1990	Moderate		Inter Info	[2]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[2]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[25], [32], [33]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[2]
D0048		Altretamine	C9H18N6	2123	Moderate		Inter Info	[2]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[34], [35], [36]
D0094		Antithymocyte immunoglobulin (rabbit)	NA	NA	Moderate		Inter Info	[2]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[2]
D0134		Azacitidine	C8H12N4O5	9444	Moderate		Inter Info	[2]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[14], [6], [33]
D0147		Basiliximab	NA	NA	Moderate		Inter Info	[2]
D0148		Beclomethasone dipropionate	C28H37ClO7	21700	Moderate		Inter Info	[2]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[2]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[2]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[2]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[2]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[2]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[2]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[2]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[2]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[2]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[2]
D0306		Cetuximab	NA	NA	Moderate		Inter Info	[2]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[2]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[2]
D0333		Ciclesonide	C32H44O7	6918155	Moderate		Inter Info	[2]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[2]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[2]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[2]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[2]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[2]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[2]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[2]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[2]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[2]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[2]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[2]
D0431		Decitabine	C8H12N4O4	451668	Moderate		Inter Info	[2]
D0442		Denileukin diftitox	NA	NA	Moderate		Inter Info	[2]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[2]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[2]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[2]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[2]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[37]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[2]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[2]
D0608		Estramustine	C23H31Cl2NO3	259331	Moderate		Inter Info	[2]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[2]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[2]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[2]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[2]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[2]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[2]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[2]
D0672		Flunisolide	C24H31FO6	82153	Moderate		Inter Info	[2]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[2]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[2]
D0703		Fulvestrant	C32H47F5O3S	104741	Moderate		Inter Info	[2]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[2]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[2]
D0717		Gemtuzumab ozogamicin	NA	NA	Moderate		Inter Info	[2]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[2]
D0746		Guanidine	CH5N3	3520	Moderate		Inter Info	[2]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[2]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[2]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[2]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[2]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[2]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[2]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[2]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[2]
D0825		Interferon alfa-n3	NA	NA	Moderate		Inter Info	[2]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[2]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[2]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[2]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[2]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[2]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[2]
D0910		Levamisole	C11H12N2S	26879	Moderate		Inter Info	[2]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[2]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[2]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[2]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[2]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[2]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[2]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[2]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[2]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[2]
D1093		Muromonab	NA	NA	Moderate		Inter Info	[2]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[2]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[2]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[2]
D0027		Aflibercept	NA	NA	Moderate		Inter Info	[2]
D0091		Antilymphocyte immunoglobulin (horse)	NA	NA	Moderate		Inter Info	[2]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[2]
D0118		Atezolizumab	NA	NA	Moderate		Inter Info	[2]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[2]
D0132		Axicabtagene ciloleucel	NA	NA	Moderate		Inter Info	[2]
D0150		Belantamab mafodotin	NA	NA	Moderate		Inter Info	[2]
D0151		Belatacept	NA	NA	Moderate		Inter Info	[2]
D0152		Belimumab	NA	NA	Moderate		Inter Info	[2]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[2]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[2]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[2]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[2]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[2]
D0203		Brexucabtagene autoleucel	NA	NA	Moderate		Inter Info	[2]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[2]
D0209		Brodalumab	NA	NA	Moderate		Inter Info	[2]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[2]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[2]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[2]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[2]
D0422		Daratumumab	NA	NA	Moderate		Inter Info	[2]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[2]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[33], [51]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[2]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[2]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[2]
D0540		Dupilumab	NA	NA	Moderate		Inter Info	[2]
D0541		Durvalumab	NA	NA	Moderate		Inter Info	[2]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[2]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[2]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[2]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[2]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[2]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[2]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[2]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[2]
D0801		Inebilizumab	NA	NA	Moderate		Inter Info	[2]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[2]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[2]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[2]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[2]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[2]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[2]
D0939		Lisocabtagene maraleucel	NA	NA	Moderate		Inter Info	[2]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[2]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[2]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[2]
D1083		Mogamulizumab	NA	NA	Moderate		Inter Info	[2]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[2]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[2]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[2]
D1161		Obinutuzumab	NA	NA	Moderate		Inter Info	[2]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[2]
D1164		Ofatumumab	NA	NA	Moderate		Inter Info	[2]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[2]
D1168		Olaratumab	NA	NA	Moderate		Inter Info	[2]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[2]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[2]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[2]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[2]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[2]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[2]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[2]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[53]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[2]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[34], [35], [36]
D1410		Risankizumab	NA	NA	Moderate		Inter Info	[2]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[2]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[2]
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Moderate		Inter Info	[2]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[2]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[2]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[2]
D1458		Selinexor	C17H11F6N7O	71481097	Moderate		Inter Info	[2]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[2]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[2]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[54]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[14], [6], [55]
D1529		Tafasitamab	NA	NA	Moderate		Inter Info	[2]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[2]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[2]
D1583		Tildrakizumab	NA	NA	Moderate		Inter Info	[2]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[2]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2]
D1622		Trastuzumab deruxtecan	NA	NA	Moderate		Inter Info	[2]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[2]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[2]
D1685		Vedolizumab	NA	NA	Moderate		Inter Info	[2]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[2]
D1176		Omalizumab	NA	NA	Moderate		Inter Info	[2]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[2]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[2]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[2]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[56]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[2]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[2]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[2]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[2]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[2]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[2]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[2]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[2]
D1416		Rituximab	NA	NA	Moderate		Inter Info	[2]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[6], [58]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[2]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[2]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[2]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[2]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[2]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[2]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[2]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[2]
D1598		Tocainide	C11H16N2O	38945	Moderate		Inter Info	[2]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[2]
D1621		Trastuzumab	NA	NA	Moderate		Inter Info	[2]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[2]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[2]
D1639		Trifluridine	C10H11F3N2O5	6256	Moderate		Inter Info	[2]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[2]
D1646		Trimetrexate	C19H23N5O3	5583	Moderate		Inter Info	[2]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Moderate		Inter Info	[2]
