Details of Drug-Drug Interaction
| Drug General Information (ID: DDIUN635SX) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Carteolol (ophthalmic) | Drug Info | Ivabradine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antihypertensive Agents | Cardiovascular Agents | |||||||
| Structure | |||||||||
| Mechanism of Carteolol (ophthalmic)-Ivabradine Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of bradycardia Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Carteolol (ophthalmic) | Ivabradine | |||||||
| Mechanism | Bradycardia | Bradycardia | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Bradycardia | ||||||||
| Factor Description | Bradycardia is a slow heart rate in which the heart beats less than 60 times per minute. If the heart rate is very slow and the heart is not pumping enough oxygen-rich blood to the body, and you may feel dizzy, very tired or weak, and short of breath. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution is advised when ivabradine is prescribed with other bradycardic drugs. Heart rate should be closely monitored, and the dosage of ivabradine adjusted accordingly. Patients should be advised to report significant decreases in heart rate or symptoms such as dizziness, lightheadedness, fatigue, and hypotension. | ||||||||
| References | |||||||||||||||||||
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| 1 | Cerner Multum, Inc. "Australian Product Information.". | ||||||||||||||||||
| 2 | Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA. | ||||||||||||||||||