Details of Drug

Drug General Information (ID: D1036)
Drug Name	Methylene blue
Drug Type	Small molecule
Drug Synonymous	methylene blue; 61-73-4; Methylthioninium chloride; Swiss Blue; Chromosmon; Methylene Blue N; Methylenium ceruleum; Urolene blue; Methylene Blue chloride; Solvent blue 8; Bleu de methylene; Methylene Blue G; Methylene Blue A; External Blue 1; Methylene Blue D; Methylene Blue B; Methylene Blue anhydrous; CI Basic Blue 9; Methylene Blue ZF; Methylene Blue SP; Methylene Blue NZ; Methylene Blue BX; Methylene Blue BD; Methylene Blue SG; Tetramethylene Blue; Methylene Blue ZX; Methylene Blue FZ; Methylene Blue BP; Calcozine; 3,7-Bis-dimethylamino-phenothiazin-5-ylium Click to Show/Hide
Disease Class	3A93: Acquired methaemoglobinaemia
Therapeutic Class	Antidotes/Mao Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C16H18ClN3S
InChI	1S/C16H18N3S.ClH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;/h5-10H,1-4H3;1H/q+1;/p-1
InChIKey	CXKWCBBOMKCUKX-UHFFFAOYSA-M
Canonical SMILES	CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]
External Link
	Pubchem ID	6099
	CAS Number	61-73-4
	CHEBI ID	6872
	TTD ID	D09NYS

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM018 Non-CYP450 enzyme inhibition BM033 Additive anticholinergic effects BM038 Additive CNS depression effects BM040 Additive dopaminergic effects BM041 Additive hypertensive effects BM046 Additive serotonergic effects BM061 Increased risk of hyperpyrexia BM078 Increased risk of rapid heart rate BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Methylene blue
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[154]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1035		Methyldopa	C10H13NO4	38853	Major		Inter Info	[26], [5], [163], [11], [164], [39], [165], [166]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[171]
D1419		Rizatriptan	C15H19N5	5078	Major		Inter Info	[4], [5], [87], [6], [7], [8], [9], [10], [11], [175], [176], [177], [12]
D1521		Sumatriptan	C14H21N3O2S	5358	Major		Inter Info	[4], [5], [87], [6], [7], [8], [9], [10], [11], [175], [176], [177], [12]
D1728		Zolmitriptan	C16H21N3O2	60857	Major		Inter Info	[4], [5], [87], [6], [7], [8], [9], [10], [11], [175], [176], [177], [12]
D0505		Dipivefrin (ophthalmic)	C19H29NO5	3105	Moderate		Inter Info	[198], [26], [199]
D0580		Ephedrine (nasal)	C10H15NO	9294	Moderate		Inter Info	[198], [26], [199]
D0582		Epinephrine (ophthalmic)	C9H13NO3	5816	Moderate		Inter Info	[198], [26], [199]
D0583		Epinephrine (topical)	C9H13NO3	5816	Moderate		Inter Info	[198], [26], [199]
D0913		Levmetamfetamine (nasal)	C10H15N	36604	Moderate		Inter Info	[198], [26], [199]
D1107		Naphazoline (nasal)	C14H14N2	4436	Moderate		Inter Info	[198], [26], [199]
D1108		Naphazoline (ophthalmic)	C14H14N2	4436	Moderate		Inter Info	[198], [26], [199]
D1204		Oxymetazoline (nasal)	C16H24N2O	4636	Moderate		Inter Info	[198], [26], [199]
D1205		Oxymetazoline (ophthalmic)	C16H24N2O	4636	Moderate		Inter Info	[198], [26], [199]
D1206		Oxymetazoline (topical)	C16H24N2O	4636	Moderate		Inter Info	[198], [26], [199]
D1277		Phenylephrine (nasal)	C9H13NO2	6041	Moderate		Inter Info	[198], [26], [199]
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[198], [26], [199]
D1280		Phenylephrine (topical)	C9H13NO2	6041	Moderate		Inter Info	[198], [26], [199]
D1358		Propylhexedrine (nasal)	C10H21N	7558	Moderate		Inter Info	[198], [26], [199]
D1568		Tetryzoline (ophthalmic)	C13H16N2	5419	Moderate		Inter Info	[198], [26], [199]
D1712		Xylometazoline (nasal)	C16H24N2	5709	Moderate		Inter Info	[198], [26], [199]
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0532		Doxylamine	C17H22N2O	3162	Major		Inter Info	[14], [126], [127], [128]
	Additive CNS depression effects					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1], [2], [3]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[1], [2], [3]
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[1], [2], [3]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[1], [2], [3]
D0471		Diamorphine	C21H23NO5	5462328	Major		Inter Info	[1], [2], [3]
D0493		Dihydrocodeine	C18H23NO3	5284543	Major		Inter Info	[1], [2], [3]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[1], [2], [3]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[1], [2], [3]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[1], [2], [3]
D0923		Levorphanol	C17H23NO	5359272	Major		Inter Info	[1], [2], [3]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[1], [2], [3]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1], [2], [3]
D1183		Opium	NA	NA	Major		Inter Info	[1], [2], [3]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[1], [2], [3]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[1], [2], [3]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[1], [2], [3]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[1], [2], [3]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[1], [2], [3]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1], [2], [3]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1], [2], [3]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1], [2], [3]
	Additive dopaminergic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1492		Solriamfetol	C10H14N2O2	10130337	Major		Inter Info	[172]
	Additive hypertensive effects					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0098		Apraclonidine	C9H10Cl2N4	2216	Major		Inter Info	[5], [43], [39]
D0575		Entacapone	C14H15N3O5	5281081	Major		Inter Info	[129], [11], [130]
D0918		Levodopa	C9H11NO4	6047	Major		Inter Info	[23], [24], [26], [5], [28], [155], [11], [156], [157], [158], [38], [159], [160], [40], [161], [42]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[167], [168], [169]
D0600		Esketamine	C13H16ClNO	182137	Major		Inter Info	[132], [170]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Major		Inter Info	[129], [11], [130]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[167], [168], [169]
D1567		Tetryzoline (nasal)	C13H16N2	5419	Major		Inter Info	[65], [178], [174]
D1604		Tolcapone	C14H11NO5	4659569	Major		Inter Info	[129], [11], [130]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[179], [118], [26], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[195], [196], [39]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[195], [196], [39]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[5], [28], [11], [39], [197]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[23], [24], [198], [26], [5], [27], [28], [121], [11], [39], [160], [200], [199], [42]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[201]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[23], [24], [198], [26], [5], [27], [28], [121], [11], [39], [160], [200], [199], [42]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[179], [118], [26], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[179], [118], [26], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[179], [118], [26], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[118], [185], [194]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[132], [14], [205]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[28], [39], [160]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[23], [24], [198], [26], [5], [27], [28], [121], [11], [39], [160], [200], [199], [42]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[118], [185], [194]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[179], [118], [26], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[23], [24], [198], [26], [5], [27], [28], [121], [11], [39], [160], [200], [199], [42]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[23], [24], [198], [26], [5], [27], [28], [121], [11], [39], [160], [200], [199], [42]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[179], [118], [26], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[118], [185], [194]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[179], [118], [26], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[5], [28], [11], [39], [197]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[179], [118], [26], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[118], [185], [194]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[179], [118], [26], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[179], [118], [26], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[118], [185], [194]
	Additive serotonergic effects					Drug Num: 61
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0041		Almotriptan	C17H25N3O2S	123606	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[13], [4], [44], [45], [5], [46], [47], [28], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [8], [9], [10], [58], [59], [11], [60], [61], [1], [62], [63], [64], [65], [66], [67], [68], [39], [69], [12], [70], [71], [72], [73], [42], [74], [75]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0398		Cyclobenzaprine	C20H21N	2895	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0457		Dexfenfluramine	C12H16F3N	66265	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0466		Dextromethorphan	C18H25NO	5360696	Major		Inter Info	[78], [79], [80], [81], [82], [83], [84], [85], [4], [86], [26], [5], [87], [88], [89], [47], [7], [90], [91], [92], [48], [93], [94], [95], [96], [97], [8], [98], [99], [9], [10], [11], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [39], [111], [69], [112], [113], [12], [114], [115], [116], [72], [73]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[117], [60], [3]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[69], [12], [70]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[78], [79], [80], [81], [82], [83], [84], [85], [4], [86], [26], [5], [87], [88], [89], [47], [7], [90], [91], [92], [48], [93], [94], [95], [96], [97], [8], [98], [99], [9], [10], [11], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [39], [111], [69], [112], [113], [12], [114], [115], [116], [72], [73]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[131], [132], [14], [4], [133], [5], [134], [135], [90], [117], [28], [49], [136], [8], [137], [9], [10], [138], [11], [139], [60], [140], [141], [61], [63], [64], [65], [142], [66], [67], [68], [39], [143], [12], [144], [145], [146], [147], [148], [3]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0702		Frovatriptan	C14H17N3O	77992	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[149], [132], [14], [150], [151], [152], [153]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0952		Lorcaserin	C11H14ClN	11658860	Major		Inter Info	[162]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[131], [132], [14], [4], [133], [5], [134], [135], [90], [117], [28], [49], [136], [8], [137], [9], [10], [138], [11], [139], [60], [140], [141], [61], [63], [64], [65], [142], [66], [67], [68], [39], [143], [12], [144], [145], [146], [147], [148], [3]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[131], [132], [14], [4], [133], [5], [134], [135], [90], [117], [28], [49], [136], [8], [137], [9], [10], [138], [11], [139], [60], [140], [141], [61], [63], [64], [65], [142], [66], [67], [68], [39], [143], [12], [144], [145], [146], [147], [148], [3]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[173], [65], [174]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1110		Naratriptan	C17H25N3O2S	4440	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[149], [132], [14], [150], [151], [152], [153]
D1198		Oxcarbazepine	C15H12N2O2	34312	Major		Inter Info	[13], [4], [44], [45], [5], [46], [47], [28], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [8], [9], [10], [58], [59], [11], [60], [61], [1], [62], [63], [64], [65], [66], [67], [68], [39], [69], [12], [70], [71], [72], [73], [42], [74], [75]
