Drug General Information (ID: D0868)
  Drug Name
Ivabradine
  Drug Type Small molecule
  Drug Synonymous
Ivabradine; 155974-00-8; Procoralan; Corlanor; Corlentor; UNII-3H48L0LPZQ; S 16257; S-16257; S-16257-2; S 16257-2; 3H48L0LPZQ; CHEMBL471737; CHEBI:85966; C27H36N2O5; 7,8-Dimethoxy-3-(3-(((4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one; S-16260-2; s16257; (S)-3-(3-(((3,4-Dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one; Ivabradine [INN]
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  Disease Class BA40: Angina pectoris
  Therapeutic Class Cardiovascular Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C27H36N2O5
  InChI 1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1
  InChIKey ACRHBAYQBXXRTO-OAQYLSRUSA-N
  Canonical SMILES CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC
  External Link
Pubchem ID 132999
CAS Number 155974-00-8
CHEBI ID 85966
TTD ID D0S9QA

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM049  Increased risk of atrioventricular block
BM051  Increased risk of bradycardia
BM076  Increased risk of prolong QT interval
BM081  Increased risk of ventricular arrhythmias
  Relation Graph
 Full list of drugs interacting with Ivabradine
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  55
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Major    Inter Info   
[4], [1], [3], [5]
D0100
 
Aprepitant
 
C23H21F7N4O3
 
135413536 
Major    Inter Info   
[1], [6], [3]
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Major    Inter Info   
[4], [1], [3], [5]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Major    Inter Info   
[4], [1], [3], [5]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Major    Inter Info   
[4], [1], [3], [5]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Major    Inter Info   
[4], [1], [3], [5]
D0367
 
Clotrimazole
 
C22H17ClN2
 
2812 
Major    Inter Info   
[1], [6], [3]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Major    Inter Info   
[4], [1], [3], [5]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Major    Inter Info   
[4], [1], [3], [5]
D0413
 
Dalfopristin
 
C34H50N4O9S
 
6323289 
Major    Inter Info   
[1], [9], [3]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Major    Inter Info   
[4], [1], [6], [3]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Major    Inter Info   
[4], [1], [3], [5]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Major    Inter Info   
[4], [1], [3], [5]
D0693
 
Fosaprepitant
 
C23H22F7N4O6P
 
135413538 
Major    Inter Info   
[1], [6], [3]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Major    Inter Info   
[4], [1], [3], [5]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Major    Inter Info   
[1], [6], [3]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Major    Inter Info   
[1], [6], [3]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Major    Inter Info   
[4], [1], [3], [5]
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Major    Inter Info   
[1], [6], [3]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Major    Inter Info   
[1], [6], [3]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Major    Inter Info   
[1], [6], [3]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Major    Inter Info   
[8]
D0906
 
Letermovir
 
C29H28F4N4O4
 
45138674 
Major    Inter Info   
[1], [6], [3]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Major    Inter Info   
[8]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Major    Inter Info   
[1], [6], [3]
D1653
 
Troleandomycin
 
C41H67NO15
 
202225 
Major    Inter Info   
[4], [1], [3], [5]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Major    Inter Info   
[4], [1], [3], [5]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Major    Inter Info   
[4], [1], [3], [5]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Major    Inter Info   
[4], [1], [3], [5]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Major    Inter Info   
[8]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Major    Inter Info   
[4], [1], [3], [5]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Major    Inter Info   
[4], [1], [3], [5]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Major    Inter Info   
[4], [1], [3], [5]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Major    Inter Info   
[4], [1], [3], [5]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Major    Inter Info   
[4], [1], [3], [5]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Major    Inter Info   
[4], [1], [3], [5]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Major    Inter Info   
[4], [1], [3], [5]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Major    Inter Info   
[4], [1], [3], [5]
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Moderate    Inter Info   
[1], [3]
D0337
 
Cimetidine
 
C10H16N6S
 
2756 
Moderate    Inter Info   
[1], [3]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Moderate    Inter Info   
[1], [3]
D0416
 
Danazol
 
C22H27NO2
 
28417 
Moderate    Inter Info   
[1], [3]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Moderate    Inter Info   
[1], [3]
D0858
 
