Drug General Information (ID: DDIJTOQ2M1)
Drug Name			Gentamicin (topical)		Drug Info		Kanamycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antibiotics
Structure

Mechanism of Gentamicin (topical)-Kanamycin Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Gentamicin (topical)				Kanamycin
Mechanism 1		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Gentamicin (topical) and Kanamycin
Increased risk of ototoxicity Click to Show/Hide Mechanism Graph
Drug Name		Gentamicin (topical)				Kanamycin
Mechanism 2		Ototoxicity				Ototoxicity
Key Mechanism Factor 2
		Factor Name		Ototoxicity
		Factor Description		Ototoxicity is the damage to the organs of hearing and/or balance following exposure to drugs or chemicals that affect the inner ear. Ototoxic drugs can impair hearing, balance, or both.
Mechanism Description		Increased risk of ototoxicity by the combination of Gentamicin (topical) and Kanamycin

Recommended Action
Management		Topical preparations containing an aminoglycoside should not be used with other aminoglycosides in circumstances where significant systemic absorption could occur (e.g., application to burnt or broken skin use of large quantities or on large areas for prolonged periods). The normally recommended dosages of these products should not be exceeded.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".