D1200		Oxitriptan	C11H12N2O3	439280	Major		Inter Info	[91], [96], [97]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[149], [132], [14], [150], [151], [152], [153]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1437		Safinamide	C17H19FN2O2	131682	Major		Inter Info	[60], [61], [1]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1658		Tryptophan	C11H12N2O2	6305	Major		Inter Info	[78], [79], [80], [81], [82], [83], [84], [85], [4], [86], [26], [5], [87], [88], [89], [47], [7], [90], [91], [92], [48], [93], [94], [95], [96], [97], [8], [98], [99], [9], [10], [11], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [39], [111], [69], [112], [113], [12], [114], [115], [116], [72], [73]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
	Increased risk of hyperpyrexia					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0074		Amphetamine	C9H13N	3007	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0165		Benzphetamine	C17H21N	5311017	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[76], [67], [77]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[76], [67], [77]
D0460		Dexmethylphenidate	C14H19NO2	154101	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0465		Dextroamphetamine	C9H13N	5826	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0486		Diethylpropion	C13H19NO	7029	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0517		Dopamine	C8H11NO2	681	Major		Inter Info	[23], [118], [119], [26], [120], [5], [27], [28], [121], [29], [122], [123], [124], [56], [125], [11], [38], [39], [40], [41], [42]
D0523		Doxapram	C24H30N2O2	3156	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0579		Ephedrine	C10H15NO	9294	Major		Inter Info	[23], [118], [119], [26], [120], [5], [27], [28], [121], [29], [122], [123], [124], [56], [125], [11], [38], [39], [40], [41], [42]
D0857		Isometheptene	C9H19N	22297	Major		Inter Info	[120], [121], [29]
D0981		Mazindol	C16H13ClN2O	4020	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1002		Mephentermine	C11H17N	3677	Major		Inter Info	[23], [118], [119], [26], [120], [5], [27], [28], [121], [29], [122], [123], [124], [56], [125], [11], [38], [39], [40], [41], [42]
D1012		Metamfetamine	C10H15N	10836	Major		Inter Info	[24], [31], [32]
D1013		Metaraminol	C9H13NO2	5906	Major		Inter Info	[23], [118], [119], [26], [120], [5], [27], [28], [121], [29], [122], [123], [124], [56], [125], [11], [38], [39], [40], [41], [42]
D1039		Methylphenidate	C14H19NO2	4158	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1262		Phendimetrazine	C12H17NO	30487	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1270		Phentermine	C10H15N	4771	Major		Inter Info	[23], [24], [25], [26], [5], [27], [28], [29], [30], [31], [11], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1276		Phenylephrine	C9H13NO2	6041	Major		Inter Info	[23], [118], [119], [26], [120], [5], [27], [28], [121], [29], [122], [123], [124], [56], [125], [11], [38], [39], [40], [41], [42]
D1281		Phenylpropanolamine	C9H13NO	26934	Major		Inter Info	[23], [118], [119], [26], [120], [5], [27], [28], [121], [29], [122], [123], [124], [56], [125], [11], [38], [39], [40], [41], [42]
D1363		Pseudoephedrine	C10H15NO	7028	Major		Inter Info	[23], [118], [119], [26], [120], [5], [27], [28], [121], [29], [122], [123], [124], [56], [125], [11], [38], [39], [40], [41], [42]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[206], [207]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[26], [5], [202], [203], [204], [11], [67], [39]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[26], [5], [202], [203], [204], [11], [67], [39]

References
1	Product Information. Emsam (selegiline). Bristol-Myers Squibb, Princeton, NJ.
2	Product Information. Tylenol with Codeine (acetaminophen-codeine). Janssen Pharmaceuticals, Raritan, NJ.
3	Zornberg GL, Hegarty JD "Adverse interaction between propoxyphene and phenelzine." Am J Psychiatry 150 (1993): 1270-1. [PMID: 8328578]
4	Chan BSH, Graudins A, Whyte IM, Dawson AH, Braitberg G, Duggin GG "Serotonin syndrome resulting from drug interactions." Med J Aust 169 (1998): 523-5. [PMID: 9861909]
5	De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5. [PMID: 4379192]
6	Fleishaker JC, Ryan KK, Jansat JM, et al. "Effect of MAO-A inhibition on the pharmacokinetics of almotriptan, an antimigraine agent in humans." Br J Clin Pharmacol 51 (2001): 437-41. [PMID: 11422001]
7	Gardner DM, Lynd LD "Sumatriptan contraindications and the serotonin syndrome." Ann Pharmacother 32 (1998): 33-8. [PMID: 9475817]
8	Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6. [PMID: 8909274]
9	Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763. [PMID: 9330840]
10	Nierenberg DW, Semprebon M "The central nervous system serotonin syndrome." Clin Pharmacol Ther 53 (1993): 84-8. [PMID: 8257462]
11	Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7. [PMID: 5655478]
12	Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13. [PMID: 2035713]
13	Boyer EW, Shannon M "The serotonin syndrome." N Engl J Med 352 (2005): 1112-20. [PMID: 15784664]
14	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
15	Gillman PK "Methylene blue and serotonin toxicity: definite causal link." Psychosomatics 51 (2010): 448-9. [PMID: 20833947]
16	Gillman PK "Methylene blue is a potent monoamine oxidase inhibitor." Can J Anaesth 55 (2008): 311-2 author reply 312. [PMID: 18451123]
17	Heritier Barras AC, Walder B, Seeck M "Serotonin syndrome following Methylene Blue infusion: a rare complication of antidepressant therapy." J Neurol Neurosurg Psychiatry 81 (2010): 1412-3. [PMID: 20547626]
18	Khavandi A, Whitaker J, Gonna H "Serotonin toxicity precipitated by concomitant use of citalopram and methylene blue." Med J Aust 189 (2008): 534-5. [PMID: 18976207]
19	Ng BK, Cameron AJ "The role of methylene blue in serotonin syndrome: a systematic review." Psychosomatics 51 (2010): 194-200. [PMID: 20484716]
20	Ng BK, Cameron AJ, Liang R, Rahman H. Serotonin syndrome following methylene blue infusion during parathyroidectomy: a case report and literature review.?Can J Anaesth. 2008;55(1):36-41. [PMID: 18166746]
21	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Serious CNS reactions possible when linezolid (Ayvox) is given to patients taking certain psychiatric medications.".
