Details of Drug

Drug General Information (ID: D0745)
Drug Name	Guanfacine
Drug Type	Small molecule
Drug Synonymous	GUANFACINE; 29110-47-2; Guanfacinum [INN-Latin]; Guanfacina [INN-Spanish]; N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide; UNII-30OMY4G3MK; Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-; 30OMY4G3MK; N-amidino-2-(2,6-dichlorophenyl)acetamide; CHEBI:5558; N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide; SPD 503; Guanfacina; Guanfacinum; Guanfacine [INN:BAN]; NSC-759121; NCGC00015469-05; EINECS 249-442-8; Guanfacine (INN); Estulic (TN); Tenex (Salt/Mix); Estulic (Salt/Mix); Tocris-1030; Prestwick0_000339; Prestwick1_000339; Prestwick2_000339; Prestwick3_000339; Guanfacine-13C-15N3; Lopac-G-1043; CHEMBL862; LON 798 (Salt/Mix); Lopac0_000519; SCHEMBL35094; BSPBio_000377; GTPL522; RASPBERRYKETONEGLUCOSIDE; SPBio_002298; BPBio1_000415; DTXSID9046944; BDBM81984; BCP09647; NSC_3519; ZINC3872738; Guanfacine hydrochloride (Salt/Mix); HY-17416A; (2,6-dichlorophenylacetyl)-guanidine; [(2,6-dichlorophenyl)acetyl]guanidine; AKOS030255657; CCG-204609; DB01018; NSC 759121; SDCCGSBI-0050502.P002; MRF-0000019; NCGC00015469-01; NCGC00015469-02; NCGC00015469-03; NCGC00015469-04; NCGC00015469-06; NCGC00015469-07; NCGC00024950-01; NCGC00024950-02; NCGC00024950-03; CAS-29110-48-3; CAS_29110-47-2; FT-0669067; FT-0669068; C07037; D08031; AB01563079_01; A902647; A918619; L000286; L013430; J-017394; Q5613599; BRD-K32830106-003-03-0; BRD-K32830106-003-11-3; N-(Diaminomethyliden)-2-(2,6-dichlorophenyl)acetamid; [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride;Guanfacine HCl Click to Show/Hide
Therapeutic Class	Antiadrenergic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C9H9Cl2N3O
InChI	InChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15)
InChIKey	INJOMKTZOLKMBF-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
External Link
	Pubchem ID	3519
	VARIDT ID	DR01628