Isoniazid
 
C6H7N3O
 
3767 
Moderate    Inter Info   
[1], [3]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[53]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[58]
D0735
 
Goldenseal
 
NA
 
NA
Moderate    Inter Info   
[1], [3]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[1], [3]
D0901
 
Lemborexant
 
C22H20F2N4O2
 
56944144 
Moderate    Inter Info   
[1], [3]
D1709
 
Voxelotor
 
C19H19N3O3
 
71602803 
Moderate    Inter Info   
[1], [3]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Moderate    Inter Info   
[1], [3]
D0944
 
Lomitapide
 
C39H37F6N3O2
 
9853053 
Moderate    Inter Info   
[1], [3]
D1214
 
Palbociclib
 
C24H29N7O2
 
5330286 
Moderate    Inter Info   
[1], [3]
D1524
 
Suvorexant
 
C23H23ClN6O2
 
24965990 
Moderate    Inter Info   
[1], [3]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Moderate    Inter Info   
[1], [3]
   CYP450 enzyme induction Drug Num:  45
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Major    Inter Info   
[1], [7], [3]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Major    Inter Info   
[1], [7], [3]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Major    Inter Info   
[1], [7], [3]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Major    Inter Info   
[1], [7], [3]
D0958
 
Lumacaftor
 
C24H18F2N2O5
 
16678941 
Major    Inter Info   
[1], [7], [3]
D1078
 
Mitotane
 
C14H10Cl4
 
4211 
Major    Inter Info   
[1], [7], [3]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Major    Inter Info   
[1], [7], [3]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Major    Inter Info   
[1], [7], [3]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Major    Inter Info   
[1], [7], [3]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Major    Inter Info   
[1], [7], [3]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Major    Inter Info   
[1], [7], [3]
D1502
 
St. John's Wort
 
NA
 
NA
Major    Inter Info   
[1], [7], [3]
D0061
 
Aminoglutethimide
 
C13H16N2O2
 
2145 
Moderate    Inter Info   
[1], [3]
D0071
 
Amobarbital
 
C11H18N2O3
 
2164 
Moderate    Inter Info   
[1], [3]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Moderate    Inter Info   
[1], [3]
D0178
 
Bexarotene
 
C24H28O2
 
82146 
Moderate    Inter Info   
[1], [3]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[1], [3]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[1], [3]
D0225
 
Butalbital
 
C11H16N2O3
 
2481 
Moderate    Inter Info   
[1], [3]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[1], [3]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Moderate    Inter Info   
[1], [3]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[1], [3]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[1], [3]
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Moderate    Inter Info   
[1], [3]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[1], [3]
D0741
 
Griseofulvin
 
C17H17ClO6
 
441140 
Moderate    Inter Info   
[1], [3]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[4], [57]
D0555
 
Elagolix
 
C32H30F5N3O5
 
11250647 
Moderate    Inter Info   
[1], [3]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[1], [3]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[1], [3]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Moderate    Inter Info   
[1], [3]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[4], [1], [60]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[4], [1], [61], [60]
D1538
 
Tazemetostat
 
C34H44N4O4
 
66558664 
Moderate    Inter Info   
[1], [3]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Moderate    Inter Info   
[1], [62]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[1], [3]
D1050
 
Metreleptin
 
NA
 
NA
Moderate    Inter Info   
[1], [3]
D1099
 
Nafcillin
 
C21H22N2O5S
 
8982 
Moderate    Inter Info   
[1], [3]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[1], [3]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[1], [3]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[1], [3]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[1], [3]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[1], [3]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Moderate    Inter Info   
[1], [3]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[1], [3]
      Pharmacodynamic additive effects
   Increased risk of bradycardia Drug Num:  53
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0497
 
Diltiazem
 
C22H26N2O4S
 
39186 
Major    Inter Info   
[1], [2], [3], [10]
D1474
 
Siponimod
 
C29H35F3N2O3
 
44599207 
Major    Inter Info   
[4], [12]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Major    Inter Info   
[1], [2], [3], [10]
D0010
 
Acebutolol
 
C18H28N2O4
 
1978 
Moderate    Inter Info   
[4], [3]
D0052
 
Ambenonium
 
C28H42Cl2N4O2+2
 
2131 
Moderate    Inter Info   
[4], [3]
D0117
 
Atenolol
 
C14H22N2O3
 
2249 
Moderate    Inter Info   
[4], [3]
D0173
 
Betaxolol
 
C18H29NO3
 
2369 
Moderate    Inter Info   
[4], [3]
D0174
 
Betaxolol (ophthalmic)
 
C18H29NO3
 
2369 
Moderate    Inter Info   
[4], [3]
D0265
 
Carteolol
 
C16H24N2O3
 
2583 
Moderate    Inter Info   
[4], [3]
D0266
 
Carteolol (ophthalmic)
 
C16H24N2O3
 
2583 
Moderate    Inter Info   
[4], [3]
D0267
 
Carvedilol
 
C24H26N2O4
 
2585 
Moderate    Inter Info   
[4], [3]
D0352
 
Clevidipine
 
C21H23Cl2NO6
 
153994 
Moderate    Inter Info   
[4], [3]
D0440
 
Demecarium (ophthalmic)
 
C32H52N4O4+2
 
5966 
Moderate    Inter Info   
[4], [3]
D0490
 
Digitoxin
 
C41H64O13
 
441207 
Moderate    Inter Info   
[4], [3]
D0491
 
Digoxin
 
C41H64O14
 
2724385 
Moderate    Inter Info   
[4], [3]
D0516
 
Donepezil
 
C24H29NO3
 
3152 
Moderate    Inter Info   
[4], [3]
D0546
 
Echothiophate (ophthalmic)
 
C9H23NO3PS+
 
10548 
Moderate    Inter Info   
[4], [3]
D0552
 
Edrophonium
 
C10H16NO+
 
3202 
Moderate    Inter Info   
[4], [3]
D0602
 
Esmolol
 
C16H25NO4
 
59768 
Moderate    Inter Info   
[4], [3]
D0636
 
Famotidine
 
C8H15N7O2S3
 
5702160 
Moderate    Inter Info   
[4], [3]
D0661
 
Fingolimod
 
C19H33NO2
 
107970 
Moderate    Inter Info   
[51], [52]
D0707
 
Galantamine
 
C17H21NO3
 
9651 
Moderate    Inter Info   
[4], [3]
D0856
 
Isoflurophate (ophthalmic)
 
C6H14FO3P
 
5936 
Moderate    Inter Info   
[4], [3]
D0865
 
Isradipine
 
C19H21N3O5
 
3784 
Moderate    Inter Info   
[4], [3]
D0031
 
Alectinib
 
C30H34N4O2
 
49806720 
Moderate    Inter Info   
[54], [55]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[56]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[59]
D0911
 
Levamlodipine
 
C20H25ClN2O5
 
9822750 
Moderate    Inter Info   
[4], [3]
D0914
 
Levobetaxolol (ophthalmic)
 
C18H29NO3
 
60657 
Moderate    Inter Info   
[4], [3]
D0884
 
Labetalol
 
C19H24N2O3
 
3869 
Moderate    Inter Info   
[4], [3]
D0885
 
Lacosamide
 
C13H18N2O3
 
219078 
Moderate    Inter Info   
[4], [3]
D0915
 
Levobunolol (ophthalmic)
 
C17H25NO3
 
39468 
Moderate    Inter Info   
[4], [3]
D1045
 
Metipranolol (ophthalmic)
 
C17H27NO4
 
31477 
Moderate    Inter Info   
[4], [3]
D1049
 
Metoprolol
 
C15H25NO3
 
4171 
Moderate    Inter Info   
[4], [3]
D1098
 
Nadolol
 
C17H27NO4
 
39147 
Moderate    Inter Info   
[4], [3]
D1114
 
Nebivolol
 
C22H25F2NO4
 
71301 
Moderate    Inter Info   
[4], [3]
D1122
 
Neostigmine
 
C12H19N2O2+
 
4456 
Moderate    Inter Info   
[4], [3]
D1130
 
Nicardipine
 
C26H29N3O6
 
4474 
Moderate    Inter Info   
[4], [3]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Moderate    Inter Info   
[4], [3]
D1138
 
