Details of Drug

Drug General Information (ID: D0734)
Drug Name	Glycopyrronium (topical)
Drug Type	Small molecule
Drug Synonymous	13283-82-4; (1,1-dimethylpyrrolidin-1-ium-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate; Glycopyrronium (USAN); NCGC00179456-02; Tovanor Breezhaler; zlchem 10; beta-1-Methyl-3-pyrrolidyl-alpha-cyclopentylmandelate methobromide; G00010-Watson-Int; Prestwick2_000746; Prestwick1_000746; Prestwick3_000746; Prestwick0_000746; AC1Q60WT; BSPBio_000732; SCHEMBL133002; SPBio_002671; AC1L1G28; BPBio1_000806; GTPL7459; Pyrrolidinium, Click to Show/Hide
Disease Class	8A20: Alzheimer disease
Therapeutic Class	Topical Agents
Structure
Structure	3D Structure		2D Structure
Formula	C19H28NO3+
InChI	1S/C19H28NO3/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3/q+1
InChIKey	ANGKOCUUWGHLCE-UHFFFAOYSA-N
Canonical SMILES	C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C
External Link
	Pubchem ID	3494
	CAS Number	13283-82-4
	CHEBI ID	94449
	TTD ID	D0IL1B

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM033 Additive anticholinergic effects BM091 Antagonize the effect of cholinergic agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Glycopyrronium (topical)
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 81
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[1], [2], [3]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[1], [2], [3]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[1], [2], [3]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[1], [2], [3]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[1], [2], [3]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[1], [2], [3]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[1], [2], [3]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[1], [2], [3]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[1], [2], [3]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[1], [2], [3]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[1], [2], [3]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[1], [2], [3]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[1], [2], [3]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[1], [2], [3]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[1], [2], [3]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[1], [2], [3]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[1], [2], [3]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[1], [2], [3]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[1], [2], [3]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[1], [2], [3]
D0019		Aclidinium	C26H30NO4S2+	11434515	Moderate		Inter Info	[1], [2], [3]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[1], [2], [3]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[1], [2], [3]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[1], [2], [3]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[1], [2], [3]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[1], [2], [3]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[1], [2], [3]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[1], [2], [3]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[1], [2], [3]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[1], [2], [3]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[1], [2], [3]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[1], [2], [3]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[1], [2], [3]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[1], [2], [3]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[1], [2], [3]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[1], [2], [3]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[1], [2], [3]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[1], [2], [3]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[1], [2], [3]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[1], [2], [3]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[1], [2], [3]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[1], [2], [3]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[1], [2], [3]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[1], [2], [3]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[1], [2], [3]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[1], [2], [3]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[1], [2], [3]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[1], [2], [3]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[1], [2], [3]
D1590		Tiotropium	C19H22NO4S2+	5487427	Moderate		Inter Info	[1], [2], [3]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[1], [2], [3]
D1665		Umeclidinium	C29H34NO2+	11519070	Moderate		Inter Info	[1], [2], [3]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[1], [2], [3]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[1], [2], [3]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[1], [2], [3]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[1], [2], [3]
D0842		Ipratropium	C20H30NO3+	657309	Moderate		Inter Info	[1], [2], [3]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[1], [2], [3]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[1], [2], [3]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[1], [2], [3]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[1], [2], [3]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[1], [2], [3]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[1], [2], [3]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[1], [2], [3]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[1], [2], [3]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[1], [2], [3]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[1], [2], [3]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[1], [2], [3]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1], [2], [3]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[1], [2], [3]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[1], [2], [3]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[1], [2], [3]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[1], [2], [3]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[1], [2], [3]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[1], [2], [3]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[1], [2], [3]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[1], [2], [3]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[1], [2], [3]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[1], [2], [3]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[1], [2], [3]
D0843		Ipratropium (nasal)	C20H30NO3+	657309	Minor		Inter Info	[10], [11], [12]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[8], [9]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[4], [5]
D0440		Demecarium (ophthalmic)	C32H52N4O4+2	5966	Moderate		Inter Info	[6], [7]
D0015		Acetylcholine	C7H16NO2+	187	Moderate		Inter Info	[6], [7]
D0175		Bethanechol	C7H17N2O2+	2370	Moderate		Inter Info	[4], [5]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Moderate		Inter Info	[6], [7]
D1288		Pilocarpine	C11H16N2O2	5910	Moderate		Inter Info	[4], [5]
D1289		Pilocarpine (ophthalmic)	C11H16N2O2	5910	Moderate		Inter Info	[6], [7]
D0856		Isoflurophate (ophthalmic)	C6H14FO3P	5936	Moderate		Inter Info	[6], [7]
D1286		Physostigmine (ophthalmic)	C15H21N3O2	5983	Moderate		Inter Info	[6], [7]

References
1	Product Information. Anoro Ellipta (umeclidinium-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
2	Product Information. Combivent (albuterol-ipratropium). Boehringer-Ingelheim, Ridgefield, CT.
3	Product Information. Qbrexza (glycopyrrolate topical). Dermira, Inc., Menlo Park, CA.
4	Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255. [PMID: 376469]
5	Product Information. Salagen Tablets (pilocarpine). Boehringer-Ingelheim, Ridgefield, CT.
6	Multum Information Services, Inc. Expert Review Panel.
7	Product Information. Pilopine HS (pilocarpine ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
8	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
10	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
11	Product Information. Atrovent nasal spray (ipratropium nasal). Boehringer-Ingelheim, Ridgefield, CT.
12	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.

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