Drug General Information (ID: DDIHU05VCF)
Drug Name			Hemin		Drug Info		Esterified estrogens		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Heme Iron Supplement				Estrogens

Mechanism of Hemin-Esterified estrogens Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Hemin				Esterified estrogens
Mechanism		Hemin				Reduce the pharmacological effect of hemin
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Hemin when combined with Esterified estrogens

Recommended Action
Management		Drugs capable of increasing the activity of delta-aminolevulinic acid synthetase should be avoided during hemin therapy.

References
1	Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ.