Details of Drug

Drug General Information (ID: D0752)
Drug Name	Hemin
Drug Type	Small molecule
Drug Synonymous	heme; protoheme; Haem; ferroprotoporphyrin; UNII-42VZT0U6YR; Iron protoporphyrin ix; Protohaem; Ferroheme; Reduced hematin; Ferrous protoheme; Iron protoporphyrin; Ferrous protoheme IX; Ferroprotoporphyrin IX; 14875-96-8; 42VZT0U6YR; Iron(II) protoporphyrin IX; Protoheme IX (VAN); Ferroheme (VAN); Heme (VAN); 85758-EP2305825A1; 85758-EP2305243A1; 85758-EP2270505A1; 85758-EP2270016A1; 3-[18-(2-carboxyethyl)-7,12-bis(ethenyl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid; iron(2+); NSC 16669; NSC 267100; AC1L9FPJ; Hemin Click to Show/Hide
Therapeutic Class	Heme Iron Supplement
Structure
Structure	3D Structure		2D Structure
Formula	C34H32FeN4O4
InChI	1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2
InChIKey	KABFMIBPWCXCRK-UHFFFAOYSA-L
Canonical SMILES	CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C)CCC(=O)O)CCC(=O)O.[Fe+2]
External Link
	Pubchem ID	26945
	CAS Number	14875-96-8
	TTD ID	D0UU1I
	VARIDT ID	DR00298

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM050 Increased risk of bleeding BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Hemin
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 55
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Moderate		Inter Info	[1]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[1]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[1]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[1]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[1]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[1]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[1]
D0537		Drotrecogin alfa	NA	NA	Moderate		Inter Info	[1]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[1]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[1]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Moderate		Inter Info	[1]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[1]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[1]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[1]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[1]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[1]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[1]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[1]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[1]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[1]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[1]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Moderate		Inter Info	[1]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[1]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[1]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[1]
D1380		Ramucirumab	NA	NA	Moderate		Inter Info	[1]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[1]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[1]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[1]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[1]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[1]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[1]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0784		Ibritumomab tiuxetan	NA	NA	Moderate		Inter Info	[1]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[1]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[1]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[1]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[1]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[1]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[1]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[1]
D1614		Tositumomab (I-131)	NA	NA	Moderate		Inter Info	[1]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[1]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0071		Amobarbital	C11H18N2O3	2164	Major		Inter Info	[1]
D0224		Butabarbital	C10H16N2O3	2479	Major		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Major		Inter Info	[1]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Major		Inter Info	[1]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Major		Inter Info	[1]
D0416		Danazol	C22H27NO2	28417	Major		Inter Info	[1]
D0606		Estradiol	C18H24O2	5757	Major		Inter Info	[1]
D0607		Estradiol (topical)	C18H24O2	5757	Major		Inter Info	[1]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[1]
D0605		Esterified estrogens	NA	NA	Major		Inter Info	[1]
D0610		Estrone sulfate	C18H22O5S	3001028	Major		Inter Info	[1]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Major		Inter Info	[1]
D1011		Mestranol	C21H26O2	6291	Major		Inter Info	[1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Major		Inter Info	[1]
D1248		Pentobarbital	C11H18N2O3	4737	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1]
D1453		Secobarbital	C12H18N2O3	5193	Major		Inter Info	[1]

References
1	Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ.

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