22	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Serious CNS reactions possible when methylene blue is given to patients taking certain psychiatric medications.".
23	Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
24	Boakes AJ, Laurence DR, Teoh PC, Barar FS, Benedikter LT, Pritchard BN "Interactions between sympathomimetic amines and antidepressant agents in man." Br Med J 1 (1973): 311-5. [PMID: 4685619]
25	FISCHER E, ORLANDO J, LUDMER RL. INFLUENCIA DE METILANFETAMINA, IPRONIACIDA Y TRANILCIPROMINA SOBRE LA DEPRESI'ON PSICOMOTORA ADRENAL'INICA [EFFECT OF METHYLAMPHETAMINE, IPRONIAZID AND TRANYLCYPROMINE ON ADRENALINE PSYCHOMOTOR DEPRESSION]. Prensa Med Argent. 1964;51:1538-1540. [PMID: 14272082]
26	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
27	Elis J, Laurence DR, Mattie H, Prichard BN "Modification by monoamine oxidase inhibitors of the effect of some sympathomimetics on blood pressure." Br Med J 2 (1967): 75-8. [PMID: 6020852]
28	Goldberg LI "Monoamine oxidase inhibitors: adverse reactions and possible mechanisms." JAMA 190 (1964): 456-62. [PMID: 14197995]
29	Harrison WM, McGrath PJ, Stewart JW, Quitkin F "MAOIs and hypertensive crises: the role of OTC drugs." J Clin Psychiatry 50 (1989): 64-5. [PMID: 2464583]
30	Krisko I, Lewis E, Johnson JE "Severe hyperpyrexia due to tranylcypromine-amphetamine toxicity." Ann Intern Med 70 (1969): 559-64. [PMID: 5775035]
31	Markowitz JS, Patrick KS "Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder." Clin Pharmacokinet 40 (2001): 753-72. [PMID: 11707061]
32	Product Information. Adderall (amphetamine-dextroamphetamine) Shire Richwood Pharmaceutical Company, Florence, KY.
33	Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.
34	Product Information. Focalin (dexmethylphenidate). Mikart Inc, Atlanta, GA.
35	Product Information. Ritalin (methylphenidate). Novartis Pharmaceuticals, East Hanover, NJ.
36	Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
37	Product Information. Vyvanse (lisdexamfetamine). Shire US Inc, Florence, KY.
38	Schildkraut JJ, Klerman GL, Friend DG, Greenblatt M "Biochemical and pressor effects of oral d,l-dihydroxyphenylalanine in patients pretreated with antidepressant drugs." Ann N Y Acad Sci 107 (1963): 1005-15. [PMID: 13991689]
39	Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
40	Sjoqvist F "Psychotropic drugs (2) interaction between monoamine oxidase (MAO) inhibitors and other substances." Proc R Soc Med 58 (1965): 967-78. [PMID: 4952963]
41	Smookler S, Bermudez AJ "Hypertensive crisis resulting from an MAO inhibitor and an over-the-counter appetite suppressant." Ann Intern Med 11 (1982): 482-4. [PMID: 7114595]
42	Wright SP "Hazards with monoamine-oxidase inhibitors: a persistent problem." Lancet 1 (1978): 284-5. [PMID: 74715]
43	Product Information. Iopidine (apraclonidine). Alcon Laboratories Inc, Fort Worth, TX.
44	Dardennes RM, Even C, Ballon N, Bange F "Serotonin syndrome caused by a clomipramine-moclobemide interaction." J Clin Psychiatry 59 (1998): 382-3. [PMID: 9714270]
45	de la Fuente JR, Berlanga C, Leon-Andrade C "Mania induced by tricyclic-MAOI combination therapy in bipolar treatment-resistant disorder: case reports." J Clin Psychiatry 47 (1986): 40-1. [PMID: 3941059]
46	Feighner JP, Herbstein J, Damlouji N "Combined MAOI, TCA, and direct stimulant therapy of treatment- resistant depression." J Clin Psychiatry 46 (1985): 206-9. [PMID: 3997787]
47	Fischer P "Serotonin syndrome in the elderly after antidepressive monotherapy." J Clin Psychopharmacol 15 (1995): 440-2. [PMID: 8748434]
48	Graham PM, Potter JM, Paterson J "Combination monoamine oxidase inhibitor/tricyclic antidepressants interaction." Lancet 2 (1982): 440. [PMID: 6124828]
49	Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):.
