Details of Drug

Drug General Information (ID: D0964)
Drug Name	Lutetium Lu 177 dotatate
Drug Type	Small molecule
Disease Class	1E50-1E51: Hepatitis virus infection
Therapeutic Class	Therapeutic Radiopharmaceuticals
Structure
Structure	3D Structure		2D Structure
Formula	C65H87LuN14O19S2
InChI	1S/C65H90N14O19S2.Lu/c1-38(80)56-64(96)73-51(63(95)75-57(39(2)81)65(97)98)37-100-99-36-50(72-59(91)47(28-40-10-4-3-5-11-40)68-52(83)32-76-20-22-77(33-53(84)85)24-26-79(35-55(88)89)27-25-78(23-21-76)34-54(86)87)62(94)70-48(29-41-15-17-43(82)18-16-41)60(92)71-49(30-42-31-67-45-13-7-6-12-44(42)45)61(93)69-46(58(90)74-56)14-8-9-19-66;/h3-7,10-13,15-18,31,38-39,46-51,56-57,67,80-82H,8-9,14,19-30,32-37,66H2,1-2H3,(H,68,83)(H,69,93)(H,70,94)(H,71,92)(H,72,91)(H,73,96)(H,74,90)(H,75,95)(H,84,85)(H,86,87)(H,88,89)(H,97,98);/q;+3/p-3/t38-,39-,46+,47-,48+,49-,50+,51+,56+,57+;/m1./s1/i;1+2
InChIKey	MXDPZUIOZWKRAA-PRDSJKGBSA-K
Canonical SMILES	CC(C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)CN6CCN(CCN(CCN(CC6)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-])C(=O)NC(C(C)O)C(=O)O)O.[Lu+3]
External Link
	Pubchem ID	76966897
	CAS Number	437608-50-9
	TTD ID	D0M5VV

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM027 Decreased renal excretion due to nephrotoxicity BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM072 Increased risk of nephrotoxicity BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens
Relation Graph

Full list of drugs interacting with Lutetium Lu 177 dotatate
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[87]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[87]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[87]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[74]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[79]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[108]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[113]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[10], [11], [12]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[11], [14]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[31]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[40]
D1111		Natalizumab	NA	NA	Major		Inter Info	[42]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[11], [43]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [46]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[48]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[38], [49], [50]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[52], [53], [54]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[10], [11]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[52], [53], [54]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [11], [67]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [11], [67]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[69]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[70]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[71]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[70]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[70]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[104]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[105]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[11], [106]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[107]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[109]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[52], [53], [54]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[11], [110]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[111]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[10], [11], [112]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[116]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[118]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[10], [11], [119]
	Additive myelosuppressive effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[11], [15], [16]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[10], [19], [20]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[45]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[51]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[10], [11], [80], [81]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[10], [11], [80], [81]
	Increased risk of hepatotoxicity					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[35]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[36]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[41]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[44]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[35]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[61]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[62]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[11], [66]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[68]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[72], [73]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[10], [11], [75]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[82]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[83], [84], [85], [86]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[83], [84], [85], [86]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[10], [11], [98], [99], [100]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[11], [102]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[103]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[83], [84], [85], [86]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[114], [115]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[11], [117]
	Increased risk of nephrotoxicity					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[13]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[17], [18]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[21], [22], [23], [24], [25], [26], [27]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[28], [29], [30]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[32], [33], [34]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[32], [33], [34]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[32], [33], [34]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[23], [24], [25]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[21], [22], [23], [24], [25], [26], [27]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[21], [22], [23], [24], [25], [26], [27]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[21], [22], [23], [24], [25], [26], [27]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[23], [24], [25]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[23], [24], [25]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[21], [22], [23], [24], [25], [26], [27]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[23], [24], [25]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[32], [33], [34]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[11], [37]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[28], [29], [30]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[28], [29], [30]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[28], [29], [30]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[57], [58], [59], [60]
D0421		Daptomycin	C72H101N17O26	16134395	Moderate		Inter Info	[11]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[76], [77], [78]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[58], [59], [60]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[11]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[57], [58], [59], [60]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[76], [77], [78]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[57], [58], [59], [60]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[120], [121], [122], [77], [123], [124], [125], [126], [127], [128], [78], [129]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[38], [10], [39]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[7], [8], [9]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[7], [8], [9]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[47]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[7], [8], [9]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[38], [55], [56]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[38], [55], [56]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[38], [55], [56]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[38], [55], [56]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[38], [55], [56]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[38], [55], [56]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[38], [55], [56]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[91], [38], [10], [92], [93], [94], [55], [95], [96], [97], [56]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[38], [55], [56]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[38], [55], [56]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[101]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[38], [55], [56]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[38], [55], [56]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[88], [89], [90]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[88], [89], [90]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[63], [64], [65]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[63], [64], [65]

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