Details of Drug

Drug General Information (ID: D0867)
Drug Name	Itraconazole
Drug Type	Small molecule
Drug Synonymous	Canadiol; Hyphanox; ITCZ; ITZ; Intraconazole; Itraconazol; Itraconazolum; Itrizole; Oriconazole; Orungal; Prokanazol; Sempera; Spherazole; Sporal; Sporanos; Sporanox; Sporonox; Triasporn; Itraconazol [Spanish]; Itraconazole oral solution; Itraconazolum [Latin]; R 51211; Cis-Itraconazole; Itraconazole & Bovine Lactoferrin; Itraconazole & Nyotran; Itrizole (TN); R-51211; Sporanox (TN); Itraconazole & Nyotran(Liposomal Nystatin); Itraconazole (JAN/USAN); Oriconazole, R51211, Sporanox; Itraconazole [USAN:BAN:INN:JAN]; (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one; (1)-cis-4-(4-(4-(4-((2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2,4-dihydro-2-sec-butyl-3H-1,2,4-triazol-3-one; 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one; 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; 2-butan-2-yl-4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-pipera-zinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl); 4-(4-{4-[4-({[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}oxy)phenyl]piperazin-1-yl}phenyl)-2-(1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one Click to Show/Hide
Disease Class	1F29-1F2F: Fungal infection
Therapeutic Class	Antifungal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C35H38Cl2N8O4
InChI	1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1
InChIKey	VHVPQPYKVGDNFY-ZPGVKDDISA-N
Canonical SMILES	CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
External Link
	Pubchem ID	55283
	CAS Number	84625-61-6
	CHEBI ID	6076
	TTD ID	D0V4IB
	INTEDE ID	DR0895
	VARIDT ID	DR00687

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM005 Altered gastric pH BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions BM076 Increased risk of prolong QT interval BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Itraconazole
Affected gastrointestinal absorption
	Complex formation					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0893		Lanthanum carbonate	C3La2O9	168924	Moderate		Inter Info	[63], [19], [64], [671], [672], [673]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[64], [599]
	Altered gastric pH					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[590], [418], [591], [25]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[606], [607]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[617], [618], [619], [620], [621], [622], [623], [624], [625], [626], [627], [628]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[590], [418], [591], [25]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[351], [618], [418], [24], [628]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[617], [618], [619], [620], [621], [622], [623], [624], [625], [626], [627], [628]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[351], [618], [418], [24], [628]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[351], [618], [418], [24], [628]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[351], [618], [418], [24], [628]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[351], [618], [418], [24], [628]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[351], [618], [418], [24], [628]
D1489		Sodium zirconium cyclosilicate	H6Na2O9Si3Zr+2	91799284	Moderate		Inter Info	[64], [695]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[617], [618], [619], [620], [621], [622], [623], [624], [625], [626], [627], [628]
D1151		Nizatidine	C12H21N5O2S2	3033637	Moderate		Inter Info	[590], [418], [591], [25]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[617], [618], [619], [620], [621], [622], [623], [624], [625], [626], [627], [628]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[617], [618], [619], [620], [621], [622], [623], [624], [625], [626], [627], [628]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[590], [418], [591], [25]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[590], [418], [25]
Affected cellular transport
	Transporter inhibition					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Major		Inter Info	[106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[175]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[176], [177], [178]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[64], [235], [236], [237]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[346]
D1408		Riociguat	C20H19FN8O2	11304743	Major		Inter Info	[19], [64], [363], [24]
D1532		Talazoparib	C19H14F2N6O	135565082	Major		Inter Info	[64], [375]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[599], [600], [601], [602]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[599], [601], [602]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[19], [64], [648]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[667]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[19], [64], [24]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[599], [600], [601], [602]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[674]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[677]
D0656		Fexofenadine	C32H39NO4	3348	Minor		Inter Info	[759], [760]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[19], [64], [769]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 325
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D0045		Alprazolam	C17H13ClN4	2118	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[36], [37], [38]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[40], [41], [19], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [25], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[71]
D0303		Cerivastatin	C26H34FNO5	446156	Major		Inter Info	[72], [73], [65], [74], [75], [66], [67], [76], [68], [77], [78], [69], [79], [80]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[64], [81], [82], [83]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[84], [85], [19], [86], [43], [87], [88], [89], [48], [50], [51], [90], [24], [25], [52]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[19], [91], [24], [92]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[19], [64], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103]
D0424		Darifenacin	C28H30N2O2	444031	Major		Inter Info	[19], [104], [105], [24]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[118], [119], [120], [121], [19], [43], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [51], [24], [135], [136], [137], [138], [139], [140]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[63], [19], [64], [141], [24], [25]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[63], [19], [64], [24], [142]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[143]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[19], [144], [24]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[118], [119], [120], [121], [19], [43], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [51], [24], [135], [136], [137], [138], [139], [140]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[145], [146]
D0612		Eszopiclone	C17H17ClN6O3	969472	Major		Inter Info	[147], [148], [43], [149], [150]
D0640		Felodipine	C18H19Cl2NO4	3333	Major		Inter Info	[151], [152], [50], [24], [39], [153], [154]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[19], [155], [156], [157], [24], [158], [13]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[64], [159]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[160], [161]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[63], [19], [64], [162], [163], [50], [164], [24]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[63], [162], [164]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[165]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[166]
D0038		Aliskiren	C30H53N3O6	5493444	Major		Inter Info	[19], [24], [167], [168]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[19], [64], [170], [24]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[19], [24], [171]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[64], [172]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[19], [64], [173], [24]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[160], [161], [174]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[19], [64], [179], [24]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[180]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[181]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[182], [19], [64], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[19], [64], [196], [24]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[197]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[198]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[19], [199], [24]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[200], [201], [202], [19], [64], [203], [204], [205], [206], [207], [208], [209], [210], [192], [24], [193], [211], [212], [213], [214], [215], [216], [217]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[218]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[19], [24], [219]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[64], [220]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[19], [24], [221]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[64], [222]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[223], [19], [64], [224], [225], [24], [226], [227], [228], [229]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[19], [230], [24]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[19], [64], [231], [232], [233], [193], [234]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[238]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[19], [64], [239], [24]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[64], [240], [241], [242]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[243]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[120], [19], [124]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[64], [244]
D0655		Fesoterodine	C26H37NO3	6918558	Major		Inter Info	[19], [24], [25], [245]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[246]
D0683		Fluticasone	C22H27F3O4S	5311101	Major		Inter Info	[247], [248], [249], [250], [183], [251], [252], [253], [254], [255], [256], [257], [258], [188], [259], [260], [261], [190], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Major		Inter Info	[270], [271], [283]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[284]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[285]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[286]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[64], [287]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[288], [289], [290], [291], [292]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[19], [293], [24]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[19], [64], [294], [24]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[295]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[19], [64], [296], [24]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[19], [64], [297], [298], [299], [300]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[301]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[19], [24], [302]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[19], [64], [303]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[304]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[19], [305]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[306], [307]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[308]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[19], [309], [24]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[307]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[310]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[311]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[19], [64], [312], [24]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[313]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[314]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[315]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[316], [317]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[19], [64], [319], [24]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[320], [19], [321]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[19], [24], [322]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[19], [64], [323], [24]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[324], [325]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[64], [326]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[327]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[328], [329]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[19], [24], [330]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[64], [331]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[332]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[333]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[334]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[19], [64], [335]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[336]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[337], [338], [339], [340], [341], [342], [343], [344], [345]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[64], [347]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[19], [364]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[19], [64], [365], [24], [366]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[367]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[64], [368]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[369]
D1466		Silodosin	C25H32F3N3O4	5312125	Major		Inter Info	[19], [370], [24]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[19], [371], [24]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[19], [372]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[19], [64], [24], [25], [373]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[19], [374]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[376]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[19], [64], [380], [24]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[19], [91], [24], [92]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[19], [64], [381], [24], [382]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[383]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[384]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[386]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[19], [24], [387]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[388]
D0947		Loperamide	C29H33ClN2O2	3955	Major		Inter Info	[389], [390], [391], [392], [393], [394]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[63], [19], [64], [395], [65], [67], [76], [68], [78], [69], [24]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[19], [396], [24]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[120], [19], [124]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[397], [398], [399], [400], [401], [402], [403], [404]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[120], [19], [124]
D1060		Midazolam	C18H13ClFN3	4192	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[405], [406]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[407]
D1141		Nisoldipine	C20H24N2O6	4499	Major		Inter Info	[19], [64], [408], [151], [152], [50], [24], [39], [153], [154]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[19], [64], [409]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[19], [410], [43], [411], [412], [413], [414], [415], [24]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[19], [64], [416], [417], [418], [419], [420], [421], [48], [50], [51], [422], [24], [25], [52], [423], [424], [425]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[19], [64], [426], [24]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[427], [270], [428]
D1440		Salmeterol	C25H37NO4	5152	Major		Inter Info	[19], [64], [429], [24]
D1465		Sildenafil	C22H30N6O4S	135398744	Major		Inter Info	[19], [64], [430], [431], [432], [433], [434], [435], [24], [436], [437]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[63], [19], [64], [395], [65], [67], [76], [68], [78], [69], [24]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[19], [438], [439], [440], [51], [441], [24], [52], [193]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[442], [443], [444], [445], [446], [19], [64], [439], [447], [448], [449], [450], [451], [452], [453], [454], [51], [455], [52], [456], [457], [60], [458]
D1534		Tamsulosin	C20H28N2O5S	129211	Major		Inter Info	[19], [459], [460], [461], [24]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[462], [25], [463]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[40], [41], [464], [19], [465], [43], [466], [46], [467], [468], [469], [470], [471], [472], [473], [474], [475], [47], [48], [50], [51], [476], [25], [52], [54], [57], [60], [62], [477], [478], [479]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[480]
D1626		Tretinoin	C20H28O2	444795	Major		Inter Info	[481], [482], [483], [484], [485], [486], [487], [488], [489], [490], [491]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[397], [492], [493], [398], [494], [495], [496], [497], [498], [499], [500], [501]
D1632		Triazolam	C17H12Cl2N4	5556	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[19], [502], [24]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[503], [504], [505], [506], [507], [508], [63], [509], [19], [64], [510], [511], [512], [513], [514], [515], [516], [517], [518], [519], [520], [521], [522], [523], [524], [525], [526], [527], [528], [529], [24], [530], [531], [532], [533], [534], [535], [536], [537], [538], [539]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[503], [504], [505], [506], [507], [508], [63], [509], [19], [64], [510], [511], [512], [513], [514], [515], [516], [517], [518], [519], [520], [521], [522], [523], [524], [525], [526], [527], [528], [529], [24], [530], [531], [532], [533], [534], [535], [536], [537], [538], [539]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[506], [528], [530]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[503], [504], [505], [506], [507], [508], [63], [509], [19], [64], [510], [511], [512], [513], [514], [515], [516], [517], [518], [519], [520], [521], [522], [523], [524], [525], [526], [527], [528], [529], [24], [530], [531], [532], [533], [534], [535], [536], [537], [538], [539]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[543]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[544]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[545], [546], [547], [548], [549]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[550], [551], [552]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[351], [553], [554], [555], [556], [557], [558]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[559], [560]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[397], [248], [182], [572], [573], [186], [398], [574], [575], [399], [255], [256], [576], [400], [401], [402], [577], [189], [578], [194], [195], [275], [579], [403], [404], [580], [581], [582], [282]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[583], [584], [585]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[586]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[587]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[589]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[19]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[592]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[25], [593]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[540], [19], [419]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[540], [19], [419]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[595], [591], [596], [52], [597], [598]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[591], [596], [598]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[603], [604], [294], [48], [50], [51], [24], [605], [52]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[351], [555], [557]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[591], [596], [598]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[595], [591], [596], [52], [597], [598]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[63], [64], [608]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[397], [563], [19], [64], [609], [610], [611]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[612]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[615], [616]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[595], [591], [596], [52], [597], [598]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[591], [596], [598]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[595], [591], [596], [52], [597], [598]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[591], [596], [598]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[595], [591], [596], [52], [597], [598]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[397], [248], [182], [572], [573], [186], [398], [574], [575], [399], [255], [256], [576], [400], [401], [402], [577], [189], [578], [194], [195], [275], [579], [403], [404], [580], [581], [582], [282]
D0672		Flunisolide	C24H31FO6	82153	Moderate		Inter Info	[397], [248], [182], [572], [573], [186], [398], [574], [575], [399], [255], [256], [576], [400], [401], [402], [577], [189], [578], [194], [195], [275], [579], [403], [404], [580], [581], [582], [282]
D0673		Flunisolide (nasal)	C24H31FO6	82153	Moderate		Inter Info	[186], [574], [275]
D0674		Fluorometholone (ophthalmic)	C22H29FO4	9878	Moderate		Inter Info	[186], [574], [275]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[630], [631]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[632]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[615], [633]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[634]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[635]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[397], [248], [182], [572], [573], [186], [398], [574], [575], [399], [255], [256], [576], [400], [401], [402], [577], [189], [578], [194], [195], [275], [579], [403], [404], [580], [581], [582], [282]