50	Joffe RT, Post RM, Uhde TW "Lack of pharmacokinetic interaction of carbamazepine with tranylcypromine." Arch Gen Psychiatry 42 (1985): 738. [PMID: 4015316]
51	Kay DW, Garside RF, Fahy TJ "A double-blind trial of phenelzine and amitriptyline in depressed out- patients. A possible differential effect of the drugs on symptoms." Br J Psychiatry 123 (1973): 63-7. [PMID: 4580991]
52	Keegan MT, Brown DR, Rabinstein AA "Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs." Anesth Analg 103 (2006): 1466-8. [PMID: 17122225]
53	Ketter TA, Post RM, Parekh PI, Worthington K "Addition of monoamine oxidase inhibitors to carbamazepine: preliminary evidence of safety and antidepressant efficacy in treatment-resistant depression." J Clin Psychiatry 56 (1995): 471-5. [PMID: 7559374]
54	Kline SS, Mauro LS, Scala-Bennett DM, Zick D "Serotonin syndrome versus neuroleptic malignant death syndrome as a cause of death." Clin Pharm 8 (1989): 510-4. [PMID: 2568897]
55	Lader M "Combined use of tricyclic antidepressants and monoamine oxidase inhibitors." J Clin Psychiatry 44 (1983): 20-4. [PMID: 6355073]
56	Lefebvre H, Noblet C, Morre N, Wolf LM "Pseudo-phaeochromocytoma after multiple drug interactions involving the selective monoamine oxidase inhibitor selegiline." Clin Endocrinol (Oxf) 42 (1995): 95-8. [PMID: 7889639]
57	Lydiard RB, White D, Harvey B, Taylor A "Lack of pharmacokinetic interaction between tranylcypromine and carbamazepine." J Clin Psychopharmacol 7 (1987): 360. [PMID: 3680612]
58	Otte W, Birkenhager TK, van den Broek WW "Fatal interaction between tranylcypromine and imipramine." Eur Psychiatry 18 (2003): 264-5. [PMID: 12927331]
59	Pascual J, Combarros O, Berciano J "Partial status epilepticus following single low dose of chlorimipramine in a patient on MAO-inhibitor treatment." Clin Neuropharmacol 10 (1987): 565-7. [PMID: 3427564]
60	Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
61	Product Information. Eldepryl (selegiline). Somerset Pharmaceuticals Inc, Tampa, FL.
62	Product Information. Flexeril (cyclobenzaprine). Merck & Co, Inc, West Point, PA.
63	Product Information. Furoxone (furazolidone). Roberts Pharmaceutical Corporation, Eatontown, NJ.
64	Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
65	Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
66	Product Information. Methylene Blue (methylene blue). American Regent Laboratories Inc, Shirley, NY.
67	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
68	Product Information. Parnate (tranylcypromine). SmithKline Beecham, Philadelphia, PA.
69	Spiker DG, Pugh DD "Combining tricyclic and monoamine oxidase inhibitor antidepressants." Arch Gen Psychiatry 33 (1976): 828-30. [PMID: 942286]
70	Tackley RM, Tregaskis B "Fatal disseminated intravascular coagulation following a monoamine oxidase inhibitor/tricyclic interaction." Anaesthesia 42 (1987): 760-3. [PMID: 3631476]
71	Waghray SN, Francis K "Epilepsy as an adverse reaction to combined therapy of MAOIs and tricyclics." J R Soc Med 77 (1984): 346. [PMID: 6425500]
72	White K, Pistole T, Boyd JL "Combined monoamine oxidase inhibitor-tricyclic antidepressant treatment: a pilot study." Am J Psychiatry 137 (1980): 1422-5. [PMID: 7435677]
73	White K, Simpson G "Combined MAOI-tricyclic antidepressant treatment: a reevaluation." J Clin Psychopharmacol 1 (1981): 264-82. [PMID: 7037873]
74	Yatham LN, Barry S, Mobayed M, Dinan TG "Is the carbamazepine-phenelzine combination safe?." Am J Psychiatry 147 (1990): 367. [PMID: 2309956]
75	Zetin M "Combined use of trimipramine and phenelzine in depression." J Nerv Ment Dis 170 (1982): 246-7. [PMID: 7062012]
76	Product Information. Cocaine Hydrochloride Nasal (cocaine nasal). Genus Lifesciences Inc., Allentown, PA.
77	Tordoff SG, Stubbing JF, Linter SP "Delayed excitatory reaction following interaction of cocaine and monoamine oxidase inhibitor (phenelzine)." Br J Anaesth 66 (1991): 516-8. [PMID: 2025483]
78	Alvine G, Black DW, Tsuang D "Case of delirium secondary to phenelzine/L-tryptophan combination." J Clin Psychiatry 51 (1990): 311. [PMID: 2365671]
79	Beasley CM Jr, Masica DN, Heiligenstein JH, Wheadon DE, Zerbe RL "Possible monoamine oxidase inhibitor-serotonin uptake inhibitor interaction: fluoxetine clinical data and preclinical findings." J Clin Psychopharmacol 13 (1993): 312-20. [PMID: 8227489]
80	Bem JL, Peck R "Dextromethorphan. An overview of safety issues." Drug Saf 7 (1992): 190-9. [PMID: 1503667]
81	Bhatara VS, Bandettini FC "Possible interaction between sertraline and tranylcypromine." Clin Pharm 12 (1993): 222-5. [PMID: 8491079]
82	Bodner RA, Lynch T, Lewis L, Kahn D "Serotonin syndrome." Neurology 45 (1995): 219-23. [PMID: 7854515]
83	Brannan SK, Talley BJ, Bowden CL "Sertraline and isocarboxazid cause a serotonin syndrome." J Clin Psychopharmacol 14 (1994): 144-5. [PMID: 8195456]
84	Brubacher JR, Hoffman RS, Lurin MJ "Serotonin syndrome from venlafaxine-tranylcypromine interaction." Vet Hum Toxicol 38 (1996): 358-61. [PMID: 8888541]