Nimodipine
 
C21H26N2O7
 
4497 
Moderate    Inter Info   
[4], [3]
D1141
 
Nisoldipine
 
C20H24N2O6
 
4499 
Moderate    Inter Info   
[4], [3]
D1151
 
Nizatidine
 
C12H21N5O2S2
 
3033637 
Moderate    Inter Info   
[4], [3]
D1244
 
Penbutolol
 
C18H29NO2
 
37464 
Moderate    Inter Info   
[4], [3]
D1285
 
Physostigmine
 
C15H21N3O2
 
5983 
Moderate    Inter Info   
[4], [3]
D1286
 
Physostigmine (ophthalmic)
 
C15H21N3O2
 
5983 
Moderate    Inter Info   
[4], [3]
D1288
 
Pilocarpine
 
C11H16N2O2
 
5910 
Moderate    Inter Info   
[4], [3]
D1293
 
Pindolol
 
C14H20N2O2
 
4828 
Moderate    Inter Info   
[4], [3]
D1357
 
Propranolol
 
C16H21NO2
 
4946 
Moderate    Inter Info   
[4], [3]
D1381
 
Ranitidine
 
C13H22N4O3S
 
3001055 
Moderate    Inter Info   
[4], [3]
D1418
 
Rivastigmine
 
C14H22N2O2
 
77991 
Moderate    Inter Info   
[4], [3]
D1525
 
Tacrine
 
C13H14N2
 
1935 
Moderate    Inter Info   
[4], [3]
D1585
 
Timolol
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[4], [3]
D1586
 
Timolol (ophthalmic)
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[4], [3]
   Increased risk of prolong QT interval Drug Num:  2
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0003
 
Abarelix
 
C72H95ClN14O14
 
16131215 
Major    Inter Info   
[1], [2], [3]
D1223
 
Papaverine
 
C20H21NO4
 
4680 
Major    Inter Info   
[13], [14], [15], [16], [17], [18], [19], [20]
   Increased risk of ventricular arrhythmias Drug Num:  172
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0007
 
Abiraterone
 
C24H31NO
 
132971 
Major    Inter Info   
[1], [2], [3]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Major    Inter Info   
[1], [2], [3]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Major    Inter Info   
[1], [2], [3]
D0067
 
Amisulpride
 
C17H27N3O4S
 
2159 
Major    Inter Info   
[1], [2], [3]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Major    Inter Info   
[1], [2], [3]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Major    Inter Info   
[1], [2], [3]
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Major    Inter Info   
[1], [2], [3]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Major    Inter Info   
[1], [2], [3]
D0107
 
Arsenic trioxide
 
As2O3
 
14888 
Major    Inter Info   
[1], [2], [3]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Major    Inter Info   
[1], [2], [3]
D0115
 
Astemizole
 
C28H31FN4O
 
2247 
Major    Inter Info   
[1], [2], [3]
D0119
 
Atomoxetine
 
C17H21NO
 
54841 
Major    Inter Info   
[1], [2], [3]
D0139
 
Azithromycin
 
C38H72N2O12
 
447043 
Major    Inter Info   
[1], [2], [3]
D0149
 
Bedaquiline
 
C32H31BrN2O2
 
5388906 
Major    Inter Info   
[1], [2], [3]
D0170
 
Bepridil
 
C24H34N2O
 
2351 
Major    Inter Info   
[1], [2], [3]
D0180
 
Bicalutamide
 
C18H14F4N2O4S
 
2375 
Major    Inter Info   
[1], [2], [3]
D0195
 
Bosutinib
 
C26H29Cl2N5O3
 
5328940 
Major    Inter Info   
[1], [2], [3]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Major    Inter Info   
[1], [2], [3]
D0230
 
Cabozantinib
 
C28H24FN3O5
 
25102847 
Major    Inter Info   
[1], [2], [3]
D0320
 
Chloroquine
 
C18H26ClN3
 
2719 
Major    Inter Info   
[1], [2], [3]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Major    Inter Info   
[1], [2], [3]
D0336
 
Cilostazol
 
C20H27N5O2
 
2754 
Major    Inter Info   
[1], [2], [3]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Major    Inter Info   
[1], [2], [3]
D0342
 