D0774		Hydrocortisone (ophthalmic)	C21H30O5	5754	Moderate		Inter Info	[186], [574], [275]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[636]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[545], [546], [547], [548], [549]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[637]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[643]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[645]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[64]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[646]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[19], [64], [647]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[192], [193]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[52], [219], [649]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[182], [19], [64]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[19], [650], [24]
D0333		Ciclesonide	C32H44O7	6918155	Moderate		Inter Info	[397], [398], [652], [653]
D0334		Ciclesonide (nasal)	C32H44O7	6918155	Moderate		Inter Info	[654], [655], [652]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[540], [24]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[656]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[657]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[658]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[659]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[19], [64], [660]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[661], [662]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[397], [248], [182], [572], [573], [186], [398], [574], [575], [399], [255], [256], [576], [400], [401], [402], [577], [189], [578], [194], [195], [275], [579], [403], [404], [580], [581], [582], [282]
D0454		Dexamethasone (nasal)	C22H29FO5	5743	Moderate		Inter Info	[186], [574], [275]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Moderate		Inter Info	[186], [574], [275]
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[664]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[595], [591], [596], [52], [597], [598]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[591], [596], [598]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[591], [596], [598]
D0660		Finasteride	C23H36N2O2	57363	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[550], [551], [552]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[559], [560]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[19]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[669]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[19], [64], [670]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[64], [675]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[676]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[595], [591], [596], [52], [597], [598]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[678]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[679], [680], [19], [681], [682], [683], [684], [227]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[679], [680], [19]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[19], [64], [686]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[64]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[687], [688]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[595], [591], [596], [52], [597], [598]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[19], [24], [689]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[691]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[692]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[674]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[64], [694]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[19], [24], [698]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[699]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[192], [193]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[19], [701], [24]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[540], [24]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[702]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[703]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[267], [649], [280]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[64], [704]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[64], [705]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D0955		Loteprednol (ophthalmic)	C21H27ClO5	9865442	Moderate		Inter Info	[186], [574], [275]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[591], [596], [598]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[708], [709], [325], [710], [711]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[63], [19], [64]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[591], [596], [598]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[617], [618], [619], [620], [418], [621], [622], [624], [625], [626], [627], [628]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[64], [716]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[397], [248], [182], [572], [573], [186], [398], [574], [575], [399], [255], [256], [576], [400], [401], [402], [577], [189], [578], [194], [195], [275], [579], [403], [404], [580], [581], [582], [282]
D1333		Prednisolone (ophthalmic)	C21H28O5	5755	Moderate		Inter Info	[186], [574], [275]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[397], [248], [182], [572], [573], [186], [398], [574], [575], [399], [255], [256], [576], [400], [401], [402], [577], [189], [578], [194], [195], [275], [579], [403], [404], [580], [581], [582], [282]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[595], [591], [596], [52], [597], [598]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[591], [596], [598]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[19], [64], [719], [720], [721], [722], [723], [724], [725], [726], [727]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[728]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[19], [729], [730], [24]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[540], [19], [419]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[733]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[734], [735]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[736], [737], [738], [739], [740], [551], [637], [741], [552], [270], [742], [660], [743], [657], [744]
D1629		Triamcinolone (nasal)	C21H27FO6	31307	Moderate		Inter Info	[186], [574], [275]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[186], [574], [275]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[745]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[19], [64], [52]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[351], [553], [554], [555], [556], [557], [558]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[540], [19], [541], [515], [419], [542], [24], [153], [404]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[746], [747], [748], [749], [750], [270], [751]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[752], [753]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[757], [758]
D0007		Abiraterone	C24H31NO	132971	Minor		Inter Info	[761]
D0053		Ambrisentan	C22H22N2O4	6918493	Minor		Inter Info	[762]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[19], [763], [764]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[64], [765]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[766]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[767]
D0589		Eravacycline	C27H31FN4O8	54726192	Minor		Inter Info	[768]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[757], [758]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Minor		Inter Info	[770]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[771]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[772]
D1253		Perampanel	C23H15N3O	9924495	Minor		Inter Info	[64], [773]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[774]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Minor		Inter Info	[775], [776]
D0950		Loratadine	C22H23ClN2O2	3957	Minor		Inter Info	[777], [642], [778], [779]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[19], [763], [764]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[780]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[781], [782], [783], [784], [785], [786], [787]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[788]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[789], [790], [791], [792]
	CYP450 enzyme induction					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[348], [349], [350], [351], [19], [64], [352], [353], [354], [355], [356], [357], [358], [50], [24], [359], [360], [361], [362]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[19], [24], [377]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[348], [349], [350], [351], [19], [64], [352], [353], [354], [355], [356], [357], [358], [50], [24], [359], [360], [361], [362]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[351], [354], [361]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[442], [19], [24], [359], [588], [361]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[19], [24], [613]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[19], [64], [629], [24]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[19], [642], [24]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[64], [644]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[651]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[19], [663]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[665], [19], [64], [666]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[19], [64], [629], [24]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[19], [642], [24]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[64], [685]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[690]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[64], [693]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[19], [64], [696]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[19], [64], [697], [696]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[64], [700]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[19], [64], [629], [24]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[713], [714], [715]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[19], [64], [629], [24]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[19], [64], [696]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[19], [24], [39]
D0865		Isradipine	C19H21N3O5	3784	Major		Inter Info	[19], [24], [39]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[19], [24], [39]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Major		Inter Info	[19], [24], [39]
D1130		Nicardipine	C26H29N3O6	4474	Major		Inter Info	[19], [24], [39]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[19], [24], [39]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[19], [24], [39]
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[385]
	Increased risk of hepatotoxicity					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[318]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[63], [378], [379]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[561], [562], [563], [19], [64], [564], [565], [566], [567], [568], [569], [570], [571]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[594]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[19], [64], [614]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[638], [639], [640], [641]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[638], [639], [640], [641]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[561], [562], [563], [19], [64], [564], [565], [566], [567], [568], [569], [570], [571]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[561], [562], [563], [19], [64], [564], [565], [566], [567], [568], [569], [570], [571]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[668]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[638], [639], [640], [641]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[64], [707]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[712]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[561], [562], [563], [19], [64], [564], [565], [566], [567], [568], [569], [570], [571]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[731], [732]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[717], [64], [718]
	Increased risk of prolong QT interval					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[19], [64], [169]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[19], [24], [706]
D0075		Amphotericin B	C47H73NO17	5280965	Minor		Inter Info	[754], [755], [756]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Minor		Inter Info	[754], [755], [756]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Minor		Inter Info	[754], [755], [756]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Minor		Inter Info	[754], [755], [756]

References
1	Bartkowski RR, Goldberg ME, Larijani GE, Boerner T "Inhibition of alfentanil metabolism by erythromycin." Clin Pharmacol Ther 46 (1989): 99-102. [PMID: 2501060]
2	Bartkowski RR, McDonnell TE "Prolonged alfentanil effect following erythromycin administration." Anesthesiology 73 (1990): 566-8. [PMID: 2203286]
3	Kharasch ED, Thummel KE "Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?" Anesth Analg 76 (1993): 1033-9. [PMID: 8484504]
4	Kharasch ED, Walker A, Hoffer C, Sheffels P "Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis." Clin Pharmacol Ther 76 (2004): 452-66. [PMID: 15536460]
5	Klees TM, Sheffels P, Dale O, Kharasch ED "Metabolism of alfentanil by cytochrome P4503A enzymes." Drug Metab Dispos 33 (2005): 303-11. [PMID: 15557344]
6	Klees TM, Sheffels P, Thummel KE, Kharasch ED "Pharmacogenetic Determinants of Human Liver Microsomal Alfentanil Metabolism and the Role of Cytochrome P450 3A5." Anesthesiology 102 (2005): 550-556. [PMID: 15731592]
7	Koehntop DE, Noormohamed SE, Fletcher CV "Effects of long-term drugs on alfentanil clearance in patients undergoing renal transplantation." Pharmacotherapy 14 (1994): 592-9. [PMID: 7997393]
8	Labroo RB, Thummel KE, Kunze KL, Podoll T, Trager WF, Kharasch ED "Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism." Drug Metab Dispos 23 (1995): 490-6. [PMID: 7600917]
9	Palkama VJ, Isohanni MH, Neuvonen PJ, Olkkola KT "The effect of intravenous and oral fluconazole on the pharmacokinetics and pharmacodynamics of intravenous alfentanil." Anesth Analg 87 (1998): 190-4. [PMID: 9661572]
10	Product Information. Alfenta (alfentanil). Janssen Pharmaceutica, Titusville, NJ.
11	Yate PM, Thomas D, Short SM, Sebel PS, Morton J "Comparison of infusions of alfentanil or pethidine for sedation of ventilated patients on the ITU." Br J Anaesth 58 (1986): 1091-9. [PMID: 2876719]
12	Yun CH, Wood M, Wood AJ, Guengerich FP "Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4: an explanation of the variable elimination clearance." Anesthesiology 77 (1992): 467-74. [PMID: 1519785]
13	Ibrahim AE, Feldman J, Karim A, Kharasch ED "Simultaneous Assessment of Drug Interactions with Low- and High-Extraction Opioids: Application to Parecoxib Effects on the Pharmacokinetics and Pharmacodynamics of Fentanyl and Alfentanil." Anesthesiology 98 (2003): 853-861. [PMID: 12657846]
14	Kharasch ED, Russell M, Mautz D, Thummel KE, Kunze KL, Bowdle A, Cox K "The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions." Anesthesiology 87 (1997): 36-50. [PMID: 9232132]
15	Ahonen J, Olkkola KT, Neuvonen PJ "Effect of itraconazole and terbinafine on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers." Br J Clin Pharmacol 40 (1995): 270-2. [PMID: 8527290]
16	Ahonen J, Olkkola KT, Neuvonen PJ "Lack of effect of antimycotic itraconazole on the pharmacokinetics or pharmacodynamics of temazepam." Ther Drug Monit 18 (1996): 124-7. [PMID: 8721273]
17	Backman JT, Kivisto KT, Olkkola KT, Neuvonen PJ "The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin." Eur J Clin Pharmacol 54 (1998): 53-8. [PMID: 9591931]
18	Brown MW, Maldonado AL, Meredith CG, Speeg KV "Effect of ketoconazole on hepatic oxidative drug metabolism." Clin Pharmacol Ther 37 (1985): 290-7. [PMID: 3971653]
19	Cerner Multum, Inc. "Australian Product Information.".
20	Greenblatt DJ, Vonmoltke LL, Harmatz JS, Harrel LM, Tobias S, Shader RI, Wright CE "Interaction of triazolam and ketoconazole." Lancet 345 (1995): 191. [PMID: 7823684]
21	Neuvonen PJ, Varhe A, Olkkola KT "The effect of ingestion time interval on the interaction between itraconazole and triazolam." Clin Pharmacol Ther 60 (1996): 326-31. [PMID: 8841155]
22	Olkkola KT, Backman JT, Neuvonen PJ "Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole." Clin Pharmacol Ther 55 (1994): 481-5. [PMID: 8181191]
23	Product Information. Halcion (triazolam). Pharmacia and Upjohn, Kalamazoo, MI.
24	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
25	Product Information. Sporonox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
26	Product Information. Versed (midazolam). Roche Laboratories, Nutley, NJ.
27	Product Information. Xanax (alprazolam). Pharmacia and Upjohn, Kalamazoo, MI.
28	Tsunoda SM, Velez RL, vonMoltke LL, Greenblatt DJ "Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: Effect of ketoconazole." Clin Pharmacol Ther 66 (1999): 461-71. [PMID: 10579473]
29	Varhe A, Olkkola KT, Neuvonen PJ "Fluconazole, but not terbinafine, enhances the effects of triazolam by inhibiting its metabolism." Br J Clin Pharmacol 41 (1996): 319-23. [PMID: 8730978]
30	Varhe A, Olkkola KT, Neuvonen PJ "Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole." Clin Pharmacol Ther 56 (1994): 601-7. [PMID: 7995001]
31	Vonmoltke LL, Greenblatt DJ, Cotreaubibbo MM, Harmatz JS, Shader RI "Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine." Br J Clin Pharmacol 38 (1994): 23-31. [PMID: 7946933]
32	Vonmoltke LL, Greenblatt DJ, Schmider J, Duan SX, Wright CE, Harmatz JS, Shader RI "Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents." J Clin Pharmacol 36 (1996): 783-91. [PMID: 8889898]
33	Wrighton SA, Ring BJ "Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine." Pharm Res 11 (1994): 921-4. [PMID: 7937537]
34	Yasui N, Kondo T, Otani K, Furukori H, Kaneko S, Ohkubo T, Nagasaki T, Sugawara K "Effect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of alprazolam." Psychopharmacology 139 (1998): 269-73. [PMID: 9784084]
35	Greenblatt DJ, Wright CE, vonMoltke LL, Harmatz JS, Ehrenberg BL, Harrel LM, Corbett K, Counihan M, Tobias S, Shader RI "Ketoconazole inhibition of triazolam and alprazolam clearance: Differential kinetic and dynamic consequences." Clin Pharmacol Ther 64 (1998): 237-47. [PMID: 9757147]
36	Fabre G, Julian B, Saint-Aubert B, Joyeux H, Berger Y "Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions." Drug Metab Dispos 21 (1993): 978-85. [PMID: 7905403]
37	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
38	Product Information. Cordarone Intravenous (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
39	Rosen T "Debilitating edema associated with itraconazole therapy." Arch Dermatol 130 (1994): 260-1. [PMID: 8304774]
40	Ament PW, Paterson A "Drug interactions with the nonsedating antihistamines." Am Fam Physician 56 (1997): 223. [PMID: 9225677]
41	Berul CI, Morad M "Regulation of potassium channels by nonsedating antihistamines." Circulation 91 (1995): 2220-5. [PMID: 7697852]
42	Craft TM "Torsade de pointes after astemizole overdose." Br Med J 292 (1986): 660. [PMID: 2868774]
43	Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57. [PMID: 10668858]
44	Goss JE, Ramo BW, Blake K "Torsades de pointes associated with astemizole (hismanal) therapy." Arch Intern Med 153 (1993): 2705. [PMID: 8250668]
45	Heidemann SM, Sarnaik AP "Arrhythmias after astemizole overdose." Pediatr Emerg Care 12 (1996): 102-4. [PMID: 8859918]
46	Honig PK, Cantilena LR "Ketoconazole and fluconazole drug interactions." Arch Intern Med 154 (1994): 1038-41. [PMID: 8179450]
47	Pratt CM, Mason J, Russell T, Reynolds R, Ahlbrandt R "Cardiovascular safety of fexofenadine HCl." Am J Cardiol 83 (1999): 1451-4. [PMID: 10335761]
48	Product Information. Diflucan (fluconazole). Roerig Division, New York, NY.
49	Product Information. Hismanal (astemizole). Janssen Pharmaceutica, Titusville, NJ.
50	Product Information. Nizoral (ketoconazole). Janssen Pharmaceutica, Titusville, NJ. (1992):.
51	Product Information. Noxafil (posaconazole). Schering-Plough Corporation, Kenilworth, NJ.
52	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
53	Rao KA, Adlakha A, Vermaansil B, Meloy TD, Stanton MS "Torsades de pointes ventricular tachycardia associated with overdose of astemizole." Mayo Clin Proc 69 (1994): 589-93. [PMID: 8189766]
54	Salata JJ, Jurkiewicz NK, Wallace AA, Stupienski RF, Guinosso PJ, Lynch JJ "Cardiac electrophysiological actions of the histamine h-1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine." Circ Res 76 (1995): 110-9. [PMID: 8001268]
55	Saviuc P, Danel V, Dixmerias F "Prolonged QT interval and torsade de pointes following astemizole overdose." J Toxicol Clin Toxicol 31 (1993): 121-5. [PMID: 8433408]
56	Simons FE, Kesselman MS, Giddins NG, Pelech AN, Simons KJ "Astemizole-induced torsade de pointes." Lancet 2 (1988): 624. [PMID: 2900995]
57	Smith SJ "Cardiovascular toxicity of antihistamines." Otolaryngol Head Neck Surg 111 Suppl (1994): 348-54. [PMID: 7916150]
58	Snook J, Boothman-Burrell D, Watkins J, Colin-Jones D "Torsade de pointes ventricular tachycardia associated with astemizole overdose." Br J Clin Pract 42 (1988): 257-9. [PMID: 2905156]
59	Tsai WC, Tsai LM, Chen JH "Combined use of astemizole and ketoconazole resulting in torsade de pointes." J Formos Med Assoc 96 (1997): 144-6. [PMID: 9071844]
60	Venkatakrishnan K, von Moltke LL, Greenblatt DJ "Effects of the antifungal agents on oxidative drug metabolism: clinical relevance." Clin Pharmacokinet 38 (2000): 111-80. [PMID: 10709776]
61	Vorperian VR, Zhou ZF, Mohammad S, Hoon TJ, Studenik C, January CT "Torsade de pointes with an antihistamine metabolite: potassium channel blockade with desmethylastemizole." J Am Coll Cardiol 28 (1996): 1556-61. [PMID: 8917271]