85	Cetaruk EW, Aaron CK "Hazards of nonprescription medications." Emerg Med Clin North Am 12 (1994): 483-510. [PMID: 8187693]
86	Corkeron MA "Serotonin syndrome - a potentially fatal complication of antidepressant therapy." Med J Aust 163 (1995): 481-2. [PMID: 7476638]
87	Diamond S "The use of sumatriptan in patients on monoamine oxidase inhibitors." Neurology 45 (1995): 1039-40. [PMID: 7783861]
88	Diamond S, Pepper BJ, Diamond ML, Freitag FG, Urban GJ, Erdemoglu AK "Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports." Neurology 51 (1998): 274-6. [PMID: 9674820]
89	Feighner JP, Boyer WF, Tyler DL, Neborsky RJ "Adverse consequences of fluoxetine-MAOI combination therapy." J Clin Psychiatry 51 (1990): 222-5. [PMID: 2347858]
90	Gillman PK "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity." Br J Anaesth (2005):. [PMID: 16051647]
91	Graber MA, Hoehns TB, Perry PJ "Sertraline-phenelzine drug interaction: a serotonin syndrome reaction." Ann Pharmacother 28 (1994): 732-5. [PMID: 7919561]
92	Graham PM, Ilett KF "Danger of MAOI therapy after fluoxetine withdrawal." Lancet 2 (1988): 1255-6. [PMID: 2903989]
93	Heisler MA, Guidry JR, Arnecke B "Serotonin syndrome induced by administration of venlafaxine and phenelzine." Ann Pharmacother 30 (1996): 84. [PMID: 8773172]
94	Jacob JE, Wagner ML, Sage JI "Safety of selegiline with cold medications." Ann Pharmacother 37 (2003): 438-41. [PMID: 12639177]
95	Jimenez-Genchi A "Immediate switching from moclobemide to duloxetine may induce serotonin syndrome." J Clin Psychiatry 67 (2006): 1821-1822. [PMID: 17196070]
96	Klysner R, Larsen JK, Sorensen P, Hyllested M, Pedersen BD "Toxic interaction of venlafaxine and isocarboxazide." Lancet 346 (1995): 1298-9. [PMID: 7475741]
97	Levy AB, Bucher P, Votolato N "Myoclonus, hyperreflexia and diaphoresis in patients on phenelzine- tryptophan combination treatment." Can J Psychiatry 30 (1985): 434-6. [PMID: 4063940]
98	Mathew NT, Tietjen GE, Lucker C "Serotonin syndrome complicating migraine pharmacotherapy." Cephalalgia 16 (1996): 323-7. [PMID: 8869767]
99	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
100	Phillips SD, Ringo P "Phenelzine and venlafaxine interaction." Am J Psychiatry 152 (1995): 1400-1. [PMID: 7653704]
101	Pope HG Jr, Jonas JM, Hudson JI, Kafka MP "Toxic reactions to the combination of monoamine oxidase inhibitors and tryptophan." Am J Psychiatry 142 (1985): 491-2. [PMID: 3976924]
102	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
103	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
104	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
105	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
106	Product Information. Manerix (moclobemide). Hoffmann-La Roche Limited, Mississauga, IA.
107	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
108	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
109	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
110	Rivers N, Horner B "Possible lethal reaction between nardil and dextromethorphan." Can Med Assoc J 103 (1970): 85. [PMID: 20311659]
111	Sovner R, Wolfe J "Interaction between dextromethorphan and monoamine oxidase inhibitor therapy with isocarboxazid ." N Engl J Med 319 (1988): 1671. [PMID: 3200285]
112	Staufenberg EF, Tantam D "Malignant hyperpyrexia syndrome in combined treatment." Br J Psychiatry 154 (1989): 577-8. [PMID: 2590798]
113	Sternbach H "Danger of MAOI therapy after fluoxetine withdrawal." Lancet 2 (1988): 850-1. [PMID: 2902292]
114	Suchowersky O, deVries JD "Interaction of fluoxetine and selegiline." Can J Psychiatry 35 (1990): 571-2. [PMID: 2119876]
115	Thomas JM, Rubin EH "Case report of a toxic reaction from a combination of tryptophan and phenelzine." Am J Psychiatry 141 (1984): 281-3. [PMID: 6691495]
116	Weiner LA, Smythe M, Cisek J "Serotonin syndrome secondary to phenelzine-venlafaxine interaction." Pharmacotherapy 18 (1998): 399-403. [PMID: 9545162]
117	Gillman PK "Possible serotonin syndrome with moclobemide and pethidine." Med J Aust 162 (1995): 554. [PMID: 7776924]
118	Boakes AJ, Laurence DR, Teoh PC, Barar FS, Benedikter LT, Prichard BN "Interactions between sympathomimetic amines and antidepressant agents in man." Br Med J 1 (1973): 311-5. [PMID: 4685619]
119	Cuthbert MF, Greenberg MP, Morley SW "Cough and cold remedies: a potential danger to patients on monoamine oxidase inhibitors." Br Med J 1 (1969): 404-6. [PMID: 5763957]
120	Davies B, Bannister R, Sever P "Pressor amines and monoamine-oxidase inhibitors for treatment of postural hypotension in autonomic failure: limitations and hazards." Lancet 1 (1978): 172-5. [PMID: 74603]
121	Goulet JP, Perusse R, Turcotte JY "Contraindications to vasoconstrictors in dentistry: Part III. Pharmacologic interactions." Oral Surg Oral Med Oral Pathol 74 (1992): 692-7. [PMID: 1359489]
122	Horler AR, Wynne NA "Hypertensive crisis due to pargyline and metaraminol." Br Med J 5459 (1965): 460-1. [PMID: 14314914]