Cisapride
 
C23H29ClFN3O4
 
6917698 
Major    Inter Info   
[1], [2], [3]
D0358
 
Clofazimine
 
C27H22Cl2N4
 
2794 
Major    Inter Info   
[1], [2], [3]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Major    Inter Info   
[1], [2], [3]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Major    Inter Info   
[8]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Major    Inter Info   
[1], [2], [3]
D0429
 
Daunorubicin
 
C27H29NO10
 
30323 
Major    Inter Info   
[1], [2], [3]
D0430
 
Daunorubicin (liposomal)
 
C27H29NO10
 
30323 
Major    Inter Info   
[1], [2], [3]
D0437
 
Degarelix
 
C82H103ClN18O16
 
16136245 
Major    Inter Info   
[1], [2], [3]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Major    Inter Info   
[1], [2], [3]
D0467
 
Dextropropoxyphene
 
C22H29NO2
 
10100 
Major    Inter Info   
[1], [2], [3]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Major    Inter Info   
[1], [2], [3]
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Major    Inter Info   
[1], [2], [3]
D0514
 
Dolasetron
 
C19H20N2O3
 
3033818 
Major    Inter Info   
[1], [2], [3]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Major    Inter Info   
[1], [2], [3]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Major    Inter Info   
[1], [2], [3]
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Major    Inter Info   
[1], [2], [3]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Major    Inter Info   
[1], [2], [3]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Major    Inter Info   
[8]
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Major    Inter Info   
[1], [2], [3]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Major    Inter Info   
[1], [2], [3]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Major    Inter Info   
[1], [2], [3]
D0594
 
Eribulin
 
C40H59NO11
 
11354606 
Major    Inter Info   
[1], [2], [3]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Major    Inter Info   
[1], [2], [3]
D0632
 
Ezogabine
 
C16H18FN3O2
 
121892 
Major    Inter Info   
[1], [2], [3]
D0664
 
Flecainide
 
C17H20F6N2O3
 
3356 
Major    Inter Info   
[1], [2], [3]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Major    Inter Info   
[1], [2], [3]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Major    Inter Info   
[1], [2], [3]
D0682
 
Flutamide
 
C11H11F3N2O3
 
3397 
Major    Inter Info   
[1], [2], [3]
D0694
 
Foscarnet
 
CH3O5P
 
3415 
Major    Inter Info   
[1], [2], [3]
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Major    Inter Info   
[1], [2], [3]
D0716
 
Gemifloxacin
 
C18H20FN5O4
 
9571107 
Major    Inter Info   
[1], [2], [3]
D0737
 
Goserelin
 
C59H84N18O14
 
5311128 
Major    Inter Info   
[1], [2], [3]
D0738
 
Granisetron
 
C18H24N4O
 
5284566 
Major    Inter Info   
[1], [2], [3]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Major    Inter Info   
[1], [2], [3]
D0749
 
Halofantrine
 
C26H30Cl2F3NO
 
37393 
Major    Inter Info   
[1], [2], [3]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Major    Inter Info   
[1], [2], [3]
D0751
 
Halothane
 
C2HBrClF3
 
3562 
Major    Inter Info   
[1], [2], [3]
D0758
 
Histrelin
 
C66H86N18O12
 
25077993 
Major    Inter Info   
[1], [2], [3]
D0779
 
Hydroxychloroquine
 
C18H26ClN3O
 
3652 
Major    Inter Info   
[1], [2], [3]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Major    Inter Info   
[1], [2], [3]
D0787
 
Ibutilide
 
C20H36N2O3S
 
60753 
Major    Inter Info   
[1], [2], [3]
D0788
 
Idarubicin
 
C26H27NO9
 
42890 
Major    Inter Info   
[1], [2], [3]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Major    Inter Info   
[1], [2], [3]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Major    Inter Info   
[1], [2], [3]
D0806
 
Inotuzumab ozogamicin
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D0452
 
Deutetrabenazine
 
C19H27NO3
 
73437646 
Major    Inter Info   
[1], [2], [3]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Major    Inter Info   
[1], [2], [3]
D0700
 
Fostemsavir
 
C25H26N7O8P
 
11319217 
Major    Inter Info   
[1], [2], [3]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Major    Inter Info   
[1], [2], [3]
D0725
 
