Details of Drug-Drug Interaction
| Drug General Information (ID: DDIC7FE2IZ) | |||||||||
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| Drug Name | Gentamicin (topical) | Drug Info | Mivacurium | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antibiotics | Neuromuscular Blocking Agents | |||||||
| Structure | |||||||||
| Mechanism of Gentamicin (topical)-Mivacurium Interaction (Severity Level: Moderate) | |||||||||
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| Additive neuromuscular blocking effects Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Gentamicin (topical) | Mivacurium | |||||||
| Mechanism |
Neuromuscular blocking effects Aminoglycosides |
Neuromuscular blocking agent Neuronal acetylcholine receptor Antagonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Neuronal acetylcholine receptor | Structure Sequence | |||||||
| Protein Family | Ligand-gated ion channel (TC 1.A.9) family | ||||||||
| Protein Function |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Topically applied aminoglycosides may be systemically absorbed, and significant absorption could occur in certain circumstances (e.g., application to burnt or broken skin use of large quantities or on large areas for prolonged periods). Clinicians should be aware of the potential for interaction if neuromuscular blockers are used in patients who have been treated extensively with topical aminoglycosides. Vital signs should be closely monitored, and ventilatory support should be readily available in case of respiratory arrest. Treatment with anticholinesterases and calcium may not always be effective in reversing the neuromuscular blockade caused by these agents. | ||||||||