Details of Drug

Drug General Information (ID: D0820)
Drug Name	Insulin lispro (protamine)
Drug Type	Small molecule
Drug Synonymous	WNRQPCUGRUFHED-DETKDSODSA-N; Insulin lispro [USAN:BAN:INN]; Humalog (TN); Insulin Lispro Click to Show/Hide
Disease Class	5A2Y: Acute diabete complication
Therapeutic Class	Antidiabetic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C257H389N65O77S6
InChI	1S/C158H234N40O42S2.C99H155N25O35S4/c1-79(2)57-104(181-131(213)86(15)173-136(218)102(50-53-125(211)212)179-152(234)127(84(11)12)194-148(230)107(60-82(7)8)184-145(227)113(67-95-70-166-78-172-95)189-150(232)115(74-199)176-123(208)73-170-134(216)116(75-241)191-140(222)105(58-80(3)4)182-144(226)112(66-94-69-165-77-171-94)188-138(220)101(48-51-119(161)204)178-146(228)114(68-120(162)205)190-153(235)126(83(9)10)193-132(214)98(160)61-89-31-21-18-22-32-89)139(221)185-110(64-92-40-44-96(202)45-41-92)142(224)183-106(59-81(5)6)147(229)195-128(85(13)14)154(236)192-117(76-242)135(217)169-71-121(206)174-100(49-52-124(209)210)137(219)177-99(38-29-55-167-158(163)164)133(215)168-72-122(207)175-108(62-90-33-23-19-24-34-90)141(223)186-109(63-91-35-25-20-26-36-91)143(225)187-111(65-93-42-46-97(203)47-43-93)149(231)196-129(87(16)200)155(237)180-103(37-27-28-54-159)156(238)198-56-30-39-118(198)151(233)197-130(88(17)201)157(239)240;1-12-46(9)77(121-73(134)36-100)97(156)122-76(45(7)8)95(154)108-56(25-29-75(137)138)80(139)105-54(23-27-70(102)131)83(142)117-66(40-161)93(152)119-68(42-163)94(153)124-79(48(11)127)98(157)116-64(38-126)90(149)123-78(47(10)13-2)96(155)120-67(41-162)92(151)115-63(37-125)89(148)110-58(31-44(5)6)85(144)111-59(32-49-14-18-51(128)19-15-49)86(145)106-53(22-26-69(101)130)81(140)109-57(30-43(3)4)84(143)107-55(24-28-74(135)136)82(141)113-61(34-71(103)132)88(147)112-60(33-50-16-20-52(129)21-17-50)87(146)118-65(39-160)91(150)114-62(99(158)159)35-72(104)133/h18-26,31-36,40-47,69-70,77-88,98-118,126-130,199-203,241-242H,27-30,37-39,48-68,71-76,159-160H2,1-17H3,(H2,161,204)(H2,162,205)(H,165,171)(H,166,172)(H,168,215)(H,169,217)(H,170,216)(H,173,218)(H,174,206)(H,175,207)(H,176,208)(H,177,219)(H,178,228)(H,179,234)(H,180,237)(H,181,213)(H,182,226)(H,183,224)(H,184,227)(H,185,221)(H,186,223)(H,187,225)(H,188,220)(H,189,232)(H,190,235)(H,191,222)(H,192,236)(H,193,214)(H,194,230)(H,195,229)(H,196,231)(H,197,233)(H,209,210)(H,211,212)(H,239,240)(H4,163,164,167);14-21,43-48,53-68,76-79,125-129,160-163H,12-13,22-42,100H2,1-11H3,(H2,101,130)(H2,102,131)(H2,103,132)(H2,104,133)(H,105,139)(H,106,145)(H,107,143)(H,108,154)(H,109,140)(H,110,148)(H,111,144)(H,112,147)(H,113,141)(H,114,150)(H,115,151)(H,116,157)(H,117,142)(H,118,146)(H,119,152)(H,120,155)(H,121,134)(H,122,156)(H,123,149)(H,124,153)(H,135,136)(H,137,138)(H,158,159)/t86-,87+,88+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,126-,127-,128-,129-,130-;46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-,77-,78-,79-/m00/s1
InChIKey	WNRQPCUGRUFHED-DETKDSODSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CS)C(=O)NC(CS)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CS)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)CN.CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CS)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)O)C(=O)O)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)CNC(=O)C(CS)NC(=O)C(CC(C)C)NC(=O)C(CC7=CN=CN7)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC8=CC=CC=C8)N
External Link
	Pubchem ID	16132438
	CAS Number	133107-64-9
	TTD ID	D0L6JE

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM064 Increased risk of hypoglycemia BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Insulin lispro (protamine)
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0670		Fludeoxyglucose (18F)	C6H11FO5	170049	Moderate		Inter Info	[39], [40], [41]
Pharmacodynamic additive effects
	Increased risk of hypoglycemia					Drug Num: 113
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[9], [10], [11]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[12], [13], [14]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[15], [16], [17]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[9], [10], [11]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[9], [10], [11]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[18], [19], [20]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[21], [22], [23]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[9], [10], [11]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[24], [25], [26]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[9], [10], [11]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[9], [10], [11]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[21], [27], [28]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[9], [10], [11]
D1759		Chromic chloride	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[9], [10], [11]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[32], [33], [34]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[24], [25], [26]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[35], [36], [37]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[9], [10], [11]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[18], [19], [20]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[9], [10], [11]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[9], [10], [11]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[35], [36], [37]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[12], [13], [38]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[24], [25], [26]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[9], [10], [11]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[9], [10], [11]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[24], [25], [26]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[9], [10], [11]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[9], [10], [11]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[12], [13], [38]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[18], [19], [20]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[9], [10], [11]
D0643		Fenofibric acid	C17H15ClO4	64929	Moderate		Inter Info	[9], [10], [11]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[9], [10], [11]
D0677		Fluoxymesterone	C20H29FO3	6446	Moderate		Inter Info	[9], [10], [11]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[9], [10], [11]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[9], [10], [11]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[9], [10], [11]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[9], [10], [11]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[21], [27], [28]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[21], [27], [28]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[21], [27], [28]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[9], [10], [11]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[9], [10], [11]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[9], [10], [11]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[15], [16], [17]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[9], [10], [11]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[12], [13], [14]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[9], [10], [11]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[12], [13], [14]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[18], [19], [20]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[9], [10], [11]
D0984		Mecasermin	NA	NA	Moderate		Inter Info	[9], [10], [11]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[18], [19], [20]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[25], [45], [46]
D1042		Methyltestosterone	C20H30O2	6010	Moderate		Inter Info	[9], [10], [11]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[47], [48], [49]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[47], [50], [49]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[35], [36], [37]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[9], [10], [11]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[9], [10], [11]
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[18], [19], [20]
D1195		Oxandrolone	C19H30O3	5878	Moderate		Inter Info	[9], [10], [11]
D1207		Oxymetholone	C21H32O3	5281034	Moderate		Inter Info	[9], [10], [11]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[9], [10], [11]
D1862		Pegvisomant	NA	NA	Moderate		Inter Info	[51], [49], [52]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[9], [10], [11]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[9], [10], [11]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[18], [19], [20]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[9], [10], [11]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[18], [19], [20]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[9], [10], [11]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[47], [56], [49]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[9], [10], [11]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[9], [10], [11]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[9], [10], [11]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[9], [10], [11]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[9], [10], [11]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[57], [58], [59]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[9], [10], [11]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[9], [10], [11]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[15], [16], [17]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[9], [10], [11]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[12], [13], [38]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[9], [10], [11]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[18], [19], [20]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[15], [16], [17]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[9], [10], [11]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[9], [10], [11]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[9], [10], [11]
D1519		Sulfisoxazole	C11H13N3O3S	5344	Moderate		Inter Info	[9], [10], [11]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[9], [10], [11]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[9], [10], [11]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[9], [10], [11]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[35], [36], [37]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[21], [27], [28]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[21], [27], [28]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[9], [10], [11]
D1661		Turmeric	C21H20O6	969516	Moderate		Inter Info	[60], [61], [62]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[9], [10], [11]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[9], [10], [11]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[9], [10], [11]
D0711		Garlic	NA	NA	Minor		Inter Info	[69], [70], [71]
D1836		Lipoic acid	C8H14O2S2	6112	Minor		Inter Info	[49], [72], [73]
D1086		Monopotassium phosphate	H2KO4P	516951	Minor		Inter Info	[74], [75], [76]
D1271		Phentolamine	C17H19N3O	5775	Minor		Inter Info	[49], [77], [78]
D1303		Plantago seed	NA	NA	Minor		Inter Info	[79], [80], [81]
D1316		Potassium acetate	C2H3KO2	517044	Minor		Inter Info	[74], [75], [76]
