Details of Drug

Details of Drug

 Drug General Information (ID: D0719)
  Drug Name
Gentamicin (topical)
  Drug Type Small molecule
  Drug Synonymous
Alcomicin; Apogen; Bristagen; Cidomycin; GENTAMYCIN; Garamycin; Garasol; Gentacidin; Gentacycol; Gentafair; Gentak; Gentamar; Gentamicina; Gentamicine; Gentamicins; Gentamicinum; Gentamycinum; Gentavet; Gentocin; Jenamicin; Refobacin; Uromycine; Garamycin Otic Solution; Genoptic Liquifilm; Gentamcin Sulfate; Gentamicin sulphate sterile; Refobacin TM; Gentamicin C1; G-Mycin; G-Myticin; Garamycin (TN); Gentamicin (BAN); Gentamicin (TN); Gentamicina [INN-Spanish]; Gentamicine [INN-French]; Gentamicinum [INN-Latin];Gentamycin-creme; Gentamycin-creme [German]; Ocu-Mycin; Spectro-Genta; U-Gencin; Genoptic S.O.P.; O-2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-alpha-D-ribo-heptopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy-D-streptamine; (1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-beta-L-lyxo-heptopyranoside; (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl (6x)-2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-alpha-D-erythro-heptopyranoside; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; 2-[4,6-diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; 4,6-diamino-3-{[3-deoxy-4-c-methyl-3-(methylamino)pentopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)heptopyranoside
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  Disease Class 1A00-1C4Z: Bacterial infection
  Therapeutic Class Antibiotics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C21H43N5O7
  InChI 1S/C21H43N5O7/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20/h9-20,25-29H,5-8,22-24H2,1-4H3
  InChIKey CEAZRRDELHUEMR-UHFFFAOYSA-N
  Canonical SMILES CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC
  External Link
Pubchem ID 3467
CAS Number 1403-66-3
TTD ID D0L9UU
INTEDE ID DR2174
VARIDT ID DR01198

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM045  Additive neuromuscular blocking effects
BM072  Increased risk of nephrotoxicity
BM073  Increased risk of ototoxicity
  Relation Graph
 Full list of drugs interacting with Gentamicin (topical)
      Pharmacodynamic additive effects
   Additive neuromuscular blocking effects Drug Num:  12
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0343
 
Cisatracurium
 
C53H72N2O12+2
 
62887 
Moderate    Inter Info   
[2], [3], [4]
D0122
 
Atracurium
 
C53H72N2O12+2
 
47319 
Moderate    Inter Info   
[2], [3], [4]
D0522
 
Doxacurium
 
C56H78N2O16+2
 
60169 
Moderate    Inter Info   
[2], [3], [4]
D1047
 
Metocurine
 
C40H48N2O6+2
 
21233 
Moderate    Inter Info   
[2], [3], [4]
D1080
 
Mivacurium
 
C58H80N2O14+2
 
5281042 
Moderate    Inter Info   
[2], [3], [4]
D1219
 
Pancuronium
 
C35H60N2O4+2
 
441289 
Moderate    Inter Info   
[2], [3], [4]
D1295
 
Pipecuronium
 
C35H62N4O4+2
 
50192 
Moderate    Inter Info   
[2], [3], [4]
D1384
 
Rapacuronium
 
C37H61N2O4+
 
5311399 
Moderate    Inter Info   
[2], [3], [4]
D1659
 
Tubocurarine
 
C37H41N2O6+
 
6000 
Moderate    Inter Info   
[2], [3], [4]
D1684
 
Vecuronium
 
C34H57N2O4+
 
39765 
Moderate    Inter Info   
[2], [3], [4]
D1420
 
Rocuronium
 
C32H53N2O4+
 
441290 
Moderate    Inter Info   
[2], [3], [4]
D1510
 
Succinylcholine
 
C14H30N2O4+2
 
5314 
Moderate    Inter Info   
[2], [3], [4]
   Increased risk of nephrotoxicity Drug Num:  8
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0056
 
Amikacin
 
C22H43N5O13
 
37768 
Moderate    Inter Info   
[1]
D0057
 
Amikacin (liposome)
 
C22H43N5O13
 
37768 
Moderate    Inter Info   
[1]
D0876
 
Kanamycin
 
C18H36N4O11
 
6032 
Moderate    Inter Info   
[1]
D1120
 
Neomycin
 
C23H46N6O13
 
8378 
Moderate    Inter Info   
[1]
D1126
 
Netilmicin
 
C21H41N5O7
 
441306 
Moderate    Inter Info   
[1]
D1304
 
Plazomicin
 
C25H48N6O10
 
42613186 
Moderate    Inter Info   
[1]
D1507
 
Streptomycin
 
C21H39N7O12
 
19649 
Moderate    Inter Info   
[1]
D1597
 
Tobramycin
 
C18H37N5O9
 
36294 
Moderate    Inter Info   
[1]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Geha DG, Blitt CD, Moon BJ "Prolonged neuromuscular blockade with pancuronium in the presence of acute renal failure: a case report." Anesth Analg 55 (1976): 343-5. [PMID: 945014]
3 Regan AG, Perumbetti PP "Pancuronium and gentamicin interaction in patients with renal failure." Anesth Analg 59 (1980): 393. [PMID: 6989291]
4 Warner WA, Sanders E "Neuromuscular blockade associated with gentamicin therapy." JAMA 215 (1971): 1153-4. [PMID: 4250687]