Glasdegib
 
C21H22N6O
 
25166913 
Major    Inter Info   
[1], [2], [3]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Major    Inter Info   
[1], [2], [3]
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Major    Inter Info   
[1], [2], [3]
D0965
 
Macimorelin
 
C26H30N6O3
 
9804938 
Major    Inter Info   
[1], [2], [3]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Major    Inter Info   
[1], [2], [3]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Major    Inter Info   
[1], [2], [3]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Major    Inter Info   
[1], [2], [3]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[11]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Major    Inter Info   
[1], [2], [3]
D1388
 
Relugolix
 
C29H27F2N7O5S
 
10348973 
Major    Inter Info   
[1], [2], [3]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Major    Inter Info   
[1], [2], [3]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Major    Inter Info   
[1], [2], [3]
D1634
 
Triclabendazole
 
C14H9Cl3N2OS
 
50248 
Major    Inter Info   
[1], [2], [3]
D1673
 
Valbenazine
 
C24H38N2O4
 
24795069 
Major    Inter Info   
[1], [2], [3]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Major    Inter Info   
[1], [2], [3]
D0903
 
Lenvatinib
 
C21H19ClN4O4
 
9823820 
Major    Inter Info   
[1], [2], [3]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Major    Inter Info   
[1], [2], [3]
D0919
 
Levofloxacin
 
C18H20FN3O4
 
149096 
Major    Inter Info   
[1], [2], [3]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Major    Inter Info   
[1], [2], [3]
D0942
 
Lofexidine
 
C11H12Cl2N2O
 
30668 
Major    Inter Info   
[1], [2], [3]
D0943
 
Lomefloxacin
 
C17H19F2N3O3
 
3948 
Major    Inter Info   
[1], [2], [3]
D0960
 
Lumefantrine
 
C30H32Cl3NO
 
6437380 
Major    Inter Info   
[1], [2], [3]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Major    Inter Info   
[1], [2], [3]
D0992
 
Mefloquine
 
C17H16F6N2O
 
4046 
Major    Inter Info   
[1], [2], [3]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Major    Inter Info   
[1], [2], [3]
D1017
 
Methadone
 
C21H27NO
 
4095 
Major    Inter Info   
[1], [2], [3]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Major    Inter Info   
[1], [2], [3]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Major    Inter Info   
[1], [2], [3]
D1075
 
Mirtazapine
 
C17H19N3
 
4205 
Major    Inter Info   
[1], [2], [3]
D1092
 
Moxifloxacin
 
C21H24FN3O4
 
152946 
Major    Inter Info   
[1], [2], [3]
D1137
 
Nilutamide
 
C12H10F3N3O4
 
4493 
Major    Inter Info   
[1], [2], [3]
D1155
 
Norfloxacin
 
C16H18FN3O3
 
4539 
Major    Inter Info   
[1], [2], [3]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Major    Inter Info   
[1], [2], [3]
D1165
 
Ofloxacin
 
C18H20FN3O4
 
4583 
Major    Inter Info   
[1], [2], [3]
D1181
 
Ondansetron
 
C18H19N3O
 
4595 
Major    Inter Info   
[1], [2], [3]
D1193
 
Oxaliplatin
 
C8H14N2O4Pt
 
9887053 
Major    Inter Info   
[1], [2], [3]
D1210
 
Oxytocin
 
C43H66N12O12S2
 
439302 
Major    Inter Info   
[1], [2], [3]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Major    Inter Info   
[1], [2], [3]
D1216
 
Palonosetron
 
C19H24N2O
 
6337614 
Major    Inter Info   
[1], [2], [3]
D1221
 
Panobinostat
 
C21H23N3O2
 
6918837 
Major    Inter Info   
[1], [2], [3]
D1230
 
Pasireotide
 
C58H66N10O9
 
9941444 
Major    Inter Info   
[1], [2], [3]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Major    Inter Info   
[1], [2], [3]
D1246
 