D1317		Potassium bicarbonate	CHKO3	516893	Minor		Inter Info	[74], [75], [76]
D1318		Potassium chloride	ClK	4873	Minor		Inter Info	[74], [75], [76]
D1319		Potassium citrate	C6H5K3O7	13344	Minor		Inter Info	[74], [75], [76]
D1320		Potassium gluconate	C6H11KO7	16760467	Minor		Inter Info	[74], [75], [76]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 159
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1], [2], [3]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Major		Inter Info	[1], [2], [3]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[4], [5], [1]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[1], [2], [3]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1], [2], [3]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[1], [2], [3]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[1], [2], [3]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1], [2], [3]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Major		Inter Info	[1], [2], [3]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[6], [7], [8]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[6], [7], [8]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[6], [7], [8]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[6], [7], [8]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[6], [7], [8]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[6], [7], [8]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[6], [7], [8]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[6], [7], [8]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[6], [7], [8]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[6], [7], [8]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[6], [7], [8]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[6], [7], [8]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[6], [7], [8]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[6], [7], [8]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[6], [7], [8]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[6], [7], [8]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[6], [7], [8]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[6], [7], [8]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[6], [7], [8]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[6], [7], [8]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[6], [7], [8]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[6], [7], [8]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[6], [7], [8]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[6], [7], [8]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[6], [7], [8]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[6], [7], [8]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[6], [7], [8]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[6], [7], [8]
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[6], [7], [8]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[6], [7], [8]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[6], [7], [8]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[6], [7], [8]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[6], [7], [8]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[6], [7], [8]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[6], [7], [8]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[6], [7], [8]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[6], [7], [8]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[6], [7], [8]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[6], [7], [8]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[6], [7], [8]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[6], [7], [8]
D0608		Estramustine	C23H31Cl2NO3	259331	Moderate		Inter Info	[6], [7], [8]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[6], [7], [8]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[6], [7], [8]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[6], [7], [8]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[6], [7], [8]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[6], [7], [8]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[6], [7], [8]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[6], [7], [8]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[6], [7], [8]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[6], [7], [8]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[6], [7], [8]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[6], [7], [8]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[6], [7], [8]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[6], [7], [8]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[6], [7], [8]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[6], [7], [8]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[6], [7], [8]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[6], [7], [8]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[6], [7], [8]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[6], [7], [8]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[6], [7], [8]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[6], [7], [8]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[6], [7], [8]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[42], [43], [44]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[6], [7], [8]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[6], [7], [8]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[6], [7], [8]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[6], [7], [8]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[6], [7], [8]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[6], [7], [8]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[6], [7], [8]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[6], [7], [8]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[6], [7], [8]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[6], [7], [8]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[6], [7], [8]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[6], [7], [8]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[6], [7], [8]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[6], [7], [8]
D1129		Niacin	C6H5NO2	938	Moderate		Inter Info	[6], [7], [8]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[6], [7], [8]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[6], [7], [8]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[6], [7], [8]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[42], [43], [44]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[6], [7], [8]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[6], [7], [8]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[6], [7], [8]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[6], [7], [8]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[42], [43], [44]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[6], [7], [8]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[53], [54], [55]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[6], [7], [8]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[6], [7], [8]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[6], [7], [8]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[6], [7], [8]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[6], [7], [8]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[6], [7], [8]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[6], [7], [8]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[6], [7], [8]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[6], [7], [8]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[6], [7], [8]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[6], [7], [8]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[6], [7], [8]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[6], [7], [8]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[6], [7], [8]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[6], [7], [8]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[6], [7], [8]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[6], [7], [8]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[6], [7], [8]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[6], [7], [8]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[6], [7], [8]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[6], [7], [8]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[6], [7], [8]
D1531		Tagraxofusp	NA	NA	Moderate		Inter Info	[6], [7], [8]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[6], [7], [8]
D1900		Teprotumumab	NA	NA	Moderate		Inter Info	[6], [7], [8]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[6], [7], [8]
D1902		Tesamorelin	C221H366N72O67S	16137828	Moderate		Inter Info	[6], [7], [8]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[6], [7], [8]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[6], [7], [8]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[6], [7], [8]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[6], [7], [8]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[6], [7], [8]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[6], [7], [8]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[6], [7], [8]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[6], [7], [8]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[6], [7], [8]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[6], [7], [8]
D1707		Vorinostat	C14H20N2O3	5311	Moderate		Inter Info	[6], [7], [8]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[6], [7], [8]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[6], [7], [8]
D1735		Alclometasone (topical)	C22H29ClO5	5311000	Minor		Inter Info	[63], [64], [65]
D1737		Amcinonide	C28H35FO7	443958	Minor		Inter Info	[63], [64], [65]
D1748		Betamethasone (topical)	C22H29FO5	9782	Minor		Inter Info	[63], [64], [65]
D1762		Clobetasol (topical)	C22H28ClFO4	5311051	Minor		Inter Info	[63], [64], [65]
D1763		Clocortolone (topical)	C22H28ClFO4	5311052	Minor		Inter Info	[63], [64], [65]
D1770		Desonide (topical)	C24H32O6	5311066	Minor		Inter Info	[63], [64], [65]
D1771		Desoximetasone (topical)	C22H29FO4	5311067	Minor		Inter Info	[63], [64], [65]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Minor		Inter Info	[21], [51], [49]
D1773		Diflorasone (topical)	C22H28F2O5	71415	Minor		Inter Info	[63], [64], [65]
D0497		Diltiazem	C22H26N2O4S	39186	Minor		Inter Info	[66], [67], [68]
D1786		Fluocinonide (topical)	C26H32F2O7	9642	Minor		Inter Info	[63], [64], [65]
D1788		Flurandrenolide (topical)	C24H33FO6	15209	Minor		Inter Info	[63], [64], [65]
D0685		Fluticasone (topical)	C22H27F3O4S	5311101	Minor		Inter Info	[63], [64], [65]
D1804		Halcinonide (topical)	C24H32ClFO5	443943	Minor		Inter Info	[63], [64], [65]
D1813		Hydrocortisone (topical)	C21H30O5	5754	Minor		Inter Info	[63], [64], [65]
D1844		Methylprednisolone (topical)	C22H30O5	6741	Minor		Inter Info	[63], [64], [65]
D1869		Prednicarbate (topical)	C27H36O8	6714002	Minor		Inter Info	[63], [64], [65]
D1911		Triamcinolone (topical)	C21H27FO6	31307	Minor		Inter Info	[63], [64], [65]
D1916		Ulobetasol (topical)	C22H27ClF2O4	5311167	Minor		Inter Info	[63], [64], [65]
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1908		Thyrotropin alfa	C16H22N6O4	32281	Moderate		Inter Info	[6], [7], [8]

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