Drug General Information (ID: DDI9PXYNJ3)
Drug Name			Insulin lispro (protamine)		Drug Info		Glimepiride		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiabetic Agents				Antidiabetic Agents
Structure

Mechanism of Insulin lispro (protamine)-Glimepiride Interaction (Severity Level: Moderate)
Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph
Drug Name		Insulin lispro (protamine)				Glimepiride
Mechanism		Hypoglycemic effects				Hypoglycemic effects
Key Mechanism Factor 1
		Factor Name		Hypoglycemia
		Factor Description		Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating.
Mechanism Description		Increased risk of hypoglycemia by the combination of Insulin lispro (protamine) and Glimepiride

Recommended Action
Management		Caution and close blood glucose monitoring are advised during coadministration of these agents. A lower dosage of sulfonylurea or insulin may be required. Patients should be counseled to recognize the symptoms of hypoglycemia such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitation, and tachycardia. If hypoglycemia occurs, patients should initiate appropriate remedial therapy immediately and contact their physician. Patients should also be advised to take precautions to avoid hypoglycemia while driving or operating hazardous machinery.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
3	Product Information. Humulin N (insulin isophane). Lilly, Eli and Company, Indianapolis, IN.