Details of Drug

Details of Drug

 Drug General Information (ID: D0848)
  Drug Name
Iron Dextran
  Drug Type Small molecule
  Drug Synonymous
Chinofer; Dexferrum; Dextrofer; Eisendextran; Fenate; Ferridextran; Ferrodextran; Ferroglucin; Hematran; Icar; Imfergen; Imferon; Imperon; Imposil; Infed; Norferan; Polyfer; Proferdex; Prolongal; Ursoferran; Dextran iron complex; Eisendextran [German]; Fero Gradumet; Ferric dextran; Iron dextran complex; Iron dextran injection; Iron hydrogenated dextran; Ironorm injection; B 75; Dextrofer 75; Ferdex 100; Ferroglukin 75; Myofer 100; A 100 (Pharmaceutical); American Regent Brand of Iron-Dextran Complex; Dextran-Iron Complex; Fe-Dextran; GlaxoSmithKline Brand of Iron-Dextran Complex; Goldline Brand of Iron-Dextran Complex; Hauck Brand of Iron-Dextran Complex; Hawthron Brand of Iron-Dextran Complex; Iro-Jex; Iron-dextran complex; Sanofi Brand of Iron-Dextran Complex; Sulfuric acid, iron salt; Sulphuric acid, iron salt; Vortech Brand of Iron-Dextran Complex; Watson Brand of Iron-Dextran Complex; Sulfuric acid iron salt (1:1); Sulfuric acid, iron salt (1:); Sulfuric acid iron(2+) salt (1:1)
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  Disease Class 3A00: Iron deficiency anaemia
  Therapeutic Class Iron Supplement
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula FeH2O4S
  InChI 1S/Fe.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)
  InChIKey MVZXTUSAYBWAAM-UHFFFAOYSA-N
  Canonical SMILES OS(=O)(=O)O.[Fe]
  External Link
Pubchem ID 105075
CAS Number 9004-66-4
TTD ID D08OKJ

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM003  Affected organization distribution
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM009  Altered absorption (Unspecific)
BM013  Competitive binding of plasma proteins
BM048  Increased risk of angioedema/anaphylactoid reactions
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Iron Dextran
      Affected gastrointestinal absorption
   Altered absorption (Unspecific) Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0649
 
Ferrous fumarate
 
C4H2FeO4
 
6433164 
Moderate    Inter Info   
[10], [11], [12], [1], [13]
D0650
 
Ferrous gluconate
 
C12H22FeO14
 
23616740 
Moderate    Inter Info   
[10], [11], [12], [1], [13]
D0651
 
Ferrous sulfate anhydrous
 
FeO4S
 
24393 
Moderate    Inter Info   
[11], [1], [13]
D0847
 
Iron
 
Fe
 
23925 
Moderate    Inter Info   
[11], [1], [13]
D0849
 
Iron protein succinylate
 
NA
 
NA
Moderate    Inter Info   
[10], [11], [12], [1], [13]
      Affected organization distribution
   Competitive binding of plasma proteins Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0708
 
Gallium chloride Ga-67
 
Cl3Ga
 
73415785 
Moderate    Inter Info   
[14]
      Pharmacodynamic additive effects
   Increased risk of angioedema/anaphylactoid reactions Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0156
 
Benazepril
 
C24H28N2O5
 
5362124 
Major    Inter Info   
[1], [2], [3]
D0567
 
Enalapril
 
C20H28N2O5
 
5388962 
Major    Inter Info   
[1], [2], [3]
D0695
 
Fosinopril
 
C30H46NO7P
 
55891 
Major    Inter Info   
[1], [2], [3]
D0254
 
Captopril
 
C9H15NO3S
 
44093 
Major    Inter Info   
[1], [2], [3]
D0938
 
Lisinopril
 
C21H31N3O5
 
5362119 
Major    Inter Info   
[1], [2], [3]
D1082
 
Moexipril
 
C27H34N2O7
 
91270 
Major    Inter Info   
[1], [2], [3]
D1256
 
Perindopril
 
C19H32N2O5
 
107807 
Major    Inter Info   
[1], [2], [3]
D1369
 
Quinapril
 
C25H30N2O5
 
54892 
Major    Inter Info   
[1], [2], [3]
D1379
 
Ramipril
 
C23H32N2O5
 
5362129 
Major    Inter Info   
[1], [2], [3]
D1618
 
Trandolapril
 
C24H34N2O5
 
5484727 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1776
 
Dimercaprol
 
C3H8OS2
 
3080 
Major    Inter Info   
[4], [5], [6]
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Moderate    Inter Info   
[7], [8], [9]
D1703
 
Vitamin E
 
C29H50O2
 
14985 
Moderate    Inter Info   
[15], [16]
References
1 Product Information. INFeD (iron dextran). Schein Pharmaceuticals Inc, Florham Park, NJ.
2 Chertow GM, Mason PD, Vaage-Nilsen O, Ahlmen J "On the relative safety of parenteral iron formulations." Nephrol Dial Transplant 19 (2004): 1571-5.[PMID: 15150356]
3 Bailie GR, Clark JA, Lane CE, Lane PL "Hypersensitivity reactions and deaths associated with intravenous iron preparations." Nephrol Dial Transplant 20 (2005): 1443-9.[PMID: 15855210]
4 Desmedt S, Spinewine A, Jadoul M, Henrard S, Wouters D, Dalleur O. Impact of a clinical decision support system for drug dosage in patients with renal failure.?Int J Clin Pharm. 2018;40(5):1225-1233. [PMID: 29785684]
5 Chenoweth MB "Clinical uses of metal-binding drugs." Clin Pharmacol Ther 9 (1968): 365-87. [PMID: 4984845]
6 Product Information. BAL in Oil (dimercaprol). Becton Dickinson, Franklin Lakes, NJ.
7 Saidi P, Wallerstein RO, Aggeler PM "Effect of chloramphenicol on erythropoiesis." J Lab Clin Med 57 (1961): 247-56
8 Haile CA "Chloramphenicol toxicity." South Med J 70 (1977): 479-80
9 Scott JL, Finegold SY, Belkin GA, Lawrence JS "A controlled double-blind study of the hematologic toxicity of chloramphenicol." N Engl J Med 272 (1965): 1137-42
10 Product Information. Accrufer (ferric maltol). Shield Therapeutics, Wilmington, DE.
11 Product Information. Feraheme (ferumoxytol). Alza Pharmaceuticals, Mountain View, CA.
12 Product Information. Ferrlecit (sodium ferric gluconate complex). sanofi-aventis, Bridgewater, NJ.
13 Product Information. Venofer (iron sucrose) American Regent Laboratories Inc, Shirley, NY.
14 Product Information. Gallium Citrate Ga-67 (gallium citrate 67 Ga (gallium citrate 67Ga)). Bristol-Myers Squibb, Princeton, NJ.
15 Graeber JE, Williams ML, Oski FA "The use of intramuscular vitamin E in the premature infant. Optimum dose and iron interaction." J Pediatr 90 (1977): 282-4
16 Melhorn DK, Gross S "Relationships between iron-dextran and vitamin E in iron deficiency anemia in children." J Lab Clin Med 74 (1969): 789-802