Details of Drug-Drug Interaction
| Drug General Information (ID: DDI81A9OTY) | |||||||||
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| Drug Name | Glycopyrronium (topical) | Drug Info | Acetylcholine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Topical Agents | Cardiovascular Agents | |||||||
| Structure | |||||||||
| Mechanism of Glycopyrronium (topical)-Acetylcholine Interaction (Severity Level: Moderate) | |||||||||
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| Antagonize the effect of cholinergic agents Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Glycopyrronium (topical) | Acetylcholine | |||||||
| Mechanism |
Anticholinergic effects Muscarinic acetylcholine receptor Antagonist |
Cholinergic effects Muscarinic acetylcholine receptor Agonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Muscarinic acetylcholine receptor M | Structure Sequence | |||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Patients receiving long-term therapy with anticholinergic agents should be monitored for potentially diminished therapeutic (miotic) response to ophthalmic cholinergic therapy, and dosages adjusted as necessary. | ||||||||
| References | |||||||||||||||||||
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| 1 | Multum Information Services, Inc. Expert Review Panel. | ||||||||||||||||||
| 2 | Product Information. Pilopine HS (pilocarpine ophthalmic). Alcon Laboratories Inc, Fort Worth, TX. | ||||||||||||||||||