Pentamidine
 
C19H24N4O2
 
4735 
Major    Inter Info   
[1], [2], [3]
D1254
 
Perflutren
 
C3F8
 
6432 
Major    Inter Info   
[1], [2], [3]
D1290
 
Pimavanserin
 
C25H34FN3O2
 
10071196 
Major    Inter Info   
[1], [2], [3]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Major    Inter Info   
[1], [2], [3]
D1339
 
Primaquine
 
C15H21N3O
 
4908 
Major    Inter Info   
[1], [2], [3]
D1342
 
Probucol
 
C31H48O2S2
 
4912 
Major    Inter Info   
[1], [2], [3]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Major    Inter Info   
[1], [2], [3]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Major    Inter Info   
[1], [2], [3]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Major    Inter Info   
[1], [2], [3]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Major    Inter Info   
[1], [2], [3]
D1353
 
Propafenone
 
C21H27NO3
 
4932 
Major    Inter Info   
[1], [2], [3]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Major    Inter Info   
[1], [2], [3]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Major    Inter Info   
[1], [2], [3]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Major    Inter Info   
[1], [2], [3]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Major    Inter Info   
[1], [2], [3]
D1404
 
Rilpivirine
 
C22H18N6
 
6451164 
Major    Inter Info   
[1], [2], [3]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Major    Inter Info   
[1], [2], [3]
D1424
 
Romidepsin
 
C24H36N4O6S2
 
5352062 
Major    Inter Info   
[1], [2], [3]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Major    Inter Info   
[1], [2], [3]
D1463
 
Sevoflurane
 
C4H3F7O
 
5206 
Major    Inter Info   
[1], [2], [3]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Major    Inter Info   
[1], [2], [3]
D1497
 
Sorafenib
 
C21H16ClF3N4O3
 
216239 
Major    Inter Info   
[1], [2], [3]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Major    Inter Info   
[1], [2], [3]
D1499
 
Sparfloxacin
 
C19H22F2N4O3
 
60464 
Major    Inter Info   
[1], [2], [3]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Major    Inter Info   
[1], [2], [3]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Major    Inter Info   
[1], [2], [3]
D1542
 
Telavancin
 
C80H106Cl2N11O27P
 
3081362 
Major    Inter Info   
[1], [2], [3]
D1555
 
Terfenadine
 
C32H41NO2
 
5405 
Major    Inter Info   
[1], [2], [3]
D1560
 
Tetrabenazine
 
C19H27NO3
 
6018 
Major    Inter Info   
[1], [2], [3]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Major    Inter Info   
[1], [2], [3]
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Major    Inter Info   
[1], [2], [3]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[1], [2], [3]
D1624
 
Trazodone
 
C19H22ClN5O
 
5533 
Major    Inter Info   
[1], [2], [3]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Major    Inter Info   
[1], [2], [3]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Major    Inter Info   
[1], [2], [3]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Major    Inter Info   
[1], [2], [3]
D1651
 
Triptorelin
 
C64H82N18O13
 
25074470 
Major    Inter Info   
[1], [2], [3]
D1681
 
Vandetanib
 
C22H24BrFN4O2
 
3081361 
Major    Inter Info   
[1], [2], [3]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Major    Inter Info   
[1], [2], [3]
D1683
 
Vasopressin
 
C46H65N15O12S2
 
644077 
Major    Inter Info   
[1], [2], [3]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Major    Inter Info   
[1], [2], [3]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Major    Inter Info   
[1], [2], [3]
D1726
 
Ziprasidone
 
C21H21ClN4OS
 
60854 
Major    Inter Info   
[1], [2], [3]
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Moderate    Inter Info   
[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0691
 
Formoterol
 
C19H24N2O4
 
3410 
Moderate    Inter Info   
[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Moderate    Inter Info   
[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Moderate    Inter Info   
[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Moderate    Inter Info   
[34], [44], [47]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Moderate    Inter Info   
[34], [44], [47]
D1171
 
Olodaterol
 
C21H26N2O5
 
11504295 
Moderate    Inter Info   
[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Moderate    Inter Info   
[34], [44], [47]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Moderate    Inter Info   
[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Moderate    Inter Info   
[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[34], [44], [47]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Moderate    Inter Info   
[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Moderate    Inter Info   
[4], [1], [63]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Moderate    Inter Info   
[34], [44], [47]
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