Drug General Information (ID: DDISO9Q0CT)
  Drug Name Thioridazine Drug Info Melatonin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antipsychotic Agents Cns Stimulants
  Structure

 Mechanism of Thioridazine-Melatonin Interaction (Severity Level: Minor)
     Additive CNS depression effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Thioridazine Melatonin
      Mechanism CNS depression effects CNS depression effects
      Key Mechanism Factor 1
Factor Name CNS depression effects
Factor Description CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
      Mechanism Description
  • Additive CNS depression effects by the combination of Thioridazine and Melatonin 

References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Hartter S, Nordmark A, Rose DM, Bertilsson L, Tybring G, Laine K "Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity." Br J Clin Pharmacol 56 (2003): 679-682. [PMID: 14616429]