123	Humberstone PM "Hypertension from cold remedies." Br Med J 1 (1969): 846. [PMID: 5813090]
124	Kraft KE, Dore FH "Computerized drug interaction programs: how reliable?." JAMA 275 (1996): 1087. [PMID: 8601924]
125	Mason AM, Buckle RM ""Cold" cures and monoamine-oxidase inhibitors." Br Med J 1 (1969): 845-6. [PMID: 5813089]
126	Product Information. Diclectin (doxylamine-pyridoxine). Duchesnay Inc, Laval, IN.
127	Product Information. Diclegis (doxylamine-pyridoxine). Duchesnay USA Inc, Rosemont, PA.
128	Skop BP, Finkelstein JA, Mareth TR, Magoon MR, Brown TM "The serotonin syndrome associated wtih paroxetine, an over-the-counter cold remedy, and vascular disease." Am J Emerg Med 12 (1994): 642-4. [PMID: 7945606]
129	Lavery S, Ravi H, McDaniel WW, Pushkin YR "Linezolid and serotonin syndrome." Psychosomatics 42 (2001): 432-4. [PMID: 11739912]
130	Product Information. Tasmar (tolcapone). Valeant Pharmaceuticals, Costa Mesa, CA.
131	Browne B, Linter S "Monoamine oxidase inhibitors and narcotic analgesics: a critical review of the implications for treatment." Br J Psychiatry 151 (1987): 210-2. [PMID: 2891392]
132	Cerner Multum, Inc. "Australian Product Information.".
133	Das PK, Warkentin DI, Hewko R, Forrest DL "Serotonin syndrome after concomitant treatment with linezolid and meperidine." Clin Infect Dis 46 (2008): 264-5. [PMID: 18171260]
134	Evans-Prosser CD "The use of pethidine and morphine in the presence of monoamine oxidase inhibitors." Br J Anaesth 40 (1968): 279-82. [PMID: 5654977]
135	Garbutt JC "Potentiation of propoxyphene by phenelzine." Am J Psychiatry 144 (1987): 251-2. [PMID: 2949636]
136	Insler SR, Kraenzler EJ, Licina MG, Savage RM, Starr NJ "Cardiac surgery in a patient taking monoamine oxidase inhibitors - an adverse fentanyl reaction." Anesth Analg 78 (1994): 593-7. [PMID: 8109782]
137	Michaels I, Serrins M, Shier NQ, Barash PG "Anesthesia for cardiac surgery in patients receiving monoamine oxidase inhibitors." Anesth Analg 63 (1984): 1041-4. [PMID: 6333833]
138	Noble WH, Baker A "MAO inhibitors and coronary artery surgery: a patient death." Can J Anaesth 39 (1992): 1061-6. [PMID: 1464133]
139	Product Information. Actiq (fentanyl). Abbott Pharmaceutical, Abbott Park, IL.
140	Product Information. Demerol (meperidine). Sanofi Winthrop Pharmaceuticals, New York, NY.
141	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
142	Product Information. Meperidine Hydrochloride Injection, USP (meperidine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
143	Starr C "Interaction between pethidine and selegiline." Lancet 337 (1991): 554. [PMID: 1671914]
144	Upton R, Graff A, Williamson E, et al. "American Herbal Pharmacopoeia and Therapeutic Compendium. Monograph printed in Herbalgram." Herbalgram 40 (1997): 1-38(monograph).
145	Vigran IM "Dangerous potentiation of meperidine hydrochloride by pargyline hydrochloride." JAMA 187 (1964): 953-4. [PMID: 14100156]
146	Weiner AL "Meperidine as a potential cause of serotonin syndrome in the emergency department." Acad Emerg Med 6 (1999): 156-8. [PMID: 10051909]
147	Youssef MS, Wilkinson PA "Epidural fentanyl and monoamine oxidase inhibitors." Anaesthesia 43 (1988): 210-2. [PMID: 3364639]
148	Zornberg GL, Bodkin JA, Cohen BM "Severe adverse interaction between pethidine and selegiline." Lancet 337 (1991): 246. [PMID: 1670882]
149	Canadian Pharmacists Association.
150	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
151	Product Information. Aloxi (palonosetron). MGI Pharma Inc, Minnetonka, MN.
152	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
153	Product Information. Sancuso (granisetron). ProStrakan Group, Bedminster, NJ.
154	Product Information. Azedra (iobenguane I-131). Progenics Pharmaceuticals, Inc., New York, NY.
155	Hunter KR, Boakes AJ, Laurence DR, Stern GM "Monoamine oxidase inhibitors and L-dopa." Br Med J 3 (1970): 388. [PMID: 5451592]