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Guanfacine
Affected cellular transport
	Transporter inhibition					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[1]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[6], [1], [46]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[1], [48], [49]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[1]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Moderate		Inter Info	[49], [51]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[1], [53]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[1], [56], [4]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[6], [1], [58]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[1], [71], [72]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[1]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 79
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[1], [2]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[1], [2]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1], [2]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1], [2]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1], [2]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1], [2]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[1], [2]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1], [2]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[1], [2], [4]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[1], [2]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[1], [2]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1], [2]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1], [2]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[1], [2]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[1], [2], [4]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[1], [2]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[1], [2]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[1], [2], [4]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[1], [2]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[1], [2]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[1], [2]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[1], [2]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[1], [2]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1], [2]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[1], [2]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1], [2]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[1], [2]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[1], [2]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[41]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[1], [2]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1], [2]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1], [2]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1], [2]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[1], [2]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[57]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[1], [2]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1], [2]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1], [2]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1], [2]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[60]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[1], [2]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1], [2]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[1], [2]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1], [2]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[6], [1]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[1], [2]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[1], [2]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1], [2]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1], [2]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1], [2]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1], [2]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1], [2]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1], [2]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1], [2]
	CYP450 enzyme induction					Drug Num: 51
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1], [3], [2]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1], [3], [2]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1], [3], [2]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1], [3], [2]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[1], [3], [2]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[1], [3], [2]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1], [3], [2]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[1], [3], [2]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[1], [3], [2]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[1], [3], [2]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[1], [3], [2]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1], [3], [2]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1], [3], [2]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1], [3], [2]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [3], [2]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1], [3], [2]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[1], [3], [2]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[1], [3], [2]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[1], [3], [2]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [3], [2]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1], [3], [2]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1], [3], [2]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1], [3], [2]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1], [3], [2]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1], [3], [2]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1], [3], [2]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1], [3], [2]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1], [3], [2]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1], [3], [2]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1], [3], [2]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1], [3], [2]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[6], [52]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[1], [3], [2]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1], [3], [2]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1], [3], [2]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[1], [3], [2]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[1], [3], [2]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[1], [3], [2]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1], [3], [2]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1], [3], [2]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1], [3], [2]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1], [3], [2]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1], [3], [2]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [86]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1], [3], [2]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[1], [3], [2]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1], [3], [2]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1], [3], [2]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1], [3], [2]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1], [3], [2]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1], [3], [2]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[1]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[8], [9], [10]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[8], [9], [10]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[8], [9], [10]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[8], [9], [10]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[8], [9], [10]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[8], [9], [10]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[47]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[8], [9], [10]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[8], [9], [10]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[8], [9], [10]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[8], [9], [10]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[8], [9], [10]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[59]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[8], [9], [10]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[8], [9], [10]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[8], [9], [10]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[8], [9], [10]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[8], [9], [10]
	Additive hypotensive effects					Drug Num: 176
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[5]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[6], [1], [4]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[7]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[6], [1], [4]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[6], [1], [4]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[11], [12], [13]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[14], [15], [16]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[5], [17], [18]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[19], [20], [21]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[6], [1], [4]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[6], [1], [4]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[5], [17], [18]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[5], [17], [18]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[5], [17], [18]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[14], [15], [16]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[14], [15], [16]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[6], [1], [4]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[19], [20], [21]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[19], [20], [21]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[19], [20], [21]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[5], [17], [18]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[5], [17], [18]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[6], [1], [4]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[19], [20], [21]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[6], [1], [4]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[19], [20], [21]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[6], [34], [35]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[19], [20], [21]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[6], [1], [4]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[19], [20], [21]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[6], [1], [4]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[6], [1], [4]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[5], [17], [18]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[19], [20], [21]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[19], [20], [21]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[36], [37]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[6], [1], [4]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[6], [1], [4]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[5], [17], [18]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[27], [29], [31]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[6], [1], [4]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[11], [36], [42]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[43], [44], [45]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[6], [1], [4]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[19], [20], [21]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[6], [1], [50]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[6], [1], [4]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[5], [17], [18]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[19], [20], [21]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[19], [20], [21]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[6], [1], [4]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[6], [1], [50]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[19], [20], [21]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[6], [1], [4]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[19], [20], [21]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[19], [20], [21]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[6], [1], [50]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[1], [54], [55]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[6], [1], [4]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[6], [1], [4]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[6], [1], [4]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[1], [54], [55]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[6], [1], [4]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[5], [17], [18]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[5], [17], [18]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[11], [12], [61]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[65]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[5], [17], [18]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[5], [17], [18]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[5], [17], [18]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[66], [36], [67]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[68], [69], [70]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[19], [20], [21]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[19], [20], [21]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [36], [83], [84]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[19], [20], [21]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[5], [17], [18]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[6], [1], [4]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [36], [83], [84]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[19], [20], [21]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [36], [83], [84]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[85]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [36], [83], [84]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [36], [83], [84]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[1], [54], [55]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[6], [1], [4]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[19], [20], [21]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[6], [1], [4]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[88], [66], [36]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[6], [1], [4]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[19], [20], [21]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[6], [1], [4]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[19], [20], [21]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[6], [1], [4]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[19], [20], [21]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[6], [1], [4]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[6], [1], [4]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[5], [17], [18]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [36], [83], [84]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[6], [1], [4]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[6], [1], [4]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[6], [1], [4]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[19], [20], [21]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[19], [20], [21]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[6], [1], [4]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[6], [1], [4]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[6], [1], [4]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[6], [1], [4]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[19], [20], [21]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[6], [1], [4]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[19], [20], [21]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[6], [1], [4]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[6], [1], [4]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[6], [1], [4]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[6], [1], [4]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[4], [89], [90]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[91]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[6], [1], [4]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [36], [83], [84]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[6], [1], [4]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[6], [1], [4]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[5], [17], [18]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[6], [1], [4]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[5], [17], [18]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[6], [1], [4]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[6], [1], [4]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[43], [44], [45]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[5], [17], [18]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[6], [1], [4]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[6], [1], [4]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[6], [1], [4]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[5], [17], [18]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[5], [17], [18]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[6], [1], [4]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[6], [1], [4]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [36], [83], [84]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[1], [54], [55]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[6], [1], [4]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[6], [1], [4]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[43], [44], [45]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[19], [20], [21]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[19], [20], [21]
D0711		Garlic	NA	NA	Minor		Inter Info	[93], [94]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[95], [96]
	Increased risk of bradycardia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[38], [39], [40]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[6], [87]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[1], [22]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[1], [22]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[1], [22]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[1], [22]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[62], [63], [64]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[1], [22]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[1], [22]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[1], [22]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[1], [22]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[1], [22]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[92], [36]

References
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