62	Woosley RL "Cardiac actions of antihistamines." Annu Rev Pharmacol Toxicol 36 (1996): 233-52. [PMID: 8725389]
63	Canadian Pharmacists Association.
64	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
65	Horn M "Coadministration of itraconazole with hypolipidemic agents may induce rhabdomyolysis in healthy individuals." Arch Dermatol 132 (1996): 1254. [PMID: 8859048]
66	Kantola T, Kivisto KT, Neuvonen PJ "Effect of itraconazole on the pharmacokinetics of atorvastatin." Clin Pharmacol Ther 64 (1998): 58-65. [PMID: 9695720]
67	Kivisto KT, Kantola T, Neuvonen PJ "Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin." Br J Clin Pharmacol 46 (1998): 49-53. [PMID: 9690949]
68	Lomaestro BM, Piatek MA "Update on drug interactions with azole antifungal agents." Ann Pharmacother 32 (1998): 915-28. [PMID: 9762380]
69	Neuvonen PJ, Kantola T, Kivisto KT "Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole." Clin Pharmacol Ther 63 (1998): 332-41. [PMID: 9542477]
70	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
71	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
72	Akram K, Rao S, Parker M "A lesson for everyone in drug-drug interactions." Int J Cardiol 118 (2007): e19-20. [PMID: 17368833]
73	Gilad R, Lampl Y "Rhabdomyolysis induced by simvastatin and ketoconazole treatment." Clin Neuropharmacol 22 (1999): 295-7. [PMID: 10516882]
74	Itakura H, Vaughn D, Haller DG, O'Dwyer PJ "Rhabdomyolysis from cytochrome p-450 interaction of ketoconazole and simvastatin in prostate cancer." J Urol 169 (2003): 613. [PMID: 12544321]
75	Kantola T, Kivisto KT, Neuvonen PJ "Effect of itraconazole on cerivastatin pharmacokinetics." Eur J Clin Pharmacol 54 (1999): 851-5. [PMID: 10027660]
76	Lees RS, Lees AM "Rhabdomyolysis from the coadministration of lovastatin and the antifungal agent itraconazole." N Engl J Med 333 (1995): 664-5. [PMID: 7637734]
77	Neuvonen PJ, Backman JT, Niemi M "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin." Clin Pharmacokinet 47 (2008): 463-74. [PMID: 18563955]
78	Neuvonen PJ, Jalava KM "Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid." Clin Pharmacol Ther 60 (1996): 54-61. [PMID: 8689812]
79	Stein CA, Goel S, Ghavamian R "Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatin therapy." Invest New Drugs 25 (2007): 277-8. [PMID: 17216557]
80	Watkins JL, Atkinson BJ, Pagliaro LC "Rhabdomyolysis in a prostate cancer patient taking ketoconazole and simvastatin: case report and review of the literature." Ann Pharmacother 45 (2011): e9. [PMID: 21304039]
81	Product Information. Pletal (cilostazol). Otsuka American Pharmaceuticals, Rockville, MD.
82	Suri A, Bramer SL "Effect of omeprazole on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 53-9. [PMID: 10702887]
83	Suri A, Forbes WP, Bramer SL "Effects of CYP3A inhibition on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 61-8. [PMID: 10702888]
84	Bedford TA, Rowbotham DJ "Cisapride: drug interactions of clinical significance." Drug Saf 15 (1996): 167-75. [PMID: 8879971]
85	Bran S, Murray WA, Hirsch IB, Palmer JP "Long QT syndrome during high-dose cisapride." Arch Intern Med 155 (1995): 765-8. [PMID: 7695465]
86	Desta Z, Soukhova N, Mahal SK, Flockhart DA "Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies." Drug Metab Dispos 28 (2000): 789-800. [PMID: 10859153]
87	Gray VS "Syncopal episodes associated with cisapride and concurrent drugs." Ann Pharmacother 32 (1998): 648-51. [PMID: 9640482]
88	Lewin MB, Bryant RM, Fenrich AL, Grifka RG "Cisapride-induced long QT interval." J Pediatr 128 (1996): 279-81. [PMID: 8636830]
89	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
90	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
91	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
92	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
93	Charles BG, Ravenscroft PJ, Rigby RJ "The ketoconazole-cyclosporin interaction in an elderly renal transplant patient." Aust N Z J Med 19 (1989): 292-3. [PMID: 2673179]
94	First MR, Schroeder TJ, Alexander JW, et al "Cyclosporine dose reduction by ketoconazole administration in renal transplant recipients." Transplantation 51 (1991): 365-70. [PMID: 1994529]
95	Gerntholtz T, Pascoe MD, Botha JF, Halkett J, Kahn D "The use of a cyclosporin-ketoconazole combination: making renal transplantation affordable in developing countries." Eur J Clin Pharmacol (2004):. [PMID: 15083250]
96	Horton CM, Freeman CD, Nolan PE Jr, Copeland JG 3rd "Cyclosporine interactions with miconazole and other azole- antimycotics: a case report and review of the literature." J Heart Lung Transplant 11 (1992): 1127-32. [PMID: 1457436]
97	Hwang WL, Gau JP, Young JH, Chia LG "Ketoconazole and high-dose methylprednisolone predisposing to cyclosporine-induced seizures: report of 3 cases." Acta Haematol 88 (1992): 139-41. [PMID: 1466196]
98	Keogh A, Spratt P, McCosker C, Macdonald, Mundy J, Kaan A "Ketoconazole to reduce the need for cyclosporine after cardiac transplantation." N Engl J Med 333 (1995): 628-33. [PMID: 7637723]
99	Kiss D, Thiel G "Glucose-intolerance and prolonged renal-transplant insufficiency due to ketoconazole-cyclosporin A interaction." Clin Nephrol 33 (1990): 207-8. [PMID: 2350909]
100	Kramer MR, Marshall SE, Denning DW, et al "Cyclosporine and itraconazole interaction in heart and lung transplant recipients." Ann Intern Med 113 (1990): 327-9. [PMID: 2165371]
101	Sobh M, Elagroudy A, Moustafa F, Harras F, Elbedewy M, Ghoneim M "Coadministration of ketoconazole to cyclosporin-treated kidney transplant recipients: a prospective randomized study." Am J Nephrol 15 (1995): 493-9. [PMID: 8546171]
102	Sorenson AL, Lovdahl M, Hewitt JM, et al. "Effects of ketoconazole on cyclosporine metabolism in renal allograft recipients." Transplant Proc 26 (1994): 2822. [PMID: 7940888]
103	Yee GC, McGuire TR "Pharmacokinetic drug interactions with cyclosporin (Part I)." Clin Pharmacokinet 19 (1990): 319-32. [PMID: 2208899]
104	Niwa T, Shiraga T, Takagi A "Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, CYP3A4 activities in human liver microsomes." Biol Pharm Bull 28 (2005): 1805-8. [PMID: 16141567]
105	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
106	Alderman CP, Allcroft PD "Digoxin-itraconazole interaction: possible mechanisms." Ann Pharmacother 31 (1997): 438-40. [PMID: 9101006]
107	Alderman CP, Jersmann HP "Digoxin-itraconazole interaction." Med J Aust 159 (1993): 838-9. [PMID: 8264497]
108	Balayssac D, Authier N, Cayre A, Coudore F "Does inhibition of P-glycoprotein lead to drug-drug interactions?" Toxicol Lett 156 (2005): 319-29. [PMID: 15763631]
109	Cone LA, Himelman RB, Hirschberg JN, Hutcheson JW "Itraconazole-related amaurosis and vomiting due to digoxin toxicity." West J Med 165 (1996): 322. [PMID: 8993214]
110	Drescher S, Glaeser H, Murdter T, Hitzl M, Eichelbaum M, Fromm MF "P-glycoprotein-mediated intestinal and biliary digoxin transport in humans." Clin Pharmacol Ther 73 (2003): 223-31. [PMID: 12621387]
111	Ito S, Koren G "Possible mechanism of digoxin-itraxonazole interaction." Ann Pharmacother 31 (1997): 1091-2. [PMID: 9296256]
112	Kauffman CA, Bagnasco FA "Digoxin toxicity associated with itraconazole therapy." Clin Infect Dis 15 (1992): 886-7. [PMID: 1332784]
113	Mathis AS, Friedman GS "Coadministration of digoxin with itraconazole in renal transplant recipients." Am J Kidney Dis 37 (2001): u101-8. [PMID: 11157404]
114	Mcclean KL, Sheehan GJ "Interaction between itraconazole and digoxin." Clin Infect Dis 18 (1994): 259-60. [PMID: 8161643]
115	Partanen J, Jalava KM, Neuvonen PJ "Itraconazole increases serum digoxin concentration." Pharmacol Toxicol 79 (1996): 274-6. [PMID: 8936563]
116	Rex J "Itraconazole-digoxin interaction." Ann Intern Med 116 (1992): 525. [PMID: 1310840]
117	Sachs MK, Blanchard LM, Green PJ "Interaction of itraconazole and digoxin." Clin Infect Dis 16 (1993): 400-3. [PMID: 8384010]
118	Ausband SC, Goodman PE "An unusual case of clarithromycin associated ergotism." J Emerg Med 4 (2001): 411-3. [PMID: 11728770]
119	Bird PA, Sturgess AD "Clinical ergotism with severe bilateral upper limb ischaemia precipitated by an erythromycin - ergotamine drug interaction." Aust N Z J Med 30 (2000): 635-6. [PMID: 11108077]
120	Blanche P, Rigolet A, Gombert B, Ginsburg C, Salmon D, Sicard D "Ergotism related to a single dose of ergotamine tartrate in an AIDS patient treated with ritonavir." Postgrad Med J 75 (1999): 546-7. [PMID: 10616689]
121	Caballero-Granado FJ, Viciana P, Cordero E, Gomez-Vera MJ, del Nozal M, Lopez-Cortes LF "Ergotism related to concurrent administration of ergotamine tartrate and ritonavir in an AIDS patient." Antimicrob Agents Chemother 41 (1997): 1207. [PMID: 9145904]
122	Eadie MJ "Clinically significant drug interactions with agents specific for migraine attacks." Cns Drugs 15 (2001): 105-18. [PMID: 11460889]
123	Francis H, Tyndall A, Webb J "Severe vascular spasm due to erythromycin-ergotamine interaction." Clin Rheumatol 3 (1984): 243-6. [PMID: 6236021]
124	Hayton AC "Precipitation of acute ergotism by triacetyloleandomycin." N Z Med J 69 (1969): 42. [PMID: 5304704]
125	Horowitz RS, Dart RC, Gomez HF "Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction." Arch Intern Med 156 (1996): 456-8. [PMID: 8607732]
126	Leroy F, Asseman P, Pruvost P, Adnet P, Lacroix D, Thery C "Dihydroergotamine-erythromycin-induced ergotism." Ann Intern Med 109 (1988): 249. [PMID: 3389610]
127	Liaudet L "Severe ergotism associated with interaction between ritonavir and ergotamine." BMJ 318 (1999): 771. [PMID: 10082701]
128	Liaudet L, Buclin T, Jaccard C, Eckert P "Severe ergotism associated with interaction between ritonavir and ergotamine." Br Med J 318 (1999): 771. [PMID: 10082701]
129	Matthews NT, Havill JH "Ergotism with therapeutic doses of ergotamine tartrate." N Z Med J 89 (1979): 476-7. [PMID: 314074]
130	Montero A, Giovannoni AG, Tvrde PL "Leg ischemia in a patient receiving ritonavir and ergotamine." Ann Intern Med 130 (1999): 329. [PMID: 10068398]
131	Mortier E, Pouchet J, Vinceneux P, Lalande M "Ergotism related to interaction between nelfinavir and ergotamine." Am J Med 110 (2001): 594. [PMID: 11347624]
132	Product Information. Cafergot (caffeine-ergotamine). Novartis Pharmaceuticals, East Hanover, NJ.
133	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
134	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
135	Rosenthal E, Sala F, Chichmanian RM, Batt M, Cassuto JP "Ergotism related to concurrent administration of ergotamine tartrate and indinavir." JAMA 281 (1999): 987. [PMID: 10086430]
136	Spiegel M, Schmidauer C, Kampfl A, Sarcletti M, Poewe W "Cerebral ergotism under treatment with ergotamine and ritonavir." Neurology 57 (2001): 743-4. [PMID: 11524501]
137	Srisuma S, Lavonas EJ, Wananukul W "Ergotism and factitious hypotension associated with interaction of ergotamine with CYP3A4 inhibitors." Clin Toxicol (Phila) (2014): 1-4. [PMID: 24978905]
138	Tribble MA, Gregg CR, Margolis DM, Amirkhan R, Smith JW "Fatal ergotism induced by an HIV protease inhibitor." Headache 42 (2002): 694-5. [PMID: 12482227]
139	Vila A, Mykietiuk A, Bonvehi P, Temporiti E, Uruena A, Herrera F "Clinical ergotism induced by ritonavir." Scand J Infect Dis 33 (2001): 788-9. [PMID: 11728055]
140	Ghali R, De Lean J, Douville Y, Noel HP, Labbe R "Erythromycin-associated ergotamine intoxication: arteriographic and electrophysiologic analysis of a rare cause of severe ischemia of the lower extremities and associated ischemic neuropathy." Ann Vasc Surg 7 (1993): 291-6. [PMID: 8391300]
141	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
142	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
143	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
144	Product Information. Inspra (eplerenone). Searle, Chicago, IL.
145	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
146	Ray WA, Murray KT, Meredith S, Narasimhulu SS, Hall K, Stein CM "Oral erythromycin and the risk of sudden death from cardiac causes." N Engl J Med 351 (2004): 1089-96. [PMID: 15356306]
147	Alderman CP, Gebauer MG, Gilbert AL, Condon JT "Possible interaction of zopiclone and nefazodone." Ann Pharmacother 35 (2001): 1378-80. [PMID: 11724087]
148	Becquemont L, Mouajjah S, Escaffre O, Beaune P, Funck-Bretano C, Jaillon P "Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism." Drug Metab Dispos 27 (1999): 1068-73. [PMID: 10460808]
