Drug General Information (ID: DDICA6WLZY)
Drug Name			Estradiol (topical)		Drug Info		Hemin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Estrogens				Heme Iron Supplement
Structure

Mechanism of Estradiol (topical)-Hemin Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Estradiol (topical)				Hemin
Mechanism		Reduce the pharmacological effect of hemin				Hemin
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Hemin when combined with Estradiol (topical)

Recommended Action
Management		Drugs capable of increasing the activity of delta-aminolevulinic acid synthetase should be avoided during hemin therapy.

References
1	Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ.