Details of Drug Interaction | MecDDI

Drug General Information (ID: DDIQBZS5YV)
Drug Name			Methdilazine		Drug Info		Glycopyrronium (topical)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihistamines				Topical Agents
Structure

Mechanism of Methdilazine-Glycopyrronium (topical) Interaction (Severity Level: Moderate)
Additive anticholinergic effects Click to Show/Hide Mechanism Graph

Drug Name		Methdilazine				Glycopyrronium (topical)
Mechanism		Anticholinergic effects Muscarinic acetylcholine receptor Antagonist				Anticholinergic effects Muscarinic acetylcholine receptor Antagonist
Key Mechanism Factor 1
		Factor Name		Muscarinic acetylcholine receptor M				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Click to Show/Hide
Mechanism Description		Additive anticholinergic effects by the combination of Methdilazine and Glycopyrronium (topical)

Recommended Action
Management		Topical and inhaled anticholinergic preparations should preferably not be used in combination with other anticholinergic agents or agents with significant anticholinergic effects such as antihistamines, antispasmodics, neuroleptics, phenothiazines, skeletal muscle relaxants, tricyclic antidepressants, and class IA antiarrhythmics (especially disopyramide). Caution is advised if concomitant use cannot be avoided, particularly in the elderly and those with significantly impaired renal and/or hepatic function.

References
1	Product Information. Anoro Ellipta (umeclidinium-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
2	Product Information. Combivent (albuterol-ipratropium). Boehringer-Ingelheim, Ridgefield, CT.
3	Product Information. Qbrexza (glycopyrrolate topical). Dermira, Inc., Menlo Park, CA.