D1678		Valrubicin	C34H36F3NO13	454216	Moderate		Inter Info	[2]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[2]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[2]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[2]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[2]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[2]
	Additive myelosuppressive effects					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[14], [18], [19]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[23]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[2]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[2]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[2]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[2]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[2]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[14], [6], [41]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[2]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[2]
D1245		Penicillamine	C5H11NO2S	5852	Moderate		Inter Info	[2]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[2]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[14], [6], [41]
	Increased risk of bleeding					Drug Num: 81
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2]
D0047		Alteplase	NA	NA	Major		Inter Info	[1], [2]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1], [2]
D0088		Anistreplase	NA	NA	Major		Inter Info	[1], [2]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1], [2]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1], [2]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1], [2]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1], [2]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1], [2]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1], [2]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[1], [2]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1], [2]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1], [2]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[1], [2]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1], [2]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1], [2]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1], [2]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[1], [2]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[1], [2]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1], [2]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[1], [2]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1], [2]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1], [2]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1], [2]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1], [2]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1], [2]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1], [2]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1], [2]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1], [2]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1], [2]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[1], [2]
D0092		Antithrombin Alfa	NA	NA	Major		Inter Info	[1], [2]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[1], [2]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1], [2]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1], [2]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1], [2]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Major		Inter Info	[1], [2]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[16], [17]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[1], [2]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[1], [2]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2]
D0415		Danaparoid	NA	NA	Major		Inter Info	[1], [2]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[1], [2]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[1], [2]
D0462		Dextran (-1)	C18H32O16	4125253	Major		Inter Info	[1], [2]
D0463		Dextran (high molecular weight)	C18H32O16	4125253	Major		Inter Info	[1], [2]
D0464		Dextran (low molecular weight)	C18H32O16	4125253	Major		Inter Info	[1], [2]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1], [2]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1], [2]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1], [2]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[1], [2]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1], [2]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1], [2]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[1], [22]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[1], [2]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[1], [2]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[1], [2]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[1], [2]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[1], [2]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[1], [2]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1], [2]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1], [2]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1], [2]
D1395		Reteplase	NA	NA	Major		Inter Info	[1], [2]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[1], [2]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Major		Inter Info	[1], [2]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1], [2]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1], [2]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1], [2]
D1613		Tositumomab	NA	NA	Major		Inter Info	[1], [2]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[1], [2]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[1], [2]
D1669		Urokinase	NA	NA	Major		Inter Info	[1], [2]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1], [2]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[52]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 41
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[29], [30], [31]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[29], [30], [31]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[29], [30], [31]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[29], [30], [31]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[29], [30], [31]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[29], [30], [31]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[29], [30], [31]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[29], [30], [31]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[29], [30], [31]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[29], [30], [31]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[29], [30], [31]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[29], [30], [31]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[29], [30], [31]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[29], [30], [31]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[29], [30], [31]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[29], [30], [31]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[29], [30], [31]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[29], [30], [31]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[29], [30], [31]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[29], [30], [31]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[29], [30], [31]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[29], [30], [31]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[29], [30], [31]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[29], [30], [31]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[29], [30], [31]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[29], [30], [31]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[29], [30], [31]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[29], [30], [31]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[29], [30], [31]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[29], [30], [31]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[29], [30], [31]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[29], [30], [31]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[29], [30], [31]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[29], [30], [31]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[29], [30], [31]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[29], [30], [31]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[29], [30], [31]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[29], [30], [31]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[29], [30], [31]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[29], [30], [31]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[29], [30], [31]
	Antagonize the effect of antihypertensive agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[29], [30], [31]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[29], [30], [31]
	Antagonize the effect of vaccine/toxoid					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[11], [12], [13]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[11], [12], [13]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[11], [12], [13]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[25], [14], [26]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[27]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[11], [12], [13]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[11], [12], [13]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[11], [12], [13]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[42]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[25], [43], [44]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [43], [44]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[25], [43], [44]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[25], [43], [44]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[25], [43], [44]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[25], [43], [44]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [43], [44]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[25], [43], [44]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[25], [43], [44]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [43], [44]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[25], [43], [44]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[25], [43], [44]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[45], [46], [47]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[45], [46], [47]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[48], [49], [50]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[48], [49], [50]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[48], [49], [50]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[48], [49], [50]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[38], [39], [40]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[1], [57]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[38], [39], [40]

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34	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
35	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
36	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
37	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
38	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
39	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
40	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
41	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
42	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
43	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
44	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
45	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
46	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
47	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
48	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
49	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
50	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
51	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
52	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
53	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
54	AnazaoHealth Corporation "P32 Sodium Phosphate."
55	Multum Information Services, Inc. Expert Review Panel.
56	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
57	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
58	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.

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