Details of Drug-Drug Interaction
| Drug General Information (ID: DDIMANFJQ9) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Saquinavir | Drug Info | Lopinavir | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Anti-Hiv Agents | Anti-Hiv Agents | |||||||
| Structure | |||||||||
| Mechanism of Saquinavir-Lopinavir Interaction (Severity Level: Major) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Saquinavir | Lopinavir | |||||||
| Mechanism | Prolong QT interval | Prolong QT interval | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | QT interval | ||||||||
| Factor Description | Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | The product labeling for saquinavir and lopinavir-ritonavir both recommend that these medications not be used with other agents that can prolong the QT interval. Whether they should be used with each other is unknown, but coadministration may increase the risk of QT and PR prolongation and should preferably be avoided if possible. If concomitant use is necessary, the recommended dosages are saquinavir 1000 mg twice daily and lopinavir-ritonavir 400 mg-100 mg twice daily. Once-daily dosing of lopinavir-ritonavir has not been studied for use in combination with saquinavir. Patients should be advised to notify their physician if they experience dizziness, lightheadedness, fainting, palpitations, syncope, and/or irregular heartbeat. | ||||||||