Details of Drug

Drug General Information (ID: D0948)
Drug Name	Lopinavir
Drug Type	Small molecule
Drug Synonymous	AIDS032937; Aluvia (TN); Aluviran; Kaletra (TN); Koletra; LPV; Lopinavir (JAN/USAN/INN); Lopinavir [USAN:INN:BAN]; RS-346; A 157378; A 157378.0; A-157378-0; A-157378.0; ABT 157378; ABT 378; ABT-378; ABT-378 Click to Show/Hide
Disease Class	1C60-1C62: Human immunodeficiency virus disease
Therapeutic Class	Anti-Hiv Agents
Structure
Structure	3D Structure		2D Structure
Formula	C37H48N4O5
InChI	1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
InChIKey	KJHKTHWMRKYKJE-SUGCFTRWSA-N
Canonical SMILES	CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O
External Link
	Pubchem ID	92727
	CAS Number	192725-17-0
	CHEBI ID	31781
	TTD ID	D0U5GB
	INTEDE ID	DR0976
	VARIDT ID	DR00290

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM051 Increased risk of bradycardia BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM086 Antagonize the effect of antidiabetic agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Lopinavir
Affected gastrointestinal absorption
	Complex formation					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[1], [74], [3]
Affected cellular transport
	Transporter inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1301		Pitavastatin	C25H24FNO4	5282452	Major		Inter Info	[38], [39], [40]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Major		Inter Info	[39], [55], [17]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[81], [82], [83]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Minor		Inter Info	[5], [92], [3]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[5], [92], [3]
D0367		Clotrimazole	C22H17ClN2	2812	Minor		Inter Info	[5], [92], [3]
D0416		Danazol	C22H27NO2	28417	Minor		Inter Info	[5], [92], [3]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[5], [92], [3]
D1457		Selexipag	C26H32N4O4S	9913767	Minor		Inter Info	[93], [3], [94]
	CYP450 enzyme induction					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[9], [4], [3]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1], [5], [3]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[4], [5], [22]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [47], [3]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[48], [3], [49]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[4], [5], [22]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[81], [82], [83]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[4], [3], [36]
Pharmacodynamic additive effects
	Increased risk of bradycardia					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[75], [76], [77]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[3], [80]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[75], [76], [77]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[75], [76], [77]
	Increased risk of prolong QT interval					Drug Num: 81
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[4], [5], [6]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[10], [11], [12]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [13], [14]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [5], [15]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [4], [5]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[16], [3], [17]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [18], [15]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[19], [20], [21]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[23], [1], [24]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[4], [5], [25]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [26], [27]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[4], [5], [28]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[29], [3], [17]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[30]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[10], [11], [12]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[34], [35], [36]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[4], [5], [37]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[4], [5], [41]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [4], [42]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[4], [5], [43]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[44], [45], [46]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[23], [1], [24]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[50], [51], [52]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [53], [54]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[56], [57], [58]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [53], [54]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[59], [60], [61]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [4], [62]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[5], [63], [64]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[1], [4], [3]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[1], [4], [3]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[5], [63], [64]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1], [4], [3]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[1], [4], [3]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[4], [5], [78]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1], [4], [3]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[1], [4], [3]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[1], [4], [3]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[5], [63], [64]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[1], [4], [3]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[1], [4], [3]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[5], [63], [64]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[1], [4], [3]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[1], [4], [3]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[1], [4], [3]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[5], [63], [64]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[1], [4], [3]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[5], [63], [64]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[1], [4], [3]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[1], [4], [3]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[1], [4], [3]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[5], [63], [64]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[1], [4], [3]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[1], [4], [3]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[1], [4], [3]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[1], [4], [3]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1], [4], [3]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[1], [4], [3]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[1], [4], [3]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[1], [4], [3]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[1], [4], [3]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[5], [63], [64]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[1], [4], [3]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[5], [63], [64]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[1], [4], [3]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[1], [4], [3]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[1], [4], [3]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[1], [4], [3]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[1], [4], [3]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[1], [4], [3]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[1], [4], [3]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[1], [4], [3]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[86], [87], [36]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1], [4], [3]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[1], [4], [3]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[88], [89], [90]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[1], [4], [3]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[1], [4], [3]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1], [4], [3]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[1], [4], [3]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[1], [4], [3]
	Increased risk of ventricular arrhythmias					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[7], [3], [8]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[1], [4], [33]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[68], [69], [70]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[71], [72], [73]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[71], [72], [73]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[71], [72], [73]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[71], [72], [73]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[4], [5], [79]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[4], [5], [79]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[4], [5], [79]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[4], [5], [79]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[4], [5], [79]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[71], [72], [73]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[4], [5], [79]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[71], [72], [73]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[4], [5], [79]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[4], [5], [79]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[71], [72], [73]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[4], [5], [79]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[5], [84], [85]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[4], [5], [79]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[71], [72], [73]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[71], [72], [73]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[71], [72], [73]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[71], [72], [73]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[71], [72], [73]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[4], [5], [91]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[65], [66], [67]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[65], [66], [67]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[65], [66], [67]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[4], [31], [32]

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