149	Product Information. Imovane (zopiclone). Rhone-Poulenc Rorer Canada Inc, Laval, IN.
150	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
151	Jalava KM, Olkkola KT, Neuvonen PJ "Itraconazole greatly increases plasma concentrations and effects of felodipine." Clin Pharmacol Ther 61 (1997): 410-5. [PMID: 9129558]
152	Neuvonen PJ, Suhonen R "Itraconazole interacts with felodipine." J Am Acad Dermatol 33 (1995): 134-5. [PMID: 7601933]
153	Tailor SAN "Peripheral edema due to nifedipine-itraconazole interaction: a case report." Arch Dermatol 132 (1996): 1374. [PMID: 8607648]
154	Tailor SAN, Gupta AK, Walker SE, Shear NH "Peripheral edema due to nifedipine-itraconazole interaction: a case report." Arch Dermatol 132 (1996): 350-2. [PMID: 8607648]
155	Labroo RB, Paine MF, Thummel KE, Kharasch ED "Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implicaitons for interindividual variability in disposition, efficacy, and drug interactions." Drug Metab Dispos 25 (1997): 1072-80. [PMID: 9311623]
156	Product Information. Actiq (fentanyl). Abbott Pharmaceutical, Abbott Park, IL.
157	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
158	Tateishi T, Krivoruk Y, Ueng YF, Wood AJ, Guengerich FP, Wood M "Identification of human cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation." Anesth Analg 82 (1996): 167-72. [PMID: 8712396]
159	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
160	Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA "CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes." Br J Clin Pharmacol 57 (2004): 287-97. [PMID: 14998425]
161	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
162	Phansalker S, Desai AA, Bell D, et al "High-priority drug-drug interactions for use in electronic health records." J Am Med Inform Assoc 19 (2012): 735-43. [PMID: 22539083]
163	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
164	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
165	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
166	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
167	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
168	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
169	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
170	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
171	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
172	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
173	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
174	Vizcaychipi MP, Walker S, Palazzo M "Serotonin syndrome triggered by tramadol." Br J Anaesth 99 (2007): 919. [PMID: 18006535]
175	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
176	Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
177	Ho PC, Ghose K, Saville D, Wanwimolruk S "Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers." Eur J Clin Pharmacol 56 (2000): 693-8. [PMID: 11214778]
178	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
179	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
180	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
181	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
182	Bolland MJ, Bagg W, Thomas MG, Lucas JA, Ticehurst R, Black PN "Cushing's syndrome due to interaction between inhaled corticosteroids and itraconazole." Ann Pharmacother 38 (2004): 46-9. [PMID: 14742792]
183	Daveluy A, Raignoux C, Miremont-Salame G, et al. "Drug interactions between inhaled corticosteroids and enzymatic inhibitors." Eur J Clin Pharmacol (2009):. [PMID: 19399485]
184	De Wachter E, Malfroot A, De Schutter I, Vanbesien J, De Schepper J "Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450." J Calif Dent Assoc 2 (2003): 72-5. [PMID: 15463853]
185	De Wachter E, Vanbesien J, De Schutter I, Malfroot A, De Schepper J "Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide." Eur J Pediatr (2003):. [PMID: 12719971]
186	Edsbacker S, Andersson T "Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease." Clin Pharmacokinet 43 (2004): 803-21. [PMID: 15355126]
187	Jonsson G, Astrom A, Andersson P "Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver." Drug Metab Dispos 23 (1995): 137-42. [PMID: 7720517]
188	Kedem E, Shahar E, Hassoun G, Pollack S "Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient." J Asthma 47 (2010): 830-1. [PMID: 20653496]
189	Main KM, Skov M, Sillesen IB, et al. "Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient." Acta Paediatr 91 (2002): 1008-11. [PMID: 12412882]
190	Molimard M, Girodet PO, Pollet C, et al. "Inhaled corticosteroids and adrenal insufficiency: prevalence and clinical presentation." Drug Saf 31 (2008): 769-74. [PMID: 18707191]
191	Product Information. Entocort (budesonide). AstraZeneca Pharma Inc, Mississauga, ON.
192	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
193	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
194	Raaska K, Niemi M, Neuvonen M, Neuvonen PJ, Kivisto KT "Plasma concentrations of inhaled budesonide and its effects on plasma cortisol are increased by the cytochrome P4503A4 inhibitor itraconazole." Clin Pharmacol Ther 72 (2002): 362-369. [PMID: 12386638]
195	Skov M, Main KM, Sillesen IB, Muller J, Koch C, Lanng S "Iatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonide." Eur Respir J 20 (2002): 127-33. [PMID: 12166560]
196	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
197	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
198	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
199	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
200	Akdag I, Ersoy A, Kahvecioglu S, Gullulu M, Dilek K "Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure." J Nephrol 19 (2006): 515-7. [PMID: 17048210]
201	Boomershine KH "Colchicine-induced rhabdomyolysis." Ann Pharmacother 36 (2002): 824-6. [PMID: 11978160]
202	Caraco Y, Putterman C, Rahamimov R, Ben-Chetrit E "Acute colchicine intoxication: possible role of erythromycin administration." J Rheumatol 19 (1992): 494-6. [PMID: 1578471]
203	Cheng VC, Ho PL, Yuen KY "Two probable cases of serious drug interaction between clarithromycin and colchicine." South Med J 98 (2005): 811-3. [PMID: 16144178]
204	Cohen O, Locketz G, Hershko AY, Gorshtein A, Levy Y "Colchicine-clarithromycin-induced rhabdomyolysis in Familial Mediterranean Fever patients under treatment for Helicobacter pylori." Rheumatol Int (2015):. [PMID: 26210999]
205	Colchicine: serious interactions. Prescrire Int 17 (2008): 151-3. [PMID: 19492485]
206	Dogukan A, Oymak FS, Taskapan H, Guven M, Tokgoz B, Utas C "Acute fatal colchicine intoxication in a patient on continuous ambulatory peritoneal dialysis (CAPD). Possible role of clarithromycin administration." Clin Nephrol 55 (2001): 181-2. [PMID: 11269688]
207	Hung IF, Wu AK, Cheng VC, et al. "Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study." Clin Infect Dis 41 (2005): 291-300. [PMID: 16007523]
208	McKinnell J, Tayek JA "Short term treatment with clarithromycin resulting in colchicine-induced rhabdomyolysis." J Clin Rheumatol 15 (2009): 303-5. [PMID: 19734738]
209	Product Information. Biaxin (clarithromycin). Abbott Pharmaceutical, Abbott Park, IL.
210	Product Information. Colcrys (colchicine). AR Scientific Inc, Philadelphia, PA.
211	Putterman C, Ben-Chetrit E, Caraco Y, Levy M "Colchicine intoxication: clinical pharmacology, risk factors, features, and management." Semin Arthritis Rheum 21 (1991): 143-55. [PMID: 1788551]
212	Rollot F, Pajot O, Chauvelot-Moachon L, Nazal EM, Kelaidi C, Blanche P "Acute colchicine intoxication during clarithromycin administration." Ann Pharmacother 38 (2004): 2074-7. [PMID: 15494379]
213	Schiff D, Drislane FW "Rapid-onset colchicine myoneuropathy." Arthritis Rheum 35 (1992): 1535-6. [PMID: 1472131]
214	Severe colchicine-macrolide interactions. Prescrire Int 12 (2003): 18-9. [PMID: 12602385]
215	Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ "Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation." Biochem Pharmacol 53 (1996): 111-6. [PMID: 8960070]
216	van der Velden W, Huussen J, Ter Laak H, de Sevaux R "Colchicine-induced neuromyopathy in a patient with chronic renal failure: the role of clarithromycin." Neth J Med 66 (2008): 204-6. [PMID: 18490798]
217	Wilbur K, Makowsky M "Colchicine myotoxicity: case reports and literature review." Pharmacotherapy 24 (2004): 1784-92. [PMID: 15585444]
218	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
219	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
220	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
221	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
222	Product Information. Emflaza (deflazacort). Marathon Pharmaceuticals, Deerfield, IL.
223	Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91. [PMID: 6779990]
224	Engels FK, Mathot RA, Loos WJ, van Schaik RH, Verweij J "Influence of high-dose ketoconazole on the pharmacokinetics of docetaxel." Cancer Biol Ther 5 (2006): 833-9. [PMID: 16775418]
225	McInnes GT, Brodie MJ "Drug interactions that matter: a critical reappraisal." Drugs 36 (1988): 83-110. [PMID: 3063497]
226	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
227	Starr SP, Hammann F, Gotta V, et al. "Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity." Br J Clin Pharmacol 450 (2016): 22-27. [PMID: 27868228]
228	Vodovar D, Arnaout M, Mongardon N, et al. "Severe docetaxel overdose induced by pharmacokinetic interaction with dronedarone." J Clin Oncol 29 (2011): e694-5. [PMID: 21730272]
229	Yong WP, Wang LZ, Tham LS, et al. "A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers." Cancer Chemother Pharmacol 62 (2008): 243-51. [PMID: 17909805]
230	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
231	Product Information. Prezcobix (cobicistat-darunavir). Janssen Pharmaceuticals, Titusville, NJ.
232	Product Information. Slynd (drospirenone). Exeltis USA, Inc., Chatham, NJ.
233	Product Information. Symtuza (cobicistat/darunavir/emtricitabine/tenof). Janssen Pharmaceuticals, Titusville, NJ.
234	Product Information. Yasmin (drospirenone-ethinyl estradiol) Berlex Laboratories, Richmond, CA.
235	Mendell J, Zahir H, Matsushima N, et al. "Drug-Drug Interaction Studies of Cardiovascular Drugs Involving P-Glycoprotein, an Efflux Transporter, on the Pharmacokinetics of Edoxaban, an Oral Factor Xa Inhibitor." Am J Cardiovasc Drugs (2013):. [PMID: 23784266]
236	Parasrampuria DA, Mendell J, Shi M, Matsushima N, Zahir H, Truitt K "Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine." Br J Clin Pharmacol 0 (2016): epub. [PMID: 27530188]
237	Product Information. Savaysa (edoxaban). Daiichi Sankyo, Inc., Parsippany, NJ.
238	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
239	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
240	Han TH, Gopal AK, Ramchandren R, et al. "CYP3A-mediated drug-drug interaction potential and excretion of brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive hematologic malignancies." J Clin Pharmacol 53 (2013): 866-77. [PMID: 23754575]
241	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
242	Product Information. Padcev (enfortumab vedotin). Seattle Genetics Inc, Bothell, WA.
243	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
244	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
245	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
246	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
247	Arrington-Sanders R, Hutton N, Siberry GK "Ritonavir-fluticasone interaction causing Cushing syndrome in HIV-infected children and adolescents." Pediatr Infect Dis J 25 (2006): 1044-1048. [PMID: 17072128]
248	Bhumbra NA, Sahloff EG, Oehrtman SJ, Horner JM "Exogenous Cushing syndrome with inhaled fluticasone in a child receiving lopinavir/ritonavir." Ann Pharmacother 41 (2007): 1306-9. [PMID: 17535841]
249	Boorsma M, Andersson N, Larsson P, Ullman A "Assessment of the relative systemic potency of inihaled fluticasone and budesonide." Eur Respir J 9 (1996): 1427-32. [PMID: 8836654]
250	Brus R "Effects of high-dose inhaled corticosteroids on plasma cortisol consentrations in healthy adults." Arch Intern Med 159 (1999): 1903-8. [PMID: 10493320]
251	Fardon TC, Lee DK, Haggart K, McFarlane LC, Lipworth BJ "Adrenal suppression with dry powder formulations of fluticasone propionate and mometasone furoate." Am J Respir Crit Care Med 170 (2004): 960-6. [PMID: 15184207]
252	Foisy MM, Yakiwchuk EM, Chiu I, Singh AE "Adrenal suppression and Cushing's syndrome secondary to an interaction between ritonavir and fluticasone: a review of the literature." HIV Med 9 (2008): 389-96. [PMID: 18459946]
253	Gillett MJ, Cameron PU, Nguyen HV, Hurley DM, Mallal SA "Iatrogenic Cushing's syndrome in an HIV-infected patient treated with ritonavir and inhaled fluticasone." AIDS 19 (2005): 740-1. [PMID: 15821405]
254	Grahnen A, Eckernas SA, Brundin RM, Ling-Andersson A "An assessment of the systemic activity of single doses of inhaled fluticasone propionate in healthy volunteers." Br J Clin Pharmacol 38 (1994): 521-5. [PMID: 7888290]
255	Gupta SK, Dube MP "Exogenous Cushing syndrome mimicking human immunodeficiency virus lipodystrophy." Clin Infect Dis 35 (2002): E69-71. [PMID: 12203188]
256	Hillebrand-Haverkort ME, Prummel MF, ten Veen JH "Ritonavir-induced Cushing's syndrome in a patient treated with nasal fluticasone." AIDS 13 (1999): 1803. [PMID: 10509596]
257	Jinno S, Goshima C "Progression of Kaposi sarcoma associated with iatrogenic Cushing syndrome in a person with HIV/AIDS." AIDS Read 18 (2008): 100-4. [PMID: 18333287]
258	Johnson SR, Marion AA, Vrchoticky T, Emmanuel PJ, Lujan-Zilbermann J "Cushing syndrome with secondary adrenal insufficiency from concomitant therapy with ritonavir and fluticasone." J Pediatr 148 (2006): 386-388. [PMID: 16615973]
259	Kelly HW "Comparison of inhaled corticosteroids." Ann Pharmacother 32 (1998): 220-32. [PMID: 9496409]
260	Li AM "Ritonavir and fluticasone: Beware of this potentially fatal combination." J Pediatr 148 (2006): 294-5. [PMID: 16615953]
261	Lipworth BJ "Systemic adverse effects of inhaled corticosteroid therapy - A systematic review and meta-analysis." Arch Intern Med 159 (1999): 941-55. [PMID: 10326936]
262	Naef R, Schmid C, Hofer M, Minder S, Speich R, Boehler A "Itraconazole comedication increases systemic levels of inhaled fluticasone in lung transplant recipients." Respiration 74 (2007): 418-22. [PMID: 17003527]
263	Nocent C, Raherison C, Dupon M, Taytard A "Unexpected effects of inhaled fluticasone in an HIV patient with asthma." J Asthma 41 (2004): 793-5. [PMID: 15641628]
264	Parmar JS, Howell T, Kelly J, Bilton D "Profound adrenal suppression secondary to treatment with low dose inhaled steroids and itraconazole in allergic bronchopulmonary aspergillosis in cystic fibrosis." Thorax 57 (2002): 749-50. [PMID: 12149540]
265	Pearce RE, Leeder JS, Kearns GL "Biotransformation of fluticasone: in vitro characterization." Drug Metab Dispos 34 (2006): 1035-40. [PMID: 16565171]
266	Pessanha TM, Campos JM, Barros AC, Pone MV, Garrido JR, Pone SM "Iatrogenic Cushing's syndrome in a adolescent with AIDSs on ritonavir and inhaled fluticasone. case report and literature review." AIDS 21 (2007): 529-32. [PMID: 17301576]
