Details of Drug

Drug General Information (ID: D0980)
Drug Name	Maraviroc
Drug Type	Small molecule
Drug Synonymous	376348-65-1; Selzentry; Celsentri; UK-427857; UK-427,857; UK 427857; UNII-MD6P741W8A; MD6P741W8A; CHEMBL256907; MVC; CHEMBL1201187; CHEBI:63608; 4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[321]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide; Isopropyl, 4,4-difluoro-N-((1S)-3-{(1R,3s,5S)-3-(3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl)-8-azabicyclo(321)octan-8-yl}-1-phenylpropyl)cyclohexanecarboxamide; Maraviroc [USAN]; Celsentri (TN); Celsentri(TM); PRO 140 & Maraviroc; Selzentry (TN); Selzentry(TM); UK-427,857 maraviroc (MVC); Exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[321]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide; PRO 140 (Anti-CCR5 monoclonal antibody) & exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[321]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide; 4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(321)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide; [3H]maraviroc Click to Show/Hide
Disease Class	1C60-1C62: Human immunodeficiency virus disease; CA22: Chronic obstructive pulmonary disease
Therapeutic Class	Anti-Hiv Agents
Structure
Structure	3D Structure		2D Structure
Formula	C29H41F2N5O
InChI	1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25?,26-/m0/s1
InChIKey	GSNHKUDZZFZSJB-HLMSNRGBSA-N
Canonical SMILES	CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
External Link
	Pubchem ID	3002977
	CAS Number	376348-65-1
	CHEBI ID	63608
	TTD ID	D0NR6S
	VARIDT ID	DR00730

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM042 Additive hypotensive effects BM055 Increased risk of hepatotoxicity
Relation Graph

Full list of drugs interacting with Maraviroc
Affected cellular transport
	Transporter inhibition					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[1]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[1]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[1]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[32], [75]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[76]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[1]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[1]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[1]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[32], [78]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[79]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[1]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[1]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[81]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[1]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 72
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[1]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[1]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[42], [43]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[1]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[62]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[1]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[28], [32], [67], [68], [69], [22], [70], [71], [72], [73]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[1]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[1]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[77]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[80]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[1]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[1]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[28], [32], [85], [86]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[1]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 42
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [1], [24], [25], [26], [27]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[28], [1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[28], [1]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[28], [1]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[28], [1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[28], [1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[28], [1]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[28], [1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[28], [1]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[28], [1]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[65]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[28], [1]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[28], [74]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[28], [1]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[28], [1]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[28], [1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[28], [1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[28], [1]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[28], [1]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[32], [82]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[28], [1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[28], [1]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[28], [1]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[28], [1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[28], [1]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[28], [1]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[28], [1]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[28], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[28], [1]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[28], [1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[28], [1]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[28], [1]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 119
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[1]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[1]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[1]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[1]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[1]
D0082		Amrinone	C10H9N3O	3698	Moderate		Inter Info	[1]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[1]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[1]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[1]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[1]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[1]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[1]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[1]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[1]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[1]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[1]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[1]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[1]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[1]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[1]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[1]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[1]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[1]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[1]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[1]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[1]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[1]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[1]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[1]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[1]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[1]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[1]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[1]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[1]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[1]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[1]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[1]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[1]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[1]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[1]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[1]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[1]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[1]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[1]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[1]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[1]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[1]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[1]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[1]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[1]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[1]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[1]
D0396		Cyclandelate	C17H24O3	2893	Moderate		Inter Info	[1]
D0860		Isosorbide	C6H10O4	12597	Moderate		Inter Info	[1]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[1]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[1]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[1]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[1]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[1]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[1]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[1]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[1]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[1]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[1]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[1]
D1067		Milrinone	C12H9N3O	4197	Moderate		Inter Info	[1]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[1]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[1]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[1]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[1]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[1]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[1]
D1223		Papaverine	C20H21NO4	4680	Moderate		Inter Info	[1]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[1]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[1]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[1]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[1]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[1]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[1]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[1]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[1]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[1]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[1]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[1]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[1]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[1]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[1]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[1]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[1]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[1]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[1]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[1]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[1]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[1]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[1]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[1]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[1]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[1]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[1]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[1]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[1]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[1]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[1]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[1]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[1]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[1]
D1668		Urea	CH4N2O	1176	Moderate		Inter Info	[1]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[1]
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[2], [3], [4]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[5]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[6]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[7]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[2], [3], [4]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[29], [30], [31], [28], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[41]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[28], [32], [44]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[45], [46], [47], [48]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[45], [46], [47], [48]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[29], [30], [31], [28], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[63]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[64]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[29], [30], [31], [28], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[32], [66]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[45], [46], [47], [48]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[32], [83]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[32], [84]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[87]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[29], [30], [31], [28], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[88], [89]

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88	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
89	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.

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