Drug General Information (ID: DDIJTWGM36)
Drug Name			Zaleplon		Drug Info		Melatonin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Cns Stimulants
Structure

Mechanism of Zaleplon-Melatonin Interaction (Severity Level: Minor)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Zaleplon				Melatonin
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Zaleplon and Melatonin

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
3	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]