Details of Drug

Details of Drug

 Drug General Information (ID: D1067)
  Drug Name
Milrinone
  Drug Type Small molecule
  Drug Synonymous
Corotrop; Corotrope; Milrila; Milrinona; Milrinonum; Primacor; Milrinona [Spanish]; Milrinonum [Latin]; M 4659; M1663; YM 018; MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER; Milrila (TN); PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER; Primacor (TN); WIN 47203-2; Win-47203; Milrinone [USAN:BAN:INN]; Win-47203-2; Milrinone (JAN/USAN/INN); 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile; 111GE027; 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile; 3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone; 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
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  Disease Class BD10-BD1Z: Heart failure
  Therapeutic Class Cardiotonic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C12H9N3O
  InChI 1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
  InChIKey PZRHRDRVRGEVNW-UHFFFAOYSA-N
  Canonical SMILES CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
  External Link
Pubchem ID 4197
CAS Number 78415-72-2
CHEBI ID 50693
TTD ID D0Y9ZE

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM042  Additive hypotensive effects
  Relation Graph
 Full list of drugs interacting with Milrinone
      Pharmacodynamic additive effects
   Additive hypotensive effects Drug Num:  15
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Major    Inter Info   
[1]
D0055
 
Amifostine
 
C5H15N2O3PS
 
2141 
Moderate    Inter Info   
[2], [3], [4]
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Moderate    Inter Info   
[5]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[6]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [3], [17], [18]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [3], [17], [18]
D0980
 
Maraviroc
 
C29H41F2N5O
 
3002977 
Moderate    Inter Info   
[19]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[20], [21], [22]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [3], [17], [18]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [3], [17], [18]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [3], [17], [18]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [3], [17], [18]
D1437
 
Safinamide
 
C17H19FN2O2
 
131682 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [3], [17], [18]
D1455
 
Selegiline
 
C13H17N
 
26757 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [3], [17], [18]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Moderate    Inter Info   
[13], [17], [18]
References
1 Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
2 Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
3 Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
4 Product Information. Ethyol (amifostine). Alza, Palo Alto, CA.
5 Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
6 Product Information. Inocor (inamrinone). Sanofi Winthrop Pharmaceuticals, New York, NY.
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13 Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
14 Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
15 Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
16 Product Information. Parnate (tranylcypromine). SmithKline Beecham, Philadelphia, PA.
17 Reggev A, Vollhardt BR "Bradycardia induced by an interaction between phenelzine and beta blockers." Psychosomatics 30 (1992): 106-8. [PMID: 2913594]
18 Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
19 Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
20 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
21 Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
22 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]