Drug General Information (ID: DDI0VMEZ6S)
Drug Name			Meloxicam		Drug Info		Itraconazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Nsaids/Analgesics				Antifungal Agents
Structure

Mechanism of Meloxicam-Itraconazole Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Meloxicam				Itraconazole
Mechanism		Meloxicam				Decrease therapeutic effects of meloxicam
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Meloxicam when combined with Itraconazole

Recommended Action
Management		Caution and monitoring of pharmacologic response to meloxicam is recommended whenever itraconazole is added to or withdrawn from therapy, and the meloxicam dosage adjusted as necessary.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
3	Product Information. Sporanox oral solution (itraconazole). Janssen Pharmaceutica, Titusville, NJ.