Details of Drug

Details of Drug

 Drug General Information (ID: D0994)
  Drug Name
Melatonin
  Drug Type Small molecule
  Drug Synonymous
73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; 5-Methoxy-N-acetyltryptamine; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melatol; Melovine; Melatonex; N-[2-(5-methoxyindol-3-yl)ethyl]acetamide; Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-; UNII-JL5DK93RCL; N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide; N-acetyl-5-methoxy-tryptamine; NSC 113928; CCRIS 3472; CHEMBL45; EINECS 200-797-7; JL5DK93RCL; Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)-; BRN 0205542; Circadin; Melapure; Melatonina; Posidorm; Vivitas; Night Rest; Pineal Hormone; Revital Melatonin; Rx Balance; Sleep Right; IN1244; M 5250; M1105; ML1; MT6; TNP00300; M-1200; M-1250; Mela-T; Melatonex, Melatonin; Melatonina (TN); NMR/14327425; Nature'S Harmony; PREVENTION 2 (MELATONIN); PREVENTION 3 (MELATONIN); PREVENTION 4 (MELATONIN); PREVENTION 5 (MELATONIN); PREVENTION 1 (MELATONIN) (PREVENTION 1); Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}; Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]-(6CI,8CI); N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide; Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-(9CI); Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}; Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-(9CI); 4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID; [3H]melatonin; N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
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  Disease Class 7A00-7A0Z: Insomnia
  Therapeutic Class Cns Stimulants
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C13H16N2O2
  InChI 1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
  InChIKey DRLFMBDRBRZALE-UHFFFAOYSA-N
  Canonical SMILES CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
  External Link
Pubchem ID 896
CAS Number 73-31-4
CHEBI ID 16796
TTD ID D0AN7B
INTEDE ID DR1018

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM024  Competitive inhibition of metabolic enzyme
BM038  Additive CNS depression effects
  Relation Graph
 Full list of drugs interacting with Melatonin
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  30
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Moderate    Inter Info   
[1], [2], [3]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Moderate    Inter Info   
[1]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Moderate    Inter Info   
[4]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[5]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[8]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[9]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[15]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[18]
D0231
 
Caffeine
 
C8H10N4O2
 
2519 
Minor    Inter Info   
[20]
D0337
 
Cimetidine
 
C10H16N6S
 
2756 
Minor    Inter Info   
[1]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Minor    Inter Info   
[1]
D0387
 
Conjugated estrogens
 
C18H21NaO5S
 
45357473 
Minor    Inter Info   
[1]
D0487
 
Diethylstilbestrol
 
C18H20O2
 
448537 
Minor    Inter Info   
[1]
D0606
 
Estradiol
 
C18H24O2
 
5757 
Minor    Inter Info   
[1]
D0609
 
Estrone
 
C18H22O2
 
5870 
Minor    Inter Info   
[1]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Minor    Inter Info   
[1], [21], [22]
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Minor    Inter Info   
[1]
D0251
 
Capmatinib
 
C23H17FN6O
 
25145656 
Minor    Inter Info   
[1]
D0605
 
Esterified estrogens
 
NA
 
NA
Minor    Inter Info   
[1]
D0610
 
Estrone sulfate
 
C18H22O5S
 
3001028 
Minor    Inter Info   
[1], [21], [22]
D0724
 
Givosiran
 
C78H139N11O30
 
119058042 
Minor    Inter Info   
[1]
D1011
 
Mestranol
 
C21H26O2
 
6291 
Minor    Inter Info   
[1], [21], [22]
D1160
 
Obeticholic acid
 
C26H44O4
 
447715 
Minor    Inter Info   
[1]
D1165
 
Ofloxacin
 
C18H20FN3O4
 
4583 
Minor    Inter Info   
[1]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Minor    Inter Info   
[1]
D1327
 
Prasterone enantate
 
C26H40O3
 
163331 
Minor    Inter Info   
[1], [21], [22]
D1370
 
Quinestrol
 
C25H32O2
 
9046 
Minor    Inter Info   
[1]
D1092
 
Moxifloxacin
 
C21H24FN3O4
 
152946 
Minor    Inter Info   
[1]
D1102
 
Nalidixic acid
 
C12H12N2O3
 
4421 
Minor    Inter Info   
[1]
D1155
 
Norfloxacin
 
C16H18FN3O3
 
4539 
Minor    Inter Info   
[1]
   CYP450 enzyme induction Drug Num:  7
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[6]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[1], [2], [14]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[1], [2], [15]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Moderate    Inter Info   
[16]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Moderate    Inter Info   
[1], [2], [17]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Minor    Inter Info   
[1]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Minor    Inter Info   
[1], [20]
   Competitive inhibition of metabolic enzyme Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1428
 
Ropivacaine
 
C17H26N2O
 
175805 
Minor    Inter Info   
[23]
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  22
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0201
 
Brexanolone
 
C21H34O2
 
92786 
Moderate    Inter Info   
[7]
D0790
 
Ifosfamide
 
C7H15Cl2N2O2P
 
3690 
Moderate    Inter Info   
[10], [11], [12]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[13]
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Minor    Inter Info   
[1], [19], [11]
D0317
 
Chlordiazepoxide
 
C16H14ClN3O
 
2712 
Minor    Inter Info   
[1], [19], [11]
D0365
 
Clorazepic acid
 
C16H11ClN2O3
 
2809 
Minor    Inter Info   
[1], [19], [11]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Minor    Inter Info   
[1], [19], [11]
D0679
 
Flurazepam
 
C21H23ClFN3O
 
3393 
Minor    Inter Info   
[1], [19], [11]
D0748
 
Halazepam
 
C17H12ClF3N2O
 
31640 
Minor    Inter Info   
[1], [19], [11]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Minor    Inter Info   
[1], [20]
D0951
 
Lorazepam
 
C15H10Cl2N2O2
 
3958 
Minor    Inter Info   
[1], [19], [11]
D0362
 
Clonazepam
 
C15H10ClN3O3
 
2802 
Minor    Inter Info   
[1], [19], [11]
D0604
 
Estazolam
 
C16H11ClN4
 
3261 
Minor    Inter Info   
[1], [19], [11]
D1367
 
Quazepam
 
C17H11ClF4N2S
 
4999 
Minor    Inter Info   
[1], [19], [11]
D1391
 
Remimazolam
 
C21H19BrN4O2
 
9867812 
Minor    Inter Info   
[1], [19], [11]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Minor    Inter Info   
[1], [19], [11]
D1197
 
Oxazepam
 
C15H11ClN2O2
 
4616 
Minor    Inter Info   
[1], [19], [11]
D1547
 
Temazepam
 
C16H13ClN2O2
 
5391 
Minor    Inter Info   
[1], [19], [11]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Minor    Inter Info   
[1], [20]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Minor    Inter Info   
[1], [19], [11]
D1716
 
Zaleplon
 
C17H15N5O
 
5719 
Minor    Inter Info   
[1], [19], [11]
D1729
 
Zolpidem
 
C19H21N3O
 
5732 
Minor    Inter Info   
[1], [19], [11]
References
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2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
4 Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
5 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
6 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
7 Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
8 Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
9 Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
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16 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
17 Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
18 Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
19 Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
20 Hartter S, Nordmark A, Rose DM, Bertilsson L, Tybring G, Laine K "Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity." Br J Clin Pharmacol 56 (2003): 679-682. [PMID: 14616429]
21 Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24. [PMID: 8751044]
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