267	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
268	Product Information. Flonase (fluticasone). Glaxo Wellcome, Research Triangle Park, NC.
269	Product Information. Flovent (fluticasone). Glaxo Wellcome, Research Triangle Park, NC.
270	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
271	Product Information. Veramyst (fluticasone nasal). GlaxoSmithKline, Research Triangle Park, NC.
272	Rouanet I, Peyriere H, Mauboussin JM, Vincent D "Cushing's syndrome in a patient treated by ritonavir/lopinavir and inhaled fluticasone." HIV Med 4 (2003): 149-50. [PMID: 12702137]
273	Sastre J "Pharmacology of fluticasone propionate." J Investig Allergol Clin Immunol 7 (1997): 382-4. [PMID: 9416555]
274	Schmid C, Naef R, Speich R, Boehler A "Addition of inhaled fluticasone propionate to systemic immunosuppression after lung transplantation: Cushing's Syndrome in patients on itraconazole comedication." Transplantation 76 (2003): 263-4. [PMID: 12865822]
275	Soldatos G, Sztal-Mazer S, Woolley I, Stockigt J "Exogenous glucocorticoid excess as a result of ritonavir-fluticasone interaction." Intern Med J 35 (2005): 67-8. [PMID: 15667475]
276	Todd GR, Acerini CL, Ross-Russell, Zahra S, Warner JT, McCance D "Survey of adrenal crisis associated witwh inhaled corticosteroids in the United Kingdom." Arch Dis Child 87 (2002): 457-61. [PMID: 12456538]
277	Vassiliadi D, Tsagarakis S "Unusual causes of Cushing's syndrome." Arq Bras Endocrinol Metabol 51 (2007): 1245-52. [PMID: 18209862]
278	Woods DR, Arun CS, Corris PA, Perros P "Cushing's syndrome without excess cortisol." BMJ 332 (2006): 469-70. [PMID: 16497762]
279	Bernecker C, West TB, Mansmann G, Scherbaum WA, Willenberg HS "Hypercortisolism caused by ritonavir associated inhibition of CYP 3A4 under inhalative glucocorticoid therapy. 2 case reports and a review of the literature." Exp Clin Endocrinol Diabetes 120 (2012): 125-7. [PMID: 22328106]
280	Kempsford R, Norris V, Siederer S "Vilanterol trifenatate, a novel inhaled long-acting beta2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD." Pulm Pharmacol Ther 26 (2013): 256-64. [PMID: 23232038]
281	Lonnebo A, Grahnen A, Jansson B, Brundin RM, Lingandersson A, Eckernas SA "An assessment of the systemic effects of single and repeated doses of inhaled fluticasone propionate and inhaled budesonide in healthy volunteers." Eur J Clin Pharmacol 49 (1996): 459-63. [PMID: 8706770]
282	Samaras K, Pett S, Gowers A, McMurchie M, Cooper DA "Iatrogenic Cushing's syndrome with osteoporosis and secondary adrenal failure in HIV-infected patients receiving inhaled corticosteroids and ritonavir-boosted protease inhibitors: six cases." J Clin Endocrinol Metab 90 (2005): 4394-8. [PMID: 15755851]
283	Valin N, De Castro N, Garrait V, Bergeron A, Bouche C, Molina JM "Iatrogenic Cushing's syndrome in HIV-infected patients receiving ritonavir and inhaled fluticasone: description of 4 new cases and review of the literature." J Int Assoc Physicians AIDS Care 8 (2009): 113-21. [PMID: 19270151]
284	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
285	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
286	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
287	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
288	Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7. [PMID: 11298069]
289	Baune B, Flinois JP, Furlan V, et al. "Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5." J Pharm Pharmacol 51 (1999): 419-26. [PMID: 10385214]
290	Charbit B, Becquemont L, Lepere B, Peytavin G, Funck-Bretano C "Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine." Clin Pharmacol Ther 72 (2002): 514-23. [PMID: 12426515]
291	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
292	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
293	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
294	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
295	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
296	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
297	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
298	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
299	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
300	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
301	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
302	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
303	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
304	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
305	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
306	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
307	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
308	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
309	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
310	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
311	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
312	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
313	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
314	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
315	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
316	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
317	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
318	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
319	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
320	Abbas R, Hug BA, Leister C, Burns J, Sonnichsen D "Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects." Br J Clin Pharmacol 71 (2011): 522-7. [PMID: 21395644]
321	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
322	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
323	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
324	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
325	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
326	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
327	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
328	Hamberg P, Woo MM, Chen LC, et al. "Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor." Cancer Chemother Pharmacol 68 (2011): 805-13. [PMID: 21706316]
329	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
330	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
331	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
332	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
333	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
334	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
335	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
336	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
337	DeVane CL, Nemeroff CB "Clinical pharmacokinetics of quetiapine - An atypical antipsychotic." Clin Pharmacokinet 40 (2001): 509-22. [PMID: 11510628]
338	Geraci MJ, McCoy SL, Crum PM, Patel RA "Antipsychotic-induced priapism in an HIV patient: a cytochrome P450-mediated drug interaction." Int J Emerg Med 3 (2010): 81-4. [PMID: 20606815]
339	Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB "Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics." Br J Clin Pharmacol 61 (2006): 58-69. [PMID: 16390352]
340	Hantson P, Di Fazio V, Wallemacq P "Toxicokinetic interaction between quetiapine and antiretroviral therapy following quetiapine overdose." Drug Metab Lett 4 (2010): 7-8. [PMID: 20201782]
341	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
342	Spina E, de Leon J "Metabolic drug interactions with newer antipsychotics: a comparative review." Basic Clin Pharmacol Toxicol 100 (2007): 4-22. [PMID: 17214606]
343	Spina E, Scordo MG, D'Arrigo C "Metabolic drug interactions with new psychotropic agents." Fundam Clin Pharmacol 17 (2003): 517-38. [PMID: 14703714]
344	Urichuk L, Prior TI, Dursun S, Baker G "Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions." Curr Drug Metab 9 (2008): 410-8. [PMID: 18537577]
345	Schulz-Du Bois C, Schulz-Du Bois AC, Bewig B, et al. "Major increase of quetiapine steady-state plasma concentration following co-administration of clarithromycin: confirmation of the pharmacokinetic interaction potential of quetiapine." Pharmacopsychiatry 41 (2008): 258-9. [PMID: 19067264]
346	Product Information. Orgovyx (relugolix). Myovant Sciences, Inc., Brisbane, CA.
347	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
348	Abadie-Kemmerly S, Pankey GA, Dalvisio JR "Failure of ketoconazole treatment of blastomyces dermatidis due to interaction of isoniazid and rifampin." Ann Intern Med 109 (1988): 844-5. [PMID: 3190036]
349	Blomley M, Teare E, De Belder A, et al "Itraconazole and anti-tuberculosis drugs." Lancet 336 (1990): 1255. [PMID: 1978097]
350	Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6. [PMID: 1558427]
351	Brass C, Galgiani JN, Blaschke TF, et al "Disposition of ketoconazole, an oral antifungal, in humans." Antimicrob Agents Chemother 21 (1982): 151-8. [PMID: 6282204]
352	Doble N, Shaw R, Rowland-Hill C, et al "Pharmacokinetic study of the interaction between rifampicin and ketoconazole." J Antimicrob Chemother 21 (1988): 633-5. [PMID: 3391862]
353	Drayton J, Dickinson G, Rinaldi MG "Coadministration of rifampin and itraconazole leads to undetectable levels of serum itraconazole." Clin Infect Dis 18 (1994): 266. [PMID: 8161649]
354	Engelhard D, Stutman HR, Marks MI "Interaction of ketoconazole with rifampin and isoniazid." N Engl J Med 311 (1984): 1681-3. [PMID: 6095080]
355	Jaruratanasirikul S, Sriwiriyajan S "Effect of rifampicin on the pharmacokinetics of itraconazole in normal volunteers and AIDS patients." Eur J Clin Pharmacol 54 (1998): 155-8. [PMID: 9626920]
356	Lefort A, Launay O, Carbon C "Uveitis associated with rifabutin prophylaxis and itraconazole therapy." Ann Intern Med 125 (1996): 939-40. [PMID: 8967681]
357	Meunier F "Serum fungistatic and fungicidal activity in volunteers receiving antifungal agents." Eur J Clin Microbiol 5 (1986): 103-9. [PMID: 3516681]
358	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online.".
359	Schaferkorting M "Pharmacokinetic optimisation of oral antifungal therapy." Clin Pharmacokinet 25 (1993): 329-41. [PMID: 8261715]
360	Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8. [PMID: 9385296]
361	Tucker RM, Denning DW, Hanson LH, et al "Interaction of azoles with rifampin, phenytoin, and carbamazepine: in vitro and clinical observations." Clin Infect Dis 14 (1992): 165-74. [PMID: 1315160]
362	Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65. [PMID: 1559307]
363	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
364	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
365	Product Information. Evotaz (atazanavir-cobicistat). Bristol-Myers Squibb, Princeton, NJ.
366	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
367	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
368	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
369	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
370	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
371	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
372	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
373	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
374	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
375	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
376	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
377	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
378	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
379	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
380	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
381	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
382	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
383	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
384	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
385	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
386	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
387	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
388	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
389	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
390	Kim KA, Chung J, Jung DH, Park JY "Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes." Eur J Clin Pharmacol 60 (2004): 575-81. [PMID: 15365656]
391	Niemi M, Tornio A, Pasanen MK, Fredrikson H, Neuvonen PJ, Backman JT "Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide." Eur J Clin Pharmacol 62 (2006): 463-72. [PMID: 16758263]
392	Product Information. Imodium (loperamide). Janssen Pharmaceutica, Titusville, NJ.
393	Tayrouz Y, Ganssmann B, Ding R, et al. "Ritonavir increases loperamide plasma concentrations without evidence for P-glycoprotein involvement." Clin Pharmacol Ther 70 (2001): 405-14. [PMID: 11719726]
394	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
395	Holtzman CW, Wiggins BS, Spinler SA "Role of P-glycoprotein in statin drug interactions." Pharmacotherapy 26 (2006): 1601-7. [PMID: 17064205]
396	NoorZurani MH, Vicknasingam B, Narayanan S "Itraconazole-induced torsade de pointes in a patient receiving methadone substitution therapy." Drug Alcohol Rev 28 (2009): 688-90. [PMID: 19930027]
397	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
398	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
399	Glynn AM, Slaughter RL, Brass C, et al "Effects of ketoconazole on methylprednisolone pharmacokinetics and cortisol secretion." Clin Pharmacol Ther 39 (1986): 654-9. [PMID: 3709030]
400	Kandrotas RJ, Slaughter RL, Brass C, Jusko WJ "Ketoconazole effects on methylprednisolone disposition and their joint suppression of endogenous cortisol." Clin Pharmacol Ther 42 (1987): 465-70. [PMID: 3311551]
401	Kotlyar M, Brewer ER, Golding M, Carson SW "Nefazodone inhibits methylprednisolone disposition and enhances its adrenal-suppressant effect." J Clin Psychopharmacol 23 (2003): 652-6. [PMID: 14624194]
402	LaForce CF, Szefler SJ, Miller MF, Ebling W, Brenner M "Inhibition of methylprednisolone elimination in the presence of erythromycin therapy." J Allergy Clin Immunol 72 (1983): 34-9. [PMID: 6602160]
403	Varis T, Backman JT, Kivisto KT, Neuvonen PJ "Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone." Clin Pharmacol Ther 67 (2000): 215-21. [PMID: 10741623]
404	Varis T, Kaukonen KM, Kivisto KT, Neuvonen PJ "Plasma concentrations and effects of oral methylprednisolone are considerably increased by itraconazole." Clin Pharmacol Ther 64 (1998): 363-8. [PMID: 9797792]
405	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
406	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
407	Product Information. Nimotop (nimodipine). Bayer, West Haven, CT.
408	Heinig R, Adelmann HG, Ahr G "The effect of ketoconazole on the pharmacokinetics, pharmacodynamics and safety of nisoldipine." Eur J Clin Pharmacol 55 (1999): 57-60. [PMID: 10206086]
409	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
410	Desta Z, Kerbusch T, Flockhart DA "Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)." Clin Pharmacol Ther 65 (1999): 10-20. [PMID: 9951426]
411	Flockhart DA, Drici MD, Kerbusch T, et al "Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with tourette syndrome." J Clin Psychopharmacol 20 (2000): 317-24. [PMID: 10831018]
412	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
413	Krahenbuhl S, Sauter B, Kupferschmidt H, Krause M, Wyss PA, Meier PJ "Case report: reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication." Am J Med Sci 309 (1995): 315-6. [PMID: 7771501]
414	Mangum EM, Graham KK "Lopinavir-Ritonavir: a new protease inhibitor." Pharmacotherapy 21 (2001): 1352-63. [PMID: 11714208]
415	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
416	Damkier P, Hansen LL, Brosen K "Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine." Br J Clin Pharmacol 48 (1999): 829-38. [PMID: 10594487]
417	Holford NH, Coates PE, Guentert TW, Riegelman S, Sheiner LB "The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration--effect relationships." Br J Clin Pharmacol 11 (1981): 187-95. [PMID: 7213522]
418	Katz HI "Drug interactions of the newer oral antifungal agents." Br J Dermatol 141 (1999): 26-32. [PMID: 10730911]
419	Kaukonen KM, Olkkola KT, Neuvonen PJ "Itraconazole increases plasma concentrations of quinidine." Clin Pharmacol Ther 62 (1997): 510-7. [PMID: 9390107]
420	Laakso M, Aberg A, Savola J, Pentikainen PJ, Pyorala K "Diseases and drugs causing prolongation of the QT interval." Am J Cardiol 59 (1987): 862-5. [PMID: 3825950]
421	McNulty RM, Lazor JA, Sketch M "Transient increase in plasma quinidine concentrations during ketoconazole-quinidine therapy." Clin Pharm 8 (1989): 222-5. [PMID: 2706896]
422	Product Information. Quiniglute (quinidine). Berlex, Richmond, CA.
423	Raehl CL, Patel AK, LeRoy M "Drug-induced torsade de pointes." Clin Pharm 4 (1985): 675-90. [PMID: 2416504]
424	Roden DM, Woosley RL, Primm RK "Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care." Am Heart J 111 (1986): 1088-93. [PMID: 3716982]
425	Stanek EJ, Simko RJ, DeNofrio D, Pavri BB "Prolonged quinidine half-life with associated toxicity in a patient with hepatic failure." Pharmacotherapy 17 (1997): 622-5. [PMID: 9165569]
426	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
427	Khaliq Y, Gallicano K, Venance S, Kravcik S, Cameron DW "Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and cerebrospinal fluid from patients infected with human immunodeficiency virus." Clin Pharmacol Ther 68 (2000): 637-46. [PMID: 11180024]
428	Crommentuyn KM, Mulder JW, Sparidans RW, Huitema AD, Schellens JH, Beijnen JH "Drug-Drug Interaction between Itraconazole and the Antiretroviral Drug Lopinavir/Ritonavir in an HIV-1-Infected Patient with Disseminated Histoplasmosis." Clin Infect Dis 38 (2004): E73-5. [PMID: 15095234]
429	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
430	Hall MCS, Ahmad S "Interaction between sildenafil and HIV-1 combination therapy." Lancet 353 (1999): 2071-2. [PMID: 10376645]
431	Hyland R, Roe GH, Jones BC, Smith DA "Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil." Br J Clin Pharmaacol 51 (2001): 239-48. [PMID: 11298070]
432	Merry C, Barry MG, Ryan M, Tjia JF, Hennessy M, Eagling VA, Mulcahy F, Back DJ "Interaction of sildenafil and indinavir when co-administered to HIV-positive patients." AIDS 13 (1999): f101-7. [PMID: 10546851]
433	Muirhead GJ, Wulff MB, Fielding A, Kleinermans D, Buss N "Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir." Br J Clin Pharmacol 50 (2000): 99-107. [PMID: 10930961]
434	Nandwani R, Gourlay Y "Possible interaction between sildenafil and HIV combination therapy." Lancet 353 (1999): 840. [PMID: 10459981]
435	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
436	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
437	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
438	Claesson K, Brattstrom C, Burke JT "Sirolimus and erythromycin interaction: two cases." Transplant Proc 33 (2001): 2136. [PMID: 11377477]
439	Dodds-Ashley E "Management of drug and food interactions with azole antifungal agents in transplant recipients." Pharmacotherapy 30 (2010): 842-54. [PMID: 20653361]
440	Floren LC, Christians U, Zimmerman JJ, et al "Sirolimus oral bioavailability increases ten-fold with concomitant ketoconazole." Clin Pharmacol Ther 65 (1999): 159.
441	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
442	Albengres E, Le Louet H, Tillement JP "Systemic antifungal agents. Drug interactions of clinical significance." Drug Saf 18 (1998): 83-97. [PMID: 9512916]
443	Assan R, Fredj G, Larger E, Feutren G, Bismuth H "FK 506/fluconazole interaction enhances FK 506 nephrotoxicity." Diabete Metab 20 (1994): 49-52. [PMID: 7520007]
444	Billaud EM, Guillemain R, Tacco F, Chevalier P "Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients." Br J Clin Pharmacol 46 (1998): 271-4. [PMID: 9764970]
445	Cakaloglu Y, Tredger JM, Devlin J, Williams R "Importance of cytochrome p-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients." Hepatology 20 (1994): 309-16. [PMID: 7519161]
446	Capone D, Gentile A, Imperatore P, Palmiero G, Basile V "Effects of itraconazole on tacrolimus blood concentrations in a renal transplant recipient." Ann Pharmacother 33 (1999): 1124-5. [PMID: 10534229]
447	Floren LC, Bekersky I, Benet LZ, et al. "Tacrolimus oral bioavailability doubles with coadministration of ketoconazole." Clin Pharmacol Ther 62 (1997): 41-9. [PMID: 9246018]
448	Katari SR, Magnone M, Shapiro R, et al "Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients." Clin Transplant 11 (1997): 237-42. [PMID: 9193849]
449	Macias MO, Salvador P, Hurtado JL, Martin I "Tacrolimus-itraconazole interaction in a kidney transplant patient." Ann Pharmacother 34 (2000): 536. [PMID: 10772445]
450	Manez R, Martin M, Raman V, et al. "Fluconazole therapy in transplant recipients receiving FK506." Transplantation 57 (1994): 1521-3. [PMID: 7515201]
451	Mieles L, Venkataramanan R, Yokoyama I, Warty VJ, Starzl TE "Interaction between FK506 and clotrimazole in a liver transplant recipient." Transplantation 52 (1991): 1086-7. [PMID: 1721250]
452	Moreno M, Latorre A, Manzanares C, et al "Clinical management of tacrolimus drug interactions in renal transplant patients." Transplant Proc 31 (1999): 2252-3. [PMID: 10500564]
453	Osowski CL, Dix SP, Lin LS, Mullins RE, Geller RB, Wingard JR "Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients." Transplantation 61 (1996): 1268-72. [PMID: 8610430]
454	Pai MP, Allen S "Voriconazole inhibition of tacrolimus metabolism." Clin Infect Dis 36 (2003): 1089-91. [PMID: 12684931]
455	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
456	Soltero L, Carbajal H, Rodriguez-Montalvo C, Valdes A "Coadministration of tacrolimus and ketoconazole in renal transplant recipients: cost analysis and review of metabolic effects." Transplant Proc 35 (2003): 1319-21. [PMID: 12826147]
457	Vasquez EM, Pollak R, Benedetti E "Clotrimazole increases tacrolimus blood levels: a drug interaction in kidney transplant patients." Clin Transplant 15 (2001): 95-9. [PMID: 11264634]
458	Venkataramanan R, Zang S, Gayowski T, Singh N "Voriconazole inhibition of the metabolism of tacrolimus in a liver transplant recipient and in human liver microsomes." Antimicrob Agents Chemother 46 (2002): 3091-3. [PMID: 12183280]
459	Franco-Salinas G, de la Rosette JJ, Michel MC "Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations." Clin Pharmacokinet 49 (2010): 177-88. [PMID: 20170206]
460	Kamimura H, Oishi S, Matsushima H, et al. "Identification of cytochrome P450 isozymes involved in metabolism of the alpha1-adrenoceptor blocker tamsulosin in human liver microsomes." Xenobiotica 28 (1998): 909-22. [PMID: 9849639]
461	Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT.
462	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
463	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
464	Cantilena LR Jr, Ferguson CL, Monahan BP "Torsades de pointes occurring in association with terfenadine use." JAMA 266 (1991): 2376. [PMID: 1977935]
465	Crane JK, Shih HT "Syncope and cardiac arrhythmia due to an interaction between itraconazole and terfenadine." Am J Med 95 (1993): 445-6. [PMID: 8213879]
466	Honig PK, Wortham DC, Zamani K, Conner DP, Mullin JC, Cantilena LR. Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences [published correction appears in JAMA 1993 Apr 28;269(16):2088]. JAMA. 1993;269(12):1513-1518. [PMID: 8445813]
467	Honig PK, Worham DC, Zamani K, Mullin JC, Conner DP, Cantilena LR "The effect of fluconazole on the steady-state pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine in humans." Clin Pharmacol Ther 53 (1993): 630-6. [PMID: 8513654]
468	Honig PK, Wortham DC, Hull R, Zamani K, Smith JE, Cantilena LR "Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics." J Clin Pharmacol 33 (1993): 1201-6. [PMID: 8126255]
469	Honig PK, Wortham DC, Zamani K, et al "Terfenadine-ketoconazole interaction: pharmacokinetic and electrocardiographic consequences." JAMA 269 (1993): 1513-8. [PMID: 8445813]
470	June RA, Nasr I "Torsades de pointes with terfenadine ingestion." Am J Emerg Med 15 (1997): 542-3. [PMID: 9270401]
471	Jurima-Romet M, Crawford K, Cyr T, Inaba T "Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals." Drug Metab Dispos 22 (1994): 849-57. [PMID: 7895601]
472	Kivisto KT, Neuvonen PJ, Klotz U "Inhibition of terfenadine metabolism - pharmacokinetic and pharmacodynamic consequences." Clin Pharmacokinet 27 (1994): 1-5. [PMID: 7955768]
473	Mathews DR, McNutt B, Okerholm R, et al "Torsades de pointes occurring in association with terfenadine use." JAMA 266 (1991): 2375-6. [PMID: 1920744]
474	Monahan BP, Ferguson CL, Killeavy ES, et al "Torsades de pointes occurring in association with terfenadine use." JAMA 264 (1990): 2788-90. [PMID: 1977935]
475	Pohjola-Sintonen S, Viitasalo M, Toivonene L, Neuvonen P "Torsades de pointes after terfenadine-itraconazole interaction." BMJ 306 (1993): 186. [PMID: 8382980]
476	Product Information. Seldane (terfenadine). Hoechst Marion-Roussel Inc, Kansas City, MO.
477	Woosley RL, Chen Y, Freiman JP, Gillis RA "Mechanism of the cardiotoxic actions of terfenadine." JAMA 269 (1993): 1532-6. [PMID: 8445816]
478	Zimmermann M, Duruz H, Guinand O, et al "Torsades de Pointes after treatment with terfenadine and ketoconazole." Eur Heart J 13 (1992): 1002-3. [PMID: 1644069]
479	Vonmoltke LL, Greenblatt DJ, Duan SX, Harmatz JS, Wright CE, Shader RI "Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo." J Clin Psychopharmacol 16 (1996): 104-12. [PMID: 8690825]
480	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
481	Adamson PC "Pharmacokinetics of all-trans-retinoic acid: clinical implications in acute promyelocytic leukemia." Semin Hematol 31 (1994): 14-7. [PMID: 7831580]
482	Cordoba R, Ramirez E, Lei SH, et al. "Hypercalcemia due to an interaction of all-trans retinoic acid (ATRA) and itraconazole therapy for acute promyelocytic leukemia successfully treated with zoledronic acid." Eur J Clin Pharmacol 64 (2008): 1031-2. [PMID: 18584165]
483	Dixon KS, Hassoun A "Pseudotumor cerebri due to the potentiation of all-trans retinoic acid by voriconazole." J Am Pharm Assoc (2003) 50 (2010): 742-4. [PMID: 21071321]
484	Hameed DA, el-Metwally TH "The effectiveness of retinoic acid treatment in bladder cancer: impact on recurrence, survival and TGFalpha and VEGF as end-point biomarkers." Cancer Biol Ther 7 (2008): 92-100. [PMID: 18347417]
485	Kizaki M, Ueno H, Yamazoe Y, et al "Mechanisms of retinoid resistance in leukemic cells: possible role of cytochrome P450 and P-glycoprotein." Blood 87 (1996): 725-33. [PMID: 8555497]
486	Lotan Y, Lotan R "Prevention of bladder cancer recurrence by retinoic acid-ketoconazole: a promising strategy?" Cancer Biol Ther 7 (2008): 101-2. [PMID: 18347420]
487	Marill J, Cresteil T, Lanotte M, Chabot GG "Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites." Mol Pharmacol 58 (2000): 1341-8. [PMID: 11093772]
488	Moresco G, Martinello F, Souza LC "[Acute renal failure in patient treated with ATRA and amphotericin B: case report]." J Bras Nefrol 33 (2011): 276-81. [PMID: 21789447]
489	Muindi JRF, Young CW, Warrell RP "Clinical pharmacology of all-trans retinoic acid." Leukemia 8 (1994): 1807-12. [PMID: 7967726]
490	Product Information. Vesanoid (tretinoin). Roche Laboratories, Nutley, NJ.
491	Rigas JR, Francis PA, Muindi JR, Kris MG, Huselton C, DeGrazia F, Orazem JP, Young CW, Warrell RP Jr "Constitutive variability in the pharmacokinetics of the natural retinoid, all-trans-retinoic acid, and its modulation by ketoconazole." J Natl Cancer Inst 85 (1993): 1921-6. [PMID: 8230282]
492	Albert NE, Kazi S, Santoro J, Dougherty R "Ritonavir and Epidural Triamcinolone as a Cause of Iatrogenic Cushing's Syndrome." Am J Med Sci (2012):. [PMID: 22543594]
493	Dort K, Padia S, Wispelwey B, Moore CC "Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report." AIDS Res Ther 6 (2009): 10. [PMID: 19505306]
494	Fessler D, Beach J, Keel J, Stead W "Iatrogenic hypercortisolism complicating triamcinolone acetonide injections in patients with HIV on ritonavir-boosted protease inhibitors." Pain Physician 15 (2012): 489-93. [PMID: 23159966]
495	Hagan JB, Erickson D, Singh RJ "Triamcinolone Acetonide Induced Secondary Adrenal Insufficiency Related to Impaired CYP3A4 Metabolism by Coadministration of Nefazodone." Pain Med (2010):. [PMID: 20456080]
496	Hall JJ, Hughes CA, Foisy MM, Houston S, Shafran S "Iatrogenic Cushing syndrome after intra-articular triamcinolone in a patient receiving ritonavir boosted darunavir." Int J STD AIDS (2013):. [PMID: 23970582]
497	Levine D, Ananthakrishnan S, Garg A "Iatrogenic Cushing syndrome after a single intramuscular corticosteroid injection and concomitant protease inhibitor therapy." J Am Acad Dermatol 65 (2011): 877-8. [PMID: 21920248]
498	McConkey HZ, Williams H, Kulasegaram R, Graham E "Orbital floor triamcinolone causing Cushing's syndrome in a patient treated with Kaletra for HIV 1." BMJ Case Rep 2013 (2013):. [PMID: 23440982]
499	Sadarangani S, Berg ML, Mauck W, Rizza S "Iatrogenic Cushing Syndrome Secondary to Ritonavir-Epidural Triamcinolone Interaction: An Illustrative Case and Review." Interdiscip Perspect Infect Dis 2014 (2014): 849432. [PMID: 24895495]
500	Schwarze-Zander C, Klingmuller D, Klumper J, Strassburg CP, Rockstroh JK "Triamcinolone and ritonavir leading to drug-induced Cushing syndrome and adrenal suppression: description of a new case and review of the literature." Infection (2013):. [PMID: 23873267]
501	Grierson MJ, Harrast MA "Iatrogenic Cushing Syndrome After Epidural Steroid Injections for Lumbar Radiculopathy in an HIV-Infected Patient Treated With Ritonavir: A Case Report Highlighting Drug Interactions for Spine Interventionalists." PM R 4 (2012): 234-7. [PMID: 22443962]
502	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
503	Antoniou T, Tseng AL "Interactions between antiretrovirals and antineoplastic drug therapy." Clin Pharmacokinet 44 (2005): 111-145. [PMID: 15656694]
504	Ariffin H, Omar KZ, Ang EL, Shekhar K "Severe vincristine neurotoxicity with concomitant use of itraconazole." J Paediatr Child Health 39 (2003): 638-9. [PMID: 14629538]
505	Bashir H, Motl S, Metzger ML, et al. "Itraconazole-enhanced chemotherapy toxicity in a patient with Hodgkin lymphoma." J Pediatr Hematol Oncol 28 (2006): 33-35. [PMID: 16394890]
506	Bermudez M, Fuster JL, Llinares E, Galera A, Gonzalez C "Itraconazole-related increased vincristine neurotoxicity: case report and review of literature." J Pediatr Hematol Oncol 27 (2005): 389-392. [PMID: 16012330]
507	Bohme A, Ganser A, Hoelzer D "Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL." Ann Hematol 71 (1995): 311-2. [PMID: 8534764]
508	Bosque E "Possible drug interaction between itraconazole and vinorelbine tartrate leading to death after one dose of chemotherapy." Ann Intern Med 134 (2001): 427. [PMID: 11242511]
509	Carrion C, Espinosa E, Herrero A, Garcia B "Possible vincristine-isoniazid interaction." Ann Pharmacother 29 (1995): 201. [PMID: 7756727]
510	Chan JD "Pharmacokinetic drug interactions of vinca alkaloids: summary of case reports." Pharmacotherapy 18 (1998): 1304-7. [PMID: 9855331]
511	Chen S, Wu D, Sun A, et al "Itraconazole-enhanced vindesine neurotoxicity in adult acute lymphoblastic leukaemia." Am J Hematol 82 (2007): 942. [PMID: 17617780]
512	Corona G, Vaccher E, Spina M, Toffoli G "Potential hazard drug-drug interaction between boosted protease inhibitors and vinblastine in HIV patients with Hodgkin's lymphoma." AIDS 27 (2013): 1033-5. [PMID: 23698067]
513	Eiden C, Palenzuela G, Hillaire-Buys D, et al. "Posaconazole-increased vincristine neurotoxicity in a child: a case report." J Pediatr Hematol Oncol 31 (2009): 292-5. [PMID: 19346885]
514	Fedeli L, Colozza M, Boschetti E, et al. "Pharmacokinetics of vincristine in cancer patients treated with nifedipine." Cancer 64 (1989): 1805-11. [PMID: 2790693]
515	Gillies J, Hung KA, Fitzsimons E, Soutar R "Severe vincristine toxicity in combination with itraconazole." Clin Lab Haematol 20 (1998): 123-4. [PMID: 9681224]
516	Haddad A, Davis M, Lagman R "The pharmacological importance of cytochrome CYP3A4 in the palliation of symptoms: review and recommendations for avoiding adverse drug interactions." Support Care Cancer 15 (2007): 251-7. [PMID: 17139496]
517	Harnicar S, Adel N, Jurcic J "Modification of vincristine dosing during concomitant azole therapy in adult acute lymphoblastic leukemia patients." J Oncol Pharm Pract 15 (2009): 175-82. [PMID: 19282418]
518	Jain S, Kapoor G "Severe life threatening neurotoxicity in a child with acute lymphoblastic leukemia receiving posaconazole and vincristine." Pediatr Blood Cancer 54 (2010): 783. [PMID: 20205256]
519	Jeng MR, Feusner J "Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia." Pediatr Hematol Oncol 18 (2001): 137-42. [PMID: 11255732]
520	Kajita J, Kuwabara T, Kobayashi H, Kobayashi S "CYP3A4 is mainly responsibile for the metabolism of a new vinca alkaloid, vinorelbine, in human liver microsomes." Drug Metab Dispos 28 (2000): 1121-7. [PMID: 10950859]
521	Kamaluddin M, McNally P, Breatnach F, et al "Potentiation of vincristine toxicity by itraconazole in children with lymphoid malignancies." Acta Paediatr 90 (2001): 1204-7. [PMID: 11697438]
522	Kivisto KT, Kroemer HK, Eichelbaum M "The role of human cytochrome p450 enzymes in the metabolism of anticancer agents: implications for drug interactions." Br J Clin Pharmacol 40 (1995): 523-30. [PMID: 8703657]
523	Kotb R, Vincent I, Dulioust A, et al. "Life-threatening interaction between antiretroviral therapy and vinblastine in HIV-associated multicentric Castleman's disease." Eur J Haematol 76 (2006): 269-71. [PMID: 16451402]
524	Leveque D, Santucci R, Pavillet J, Herbrecht R, Bergerat JP "Paralytic ileus possibly associated with interaction between ritonavir/lopinavir and vincristine." Pharm World Sci 31 (2009): 619-21. [PMID: 19757141]
525	Mantadakis E, Amoiridis G, Kondi A, Kalmanti M "Possible increase of the neurotoxicity of vincristine by the concurrent use of posaconazole in a young adult with leukemia." J Pediatr Hematol Oncol 29 (2007): 130. [PMID: 17279013]
526	Moriyama B, Falade-Nwulia O, Leung J, et al. "Prolonged half-life of voriconazole in a CYP2C19 homozygous poor metabolizer receiving vincristine chemotherapy: avoiding a serious adverse drug interaction." Mycoses 54 (2011): e877-9. [PMID: 21615537]
527	Murphy JA, Ross LM, Gibson BE "Vincristine toxicity in five children with acute lymphoblastic leukaemia." Lancet 346 (1995): 443. [PMID: 7623589]
528	Porter CC, Carver AE, Albano EA "Vincristine induced peripheral neuropathy potentiated by voriconazole in a patient with previously undiagnosed CMT1X." Pediatr Blood Cancer 52 (2009): 298-300. [PMID: 18837430]
529	Product Information. Oncovin (vincristine). Lilly, Eli and Company, Indianapolis, IN.
530	Product Information. Velban (vinblastine). Lilly, Eli and Company, Indianapolis, IN.
531	Sathiapalan RK, Al-Nasser A, El-Solh H, Al-Mohsen I, Al-Jumaah S "Vincristine-itraconazole interaction: cause for increasing concern." J Pediatr Hematol Oncol 24 (2002): 591. [PMID: 12368705]
532	Sathiapalan RK, El-Solh H "Enhanced vincristine neurotoxicity from drug interactions: case report and review of literature." Pediatr Hematol Oncol 18 (2001): 543-6. [PMID: 11764105]
533	Takahashi N, Kameoka Y, Yamanaka Y, et al. "Itraconazole oral solution enhanced vincristine neurotoxicity in five patients with malignant lymphoma." Intern Med 47 (2008): 651-3. [PMID: 18379154]
534	Tobe SW, Siu LL, Jamal SA, Skorecki KL, Murphy GF, Warner E "Vinblastine and erythromycin: an unrecognized serious drug interaction." Cancer Chemother Pharmacol 35 (1995): 188-90. [PMID: 7805175]
535	Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y "Potentiation of vincristine and adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors." Cancer Res 43 (1983): 2267-72. [PMID: 6831450]
536	van Schie RM, Bruggemann RJ, Hoogerbrugge PM, Te Loo DM "Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukaemia." J Antimicrob Chemother 66 (2011): 1853-6. [PMID: 21652620]
537	Yano R, Tani D, Watanabe K, et al. "Evaluation of potential interaction between vinorelbine and clarithromycin." Ann Pharmacother 43 (2009): 453-8. [PMID: 19261952]
538	Zhou XJ, Zhou-Pan XR, Gauthier T, Placidi M, Maurel P, Rahmani R "Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation. Metabolic drug interactions." Biochem Pharmacol 45 (1993): 853-61. [PMID: 8452560]
539	Zhou-Pan XR, Seree E, Zhou XJ, et al "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res 53 (1993): 5121-6. [PMID: 8221648]
540	Auclair B, Berning SE, Huitt GA, Peloquin CP "Potential interaction between itraconazole and clarithromycin." Pharmacotherapy 19 (1999): 1439-44. [PMID: 10600094]
541	Chiba M, Hensleigh M, Nishime JA, Balani SK, Lin JH "Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor." Drug Metab Dispos 24 (1996): 307-14. [PMID: 8820421]
542	Lukkari E, Juhakoski A, Aranko K, Neuvonen PJ "Itraconazole moderately increases serum concentrations of oxybutynin but does not affect those of the active metabolite." Eur J Clin Pharmacol 52 (1997): 403-6. [PMID: 9272412]
543	Product Information. Axert (almotriptan) Pharmacia and Upjohn, Kalamazoo, MI.
544	Product Information. Lotronex (alosetron). Glaxo Wellcome, Research Triangle Park, NC.
545	Dorsey ST, Biblio LA "Prolonged QT interval and torsades de pointes caused by the combination of fluconazole and amitriptyline." Am J Emerg Med 18 (2000): 227-9. [PMID: 10750939]
546	Gannon RH "Fluconazole-nortriptyline drug interaction." Ann Pharmacother 26 (1992): 1456. [PMID: 1477454]
547	Newberry DL, Bass SN, Mbanefo CO "A fluconazole/amitriptyline drug interaction in three male adults." Clin Infect Dis 24 (1997): 270-1. [PMID: 9114163]
548	Robinson RF, Nahata MC, Olshefski RS "Syncope associated with concurrent amitriptyline and fluconazole therapy." Ann Pharmacother 34 (2000): 1406-9. [PMID: 11144697]
549	Spina E, Avenoso A, Campo GM, Scordo MG, Caputi AP, Perucca E "Effect of ketoconazole on the pharmacokinetics of imipramine and desipramine in healthy subjects." Br J Clin Pharmacol 43 (1997): 315-8. [PMID: 9088587]
550	Polk RE, Crouch MA, Israel DS, et al. "Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men." Pharmacotherapy 19 (1999): 1378-84. [PMID: 10600086]
551	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
552	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
553	Daneshmend TK, Warnock DW "Clinical pharmacokinetics of ketoconazole." Clin Pharmacokinet 14 (1988): 13-34. [PMID: 3280211]
554	Product Information. Coumadin (warfarin). DuPont Pharmaceuticals, Wilmington, DE.
555	Smith AG "Potentiation of oral anticoagulants by ketoconazole." Br Med J 288 (1984): 188-9. [PMID: 6318877]
556	Visser LE, Penning-Van Beest FJ, Kasbergen AA, et al. "Overanticoagulation associated with combined use of antifungal agents and coumarin anticoagulants." Clin Pharmacol Ther 71 (2002): 496-502. [PMID: 12087353]
557	Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83. [PMID: 7944078]
558	Yeh J, Soo S, Summerton C, Richardson C "Potentiation of action of warfarin by itraconazole." Br Med J 301 (1990): 669. [PMID: 2171705]
559	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
560	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
561	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
562	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
563	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
564	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
565	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
566	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
567	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
568	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
569	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
570	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
571	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
572	Busse KH, Formentini E, Alfaro RM, Kovacs JA, Penzak SR "Influence of antiretroviral drugs on the pharmacokinetics of prednisolone in HIV-infected individuals." J Acquir Immune Defic Syndr 48 (2008): 561-6. [PMID: 18645517]
573	Couturier J, Steele M, Hussey L, Pawliuk G "Steroid-induced mania in an adolescent: risk factors and management." Can J Clin Pharmacol 8 (2001): 109-12. [PMID: 11493940]
574	Finkenbine RD, Frye MD "Case of psychosis due to prednisone-clarithromycin interaction." Gen Hosp Psychiat 20 (1998): 325-6. [PMID: 9788033]
575	Garey KW, Rubinstein I, Gotfried MH, Khan IJ, Varma S, Danziger LH "Long-term clarithromycin decreases prednisone requirements in elderly patients with prednisone-dependent asthma." Chest 118 (2000): 1826-7. [PMID: 11115481]
576	Itkin IH, Menzel ML "The use of macrolide antibiotic substances in the treatment of asthma." J Allergy Clin Immunol 45 (1970): 146-62. [PMID: 5309312]
577	Lebrun-Vignes B, Archer VC, Diquest B, et al. "Effect of itraconazole on the pharmacokinetics of prednisolone and methylprednisolone and cortisol secretion in healthy subjects." Br J Clin Pharmacol 51 (2001): 443-50. [PMID: 11422002]
578	Penzak SR, Formentini E, Alfaro RM, Long M, Natarajan V, Kovacs J "Prednisolone pharmacokinetics in the presence and absence of ritonavir after oral prednisone administration to healthy volunteers." J Acquir Immune Defic Syndr 40 (2005): 573-80. [PMID: 16284534]
579	Ulrich B, Frey FJ, Speck RF, Frey BM "Pharmacokinetics/pharmacodynamics of ketoconazole-prednisolone interaction." J Pharmacol Exp Ther 260 (1992): 487-90. [PMID: 1738098]
580	Varis T, Kivisto KT, Neuvonen PJ "The effect of itraconazole on the pharmacokinetics and pharmacodynamics of oral prednisolone." Eur J Clin Pharmacol 56 (2000): 57-60. [PMID: 10853878]
581	Yamashita SK, Ludwig EA, Middleton E Jr, Jusko WJ "Lack of pharmacokinetic and pharmacodynamic interactions between ketoconazole and prednisolone." Clin Pharmacol Ther 49 (1991): 558-70. [PMID: 1827622]
582	Zurcher RM, Frey BM, Frey FJ "Impact of ketoconazole on the metabolism of prednisolone." Clin Pharmacol Ther 45 (1989): 366-72. [PMID: 2639662]
583	Pekol T, Daniels JS, Labutti J, et al "Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites." Drug Metab Dispos 33 (2005): 771-7. [PMID: 15764713]
584	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
585	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
586	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
587	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
588	Spina E, Arena D, Scordo MG, Fazio A, Pisani F, Perucca E "Elevation of plasma carbamazepine concentrations by ketoconazole in patients with epilepsy." Ther Drug Monit 19 (1997): 535-8. [PMID: 9357097]
589	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
590	Blum RA, D'Andrea DT, Florentino BM, et al "Increased gastric pH and the bioavailability of fluconazole and ketoconazole." Ann Intern Med 114 (1991): 755-7. [PMID: 2012358]
591	Lazar JD, Wilner KD "Drug interactions with fluconazole." Rev Infect Dis 12 Suppl 3 (1990): s327-33. [PMID: 2330488]
592	Product Information. Sensipar (cinacalcet). Amgen USA, Thousand Oaks, CA.
593	Sriwiriyajan S, Samaeng M, Ridtitid W, Mahatthanatrakul W, Wongnawa M "Pharmacokinetic interactions between ciprofloxacin and itraconazole in healthy male volunteers." Biopharm Drug Dispos 32 (2011): 168-74. [PMID: 21360715]
594	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
595	Devenport MH, Crook D, Wynn V, Lees LJ "Metabolic effects of low-dose fluconazole in healthy female users and non-users of oral contraceptives." Br J Clin Pharmacol 27 (1989): 851-9. [PMID: 2547410]
596	Pillans PI, Sparrow MJ "Pregnancy associated with a combined oral contraceptive and itraconazole." N Z Med J 106 (1993): 436. [PMID: 8414287]
597	Sinofsky FE, Pasquale SA "The effect of fluconazole on circulating ethinyl estradiol levels in women taking oral contraceptives." Am J Obstet Gynecol 178 (1998): 300-4. [PMID: 9500490]
598	Weisberg E "Interactions between oral contraceptives and antifungals antibacterials - Is contraceptive failure the result?." Clin Pharmacokinet 36 (1999): 309-13. [PMID: 10384856]
599	Multum Information Services, Inc. Expert Review Panel.
600	Product Information. Cerubidine (daunorubicin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
601	Product Information. Daunoxome (daunorubicin liposomal). Nexstar Pharmaceuticals Inc, Boulder, CO.
602	Product Information. Idamycin (idarubicin). Pharmacia and Upjohn, Kalamazoo, MI.
603	Ahonen J, Olkkola KT, Neuvonen PJ "The effect of the antimycotic itraconazole on the pharmacokinetics and pharmacodynamics of diazepam." Fundam Clin Pharmacol 10 (1996): 314-8. [PMID: 8836707]
604	Andersson T, Miners JO, Veronese ME, Birkett DJ "Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms." Br J Clin Pharmacol 38(2) (1994): 131-7. [PMID: 7981013]
605	Product Information. Valium (diazepam). Roche Laboratories, Nutley, NJ.
606	May DB, Drew RH, Yedinak KC, Bartlett JA "Effect of simultaneous didanosine administration on itraconazole absorption in healthy volunteers." Pharmacotherapy 14 (1994): 509-13. [PMID: 7997384]
607	Moreno F, Hardin TC, Rimaldi MG, Graybill JR "Itraconazole-didanosine excipient interaction." JAMA 269 (1993): 1508. [PMID: 8383255]
608	Product Information. Cardura (doxazosin). Pfizer US Pharmaceuticals, New York, NY.
609	Lemma GL, Desta Z, Jones DR, Gorski JC, Hall SD "Droperidol is predominantly metabolized by human CYP3A enzymes." Clin Pharmacol Ther 73 (2003): 16.
610	Product Information. Droperidol (droperidol). Abbott Pharmaceutical, Abbott Park, IL.
611	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
612	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
613	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
614	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
615	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
616	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
617	Bottiger Y, Tybring G, Gotharson E, Bertilsson L "Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin." Clin Pharmacol Ther 62 (1997): 384-91. [PMID: 9357389]
618	Carlson JA, Mann HJ, Canafax DM "Effect of pH on disintegration and dissolution of ketoconazole tablets." Am J Hosp Pharm 40 (1983): 1334-6. [PMID: 6310994]
619	Chin TWF, Loeb M, Fong IW "Effects of an acidic beverage (coca-cola) on absorption of ketoconazole." Antimicrob Agents Chemother 39 (1995): 1671-5. [PMID: 7486898]
620	Jaruratanasirikul S, Sriwiriyajan S "Effect of omeprazole on the pharmacokinetics of itraconazole." Eur J Clin Pharmacol 54 (1998): 159-61. [PMID: 9626921]
621	Piscitelli SC, Goss TF, Wilton JH, D'Andrea DT, Goldstein H, Schentag JJ "Effects of ranitidine and sucralfate on ketoconazole bioavailability." Antimicrob Agents Chemother 35 (1991): 1765-71. [PMID: 1952845]
622	Product Information. Aciphex (rabeprazole) Janssen Pharmaceuticals, Titusville, NJ.
623	Product Information. Kapidex (dexlansoprazole). Takeda Pharmaceuticals America, Lincolnshire, IL.
624	Product Information. Nexium (esomeprazole) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
625	Product Information. Prevacid (lansoprazole). TAP Pharmaceuticals Inc, Deerfield, IL.
626	Product Information. Prilosec (omeprazole). Merck & Co, Inc, West Point, PA.
627	Product Information. Protonix (pantoprazole) Wyeth-Ayerst Laboratories, Philadelphia, PA.
628	Van der Meer JW, Keuning JJ "The influence of gastric acidity on the bio-availability of ketoconazole." J Antimicrob Chemother 6 (1980): 552-4. [PMID: 6253434]
629	Product Information. Dilantin (phenytoin). Parke-Davis, Morris Plains, NJ.
630	Damkier P, Hansen LL, Brosen K "Effect of fluvoxamine on the pharmacokinetics of quinidine." Eur J Clin Pharmacol 55 (1999): 451-6. [PMID: 10492058]
631	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
632	Product Information. Reminyl (galantamine) Janssen Pharmaceuticals, Titusville, NJ.
633	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
634	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
635	Yasui N, Kondo T, Otani K, Furukori H, Mihara K, Suzuki A, Kaneko S, Inoue Y "Effects of itraconazole on the steady-state plasma concentrations of haloperidol and its reduced metabolite in schizophrenic patients: In vivo evidence of the involvement of CYP3A4 for haloperidol metabolism." J Clin Psychopharmacol 19 (1999): 149-54. [PMID: 10211916]
636	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
637	Product Information. Crixivan (indinavir). Merck & Co, Inc, West Point, PA.
638	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
639	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
640	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
641	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
642	Product Information. Nizoral (ketoconazole). Janssen Pharmaceutica, Titusville, NJ.
643	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
644	Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
645	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
646	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
647	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
648	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
649	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
650	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
651	Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
652	Product Information. Alvesco (ciclesonide). Nycomed USA, Florham Park, NJ.
653	Product Information. Omnaris (ciclesonide nasal). Sepracor Inc, Marlborough, MA.
654	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
655	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
656	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
657	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
658	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
659	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
660	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
661	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
662	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
663	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
664	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
665	Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
666	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
667	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
668	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
669	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
670	Product Information. Vimpat (lacosamide). UCB Pharma Inc, Smyrna, GA.
671	Product Information. Fosrenol (lanthanum carbonate). Shire US Inc, Florence, KY.
672	Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
673	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
674	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
675	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
676	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
677	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
678	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
679	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
680	Bun SS, Ciccolini J, Bun H, Aubert C, Catalin J "Drug interactions of paclitaxel metabolism in human liver microsomes." J Chemother 15 (2003): 266-74. [PMID: 12868554]
681	Jamis-Dow CA, Klecker RW, Katki AG, Collins JM "Metabolism of Taxol by human liver microsomes and effect of inhibitors (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 34 (1993): a21981993.
682	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
683	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
684	Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
685	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
686	Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
687	Product Information. Rythmol SR (propafenone). GlaxoSmithKline, Research Triangle Park, NC.
688	Botsch S, Gautier JC, Beaune P, Eichelbaum M, Kroemer HK "Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites." Mol Pharmacol 43 (1993): 120-6. [PMID: 8423765]
689	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
690	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
691	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
692	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
693	Product Information. Banzel (rufinamide). Eisai Inc, Teaneck, NJ.
694	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
695	Product Information. Lokelma (sodium zirconium cyclosilicate). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
696	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
697	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
698	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
699	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
700	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
701	Product Information. Kadcyla (ado-trastuzumab). Genentech, South San Francisco, CA.
702	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
703	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
704	Zeng Z, Andrew NW, Arison BH, Luffer-Atlas D, Wang RW "Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes." Xenobiotica 28 (1998): 313-21. [PMID: 9574819]
705	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
706	Product Information. Sporanox oral solution (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
707	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
708	Okubo M, Murayama N, Miura J, Chiba Y, Yamazaki H "Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients." Biochem Pharmacol 93 (2015): 104-9. [PMID: 25475885]
709	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
710	Sitsen JM, Maris FA, Timmer CJ "Concomitant use of mirtazapine and cimetidine: a drug-drug interaction study in healthy male subjects." Eur J Clin Pharmacol 56 (2000): 389-94. [PMID: 11009047]
711	Stormer E, von Moltke LL, Shader RI, Greenblatt DJ "Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4" Drug Metab Dispos 28 (2000): 1168-75. [PMID: 10997935]
712	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
713	Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
714	Rosche J, Froscher W, Abendroth D, Liebel J "Possible oxcarbazepine interaction with cyclosporine serum levels: A single case study." Clin Neuropharmacol 24 (2001): 113-6. [PMID: 11307049]
715	Zaccara G, Gangemi PF, Bendoni L, Menge GP, Schwabe S, Monza GC "Influence of single and repeated doses of oxcarbazepine on the pharmacokinetic profile of felodipine." Ther Drug Monit 15 (1993): 39-42. [PMID: 8451779]
716	Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
717	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
718	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
719	Mirghani RA, Ericsson O, Tybring G, Gustafsson LL, Bertilsson L "Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man." Eur J Clin Pharmacol 59 (2003): 23-8. [PMID: 12743670]
720	Mirghani RA, Hellgren U, Bertilsson L, Gustafsson LL, Ericsson O "Metabolism and elimination of quinine in healthy volunteers." Eur J Clin Pharmacol (2003):. [PMID: 12920491]
721	Mirghani RA, Hellgren U, Westerberg PA, Ericsson O, Bertilsson L, Gustafsson LL "The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo." Clin Pharmacol Ther 66 (1999): 454-60. [PMID: 10579472]
722	Mirghani RA, Yasar U, Zheng T, et al "Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway." Drug Metab Dispos 30 (2002): 1368-71. [PMID: 12433805]
723	Product Information. Qualaquin (quinine). AR Scientific Inc, Philadelphia, PA.
724	Wanwimolruk S, Paine MF, Pusek SN, Watkins PB "Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?" Br J Clin Pharmacol 54 (2002): 643-51. [PMID: 12492613]
725	Zhang H, Coville PF, Walker RJ, Miners JO, Birkett DJ, Wanwimolruk S "Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine." Br J Clin Pharmacol 43 (1997): 245-52. [PMID: 9088578]
726	Zhao XJ, Ishizaki T "A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (K-i) and type of inhibition." Eur J Drug Metab Pharm 24 (1999): 272-8. [PMID: 10716067]
727	Zhao XJ, Ishizaki T "Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes." Br J Clin Pharmacol 44 (1997): 505-11. [PMID: 9384469]
728	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
729	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
730	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
731	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
732	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
733	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
734	Brynne N, Forslund C, Hallen B, Gustafsson LL, Bertilsson L "Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity." Br J Clin Pharmacol 48 (1999): 564-72. [PMID: 10583027]
735	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
736	Dattilo PB, Nordin C "Prolonged QT associated with an overdose of trazodone." J Clin Psychiatry 68 (2007): 1309-10. [PMID: 17854263]
737	Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
738	Greenblatt DJ, von Moltke LL, Harmatz JS, et al. "Short-term exposure to low-dose ritonavir impairs clearance and enhances adverse effects of trazodone." J Clin Pharmacol 43 (2003): 414-22. [PMID: 12723462]
739	Levenson JL "Prolonged QT interval after trazodone overdose." Am J Psychiatry 156 (1999): 969-70. [PMID: 10360146]
740	Mazur A, Strasberg B, Kusniec J, Sclarovsky S "QT prolongation and polymorphous ventricular tachycardia associated with trasodone-amiodarone combination." Int J Cardiol 52 (1995): 27-9. [PMID: 8707432]
741	Product Information. Desyrel (trazodone). Bristol-Myers Squibb, Princeton, NJ.
742	Product Information. Oleptro (traZODone). Labopharm Inc, Laval, AL.
743	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
744	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
745	Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ.
746	Farkas D, Volak L, Harmatz J, von Moltke L, Court M, Greenblatt D "Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem." Clin Pharmacol Ther 85 (2009): 644-50. [PMID: 19242403]
747	Greenblatt DJ, von Moltke LL, Harmatz JS, et al. "Differential impairment of triazolam and zolpidem clearance by ritonavir." J Acquir Immune Defic Syndr 24 (2000): 129-36. [PMID: 10935688]
748	Greenblatt DJ, vonMoltke LL, Harmatz JS, Mertzanis P, Graf JA, Durol ALB, Counihan M, RothSchechter B, Shader RI "Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole." Clin Pharmacol Ther 64 (1998): 661-71. [PMID: 9871431]
749	Luurila H, Kivisto KT, Neuvonen PJ "Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem." Eur J Clin Pharmacol 54 (1998): 163-6. [PMID: 9626922]
750	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
751	Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT "Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects." Br J Clin Pharmacol 63 (2007): 116-20. [PMID: 16822278]
752	Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
753	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
754	Saag MS, Powderly WG, Cloud GA, et al "Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis." N Engl J Med 326 (1992): 83-9
755	Product Information. Fungizone (amphotericin B). Apothecon Inc, Plainsboro, NJ.
756	Product Information. Ambisome (amphotericin B liposomal) Nexstar Pharmaceuticals, San Dimas, CA.
757	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
758	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
759	Product Information. Allegra (fexofenadine). Hoechst Marion-Roussel Inc, Kansas City, MO.
760	Product Information. Allegra-D (fexofenadine-pseudoephedrine). Chattem Consumer Products, Chattanooga, TN.
761	Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
762	Product Information. Letairis (ambrisentan). Gilead Sciences, Foster City, CA.
763	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
764	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
765	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
766	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
767	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
768	Product Information. Xerava (eravacycline). Tetraphase Pharmaceuticals, Inc, Watertown, MA.
769	Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
770	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
771	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
772	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
773	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
774	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
775	Martin P, Oliver S, Robertson J, Kennedy SJ, Read J, Duvauchelle T "Pharmacokinetic drug interactions with vandetanib during cadministration with rifampicin or itraconazole." Drugs R D 11 (2011): 37-51. [PMID: 21410294]
776	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
777	Product Information. Claritin (loratadine). Schering Laboratories, Kenilworth, NJ.
778	Woosley R, Carrow WR "Analysis of potential adverse drug reactions--a case of mistaken identity." Am J Cardiol 74 (1994): 208-9. [PMID: 8023797]
779	Yumibe N, Huie K, Chen KJ, Clement RP, Cayen MN "Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine." Int Arch Allery Immunol 207 (1995): 420. [PMID: 7613198]
780	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
781	Ekstrom G, Gunnarsson UB "Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes." Drug Metab Dispos 24 (1996): 955-61. [PMID: 8886604]
782	Halldin MM, Bredberg E, Angelin B, Arvidsson T, Askemark Y, Elofsson S, Widman M "Metabolism and excretion of ropivacaine in humans." Drug Metab Dispos 24 (1996): 962-8. [PMID: 8886605]
783	Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT "The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine." Anesth Analg 91 (2000): 1207-12. [PMID: 11049910]
784	McClure JH "Ropivacaine." Br J Anaesth 76 (1996): 300-7. [PMID: 8777115]
785	Oda Y, Furuichi K, Tanaka K, Hiroi T, Imaoka S, Asada A, Fujimori M, Funae Y "Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450." Anesthesiology 82 (1995): 214-20. [PMID: 7832304]
786	Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
787	Arlander E, Ekstrom G, Alm C, Carrillo JA, Bielenstein M, Bottiger Y, Bertilsson L, Gustafsson LL "Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors." Clin Pharmacol Ther 64 (1998): 484-91. [PMID: 9834040]
788	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
789	Miceli JJ, Smith M, Robarge L, Morse T, Laurent A "The effects of ketoconazole on ziprasidone pharmacokinetics--a placebo-controlled crossover study in healthy volunteers." Br J Clin Pharmacol 49(suppl 1) (2000): s71-6. [PMID: 10771458]
790	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
791	Wilner KD, Hansen RA, Folger CJ, Geoffroy P "The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid." Br J Clin Pharmacol 49(Suppl 1) (2000): 57S-60S. [PMID: 10771455]
792	Prakash C, Kamel A, Cui D, Whalen RD, Miceli JJ, Tweedie D "Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions." Br J Clin Pharmacol 49(Suppl 1) (2000): 35S-42S. [PMID: 10771452]

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