156	Product Information. Parcopa (carbidopa-levodopa). Schwarz Pharma, Mequon, WI.
157	Product Information. Sinemet (carbidopa-levodopa). DuPont Pharmaceuticals, Wilmington, DE.
158	Product Information. Stalevo 50 (carbidopa/entacapone/levodopa). Novartis Pharmaceuticals, East Hanover, NJ.
159	Sharpe J, Marquez-Julio A, Ashby P "Idiopathic orthostatic hypotension treated with levodopa and MAO inhibitor: a preliminary report." Can Med Assoc J 107 (1972): 296-300. [PMID: 5056115]
160	Sjoerdsma A "Catecholamine-drug interactions in man." Pharmacol Rev 18 (1966): 673-83. [PMID: 5904180]
161	Teychenne PF, Calne DB, Lewis PJ, Findley LJ "Interactions of levodopa with inhibitors of monoamine oxidase and L-aromatic amino acid decarboxylase." Clin Pharmacol Ther 18 (1975): 273-7. [PMID: 1164817]
162	Product Information. Belviq (lorcaserin). Eisai Inc, Teaneck, NJ.
163	Paykel ES "Hallucinosis on combined methyldopa and pargyline." Br Med J 1 (1966): 803. [PMID: 5910115]
164	Product Information. Aldomet (methyldopa). Merck & Co, Inc, West Point, PA.
165	van Rossum JM "Potential danger of monoamineoxidase inhibitors and a-methyldopa." Lancet 1 (1963): 950-1. [PMID: 13975251]
166	van Rossum JM, Hurkmans JA "Reversal of the effect of a-Methyldopa by monamine oxidase inhibitors." J Pharm Pharmacol 15 (1963): 493-9. [PMID: 14059015]
167	Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
168	Product Information. Nitoman (tetrabenazine). Cambridge Laboratories Ltd, Wallsend, Tyne & Wear, .
169	Product Information. Xenazine (tetrabenazine). Prestwick Pharmaceuticals Inc, Washington DC, VA.
170	Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
171	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
172	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.
173	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
174	Product Information. Zyvox (linezolid) Pharmacia and Upjohn, Kalamazoo, MI.
175	Product Information. Imitrex (sumatriptan). Glaxo Wellcome, Research Triangle Park, NC.
176	Product Information. Maxalt (rizatriptan). Merck & Co, Inc, West Point, PA.
177	Product Information. Zomig (zolmitriptan). Zeneca Pharmaceuticals, Wilmington, DE.
178	Product Information. Tyzine (tetrahydrozoline). Kenwood Laboratories, Fairfield, NJ.
179	Adverse effects and complications of treatment with beta-adrenergic agonist drugs. Committee on drugs, the American Academy of Allergy and Immunology. J Allergy Clin Immunol 75 (1985): 443-9. [PMID: 2858503]
180	Finch JS "Cardiovascular toxicity: clinical evaluation of albuterol, isoproterenol and placebo in rising dose tolerance trial." Ann Allergy 47 (1981): 402-4. [PMID: 7030155]
181	Product Information. Alupent (metaproterenol). Boehringer-Ingelheim, Ridgefield, CT.
182	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
183	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
184	Product Information. Brethaire (terbutaline). Novartis Pharmaceuticals, East Hanover, NJ.
185	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
186	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
187	Product Information. Isuprel (isoproterenol). Sanofi Winthrop Pharmaceuticals, New York, NY.
188	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
189	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
190	Product Information. S2 Inhalant (racepinephrine). Nephron Pharmaceuticals, Orlando, FL.
191	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
192	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
193	Product Information. Tornalate Metered Dose (bitolterol). Dura Pharmaceuticals, San Diego, CA.
194	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
195	Coleman AL, Robin AL, Pollack IP, Rudikoff MT, Enger C, Mayer PR "Cardiovascular and intraocular pressure effects and plasma concentrations of apraclonidine." Arch Ophthalmol 108 (1990): 1264-7. [PMID: 2205182]
196	Kronig MH, Roose SP, Walsh BT, Woodring S, Glassman AH "Blood pressure effects of phenelzine." J Clin Psychopharmacol 3 (1983): 307-10. [PMID: 6630590]
197	Sherman GP, Walton CA "Adrenergic transmission and drug interaction." J Am Pharm Assoc 15 (1975): 86-90. [PMID: 234987]
198	Cusson JR, Goldenberg E, Larochelle P "Effect of a novel monoamine-oxidase inhibitor, moclobemide on the sensitivity to intravenous tyramine and norepinephrine in humans." J Clin Pharmacol 31 (1991): 462-7. [PMID: 2050833]
199	Thompson DS, Sweet RA, Marzula K, Peredes JC "Lack of interaction of monoamine oxidase inhibitors and epinephrine in an older patient." J Clin Psychopharmacol 17 (1997): 322-3. [PMID: 9241014]
200	Smookler S, Barmudez AJ "Hypertensive crisis resulting from an MAO inhibitor and an over-the counter appetite suppressant." Ann Emerg Med 11 (1982): 482-4. [PMID: 7114595]
201	Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
202	Gulati OD, Dave BT, Gokhale SD, Shah KM "Antagonism of adrenergic neuron blockade in hypertensive subjects." Clin Pharmacol Ther 7 (1966): 510-4. [PMID: 5939974]
203	Iversen LL "Inhibition of noradrenaline uptake by drugs." J Pharm Pharmacol 17 (1965): 62-4. [PMID: 14285701]
204	Lee CH, Strosberg AM, Warren LA "The importance of catecholamine uptake in the reversal of guenethidine blockade of adrenergic neurons." Res Commun Chem Pathol Pharmacol 30 (1980): 3-14. [PMID: 7433767]
205	Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
206	Filibeck DJ, Grimm D, Forman WB, Leidner BA "Metoclopramide-induced hypertensive crisis." Clin Pharm 3 (1984): 548-9. [PMID: 6541544]
207	Product Information. Reglan (metoclopramide). Wyeth-Ayerst Laboratories, Philadelphia, PA.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence