Details of Drug

Drug General Information (ID: D0668)
Drug Name	Flucytosine
Drug Type	Small molecule
Drug Synonymous	Alcobon; Ancobon; Ancotil; Ancotyl; Flucitosina; Flucystine; Flucytosin; Flucytosinum; Flucytosone; Fluocytosine; Fluorcytosine; Fluorocytosine; Flucitosina [DCIT]; F0321; LT00771985; Ancobon (TN); Flucytosinum [INN-Latin]; GL663142 & 5FC; Ro 2-9915; Ro 29915 E/265601; Ro-2-9915; Flucytosine (JP15/USP/INN); Flucytosine [USAN:INN:BAN:JAN]; Cytosine, 5-fluoro-(6CI,7CI,8CI); GL663142 & 4-Amino-5-fluoropyrimidin-2(1H)-one; 2(1H)-Pyrimidinone, 4-amino-5-fluoro-); 2-Hydroxy-4-amino-5-fluoropyrimidine; 4-Amino-5-fluoro-2(1H)-pyrimidinone; 4-Amino-5-fluoro-2-hydroxypyrimidine; 4-Amino-5-fluoro-2-hyroxypyrimidine; 4-Amino-5-fluoropyrimidin-2(1H)-one; 5-FC; 5-Flucytosine; 5-Fluorocystosine; 5-Fluorocytosin; 5-Fluorocytosine; 5-Fluorocytosine-6-3H; 5-Flurocytosine; 5-fluoro cytosine; 5987P; 6-Amino-2-oxo-5-fluoropyrimidine; 6-amino-5-fluoro-1H-pyrimidin-2-one; 9074P Click to Show/Hide
Disease Class	BB40-BA42: Endocarditis
Therapeutic Class	Antifungal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C4H4FN3O
InChI	1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
InChIKey	XRECTZIEBJDKEO-UHFFFAOYSA-N
Canonical SMILES	C1=NC(=O)NC(=C1F)N
External Link
	Pubchem ID	3366
	CAS Number	2022-85-7
	CHEBI ID	5100
	TTD ID	D0S5WG
	INTEDE ID	DR2287

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM027 Decreased renal excretion due to nephrotoxicity BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM072 Increased risk of nephrotoxicity
Relation Graph

Full list of drugs interacting with Flucytosine
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 66
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[9]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[9]
D0142		Bacitracin	C66H103N17O16S	10909430	Moderate		Inter Info	[9]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[9]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[9]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[9]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[9]
D0335		Cidofovir	C8H14N3O6P	60613	Moderate		Inter Info	[9]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[9]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[9]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[9]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[9]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[9]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[9]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[9]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Moderate		Inter Info	[9]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[9]
D0709		Gallium nitrate	GaN3O9	61635	Moderate		Inter Info	[9]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[9]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Moderate		Inter Info	[9]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[9]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[9]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[9]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[9]
D1091		Moxetumomab Pasudotox	NA	NA	Moderate		Inter Info	[9]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[9]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[9]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[9]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[9]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[9]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[9]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[9]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[9]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[9]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[9]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[9]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[9]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[9]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[9]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[9]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[9]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[9]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[9]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[9]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[9]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[9]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[9]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[9]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[9]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[9]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[9]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[9]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[9]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[9]
D1310		Polymyxin B	C56H98N16O13	49800004	Moderate		Inter Info	[9]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[9]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[9]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[9]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[9]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[9]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[9]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[9]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[9]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[9]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[9]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[9]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[10]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[12]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[13]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[5], [1], [14]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[15]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[5], [1], [18]
	Additive myelosuppressive effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [2]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [3], [4]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[5], [6], [7]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[8]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[5], [1]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[11]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[5], [1], [16], [17]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[5], [1], [16], [17]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
3	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
4	Canadian Pharmacists Association "e-CPS."
5	Cerner Multum, Inc. "Australian Product Information.".
6	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
7	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
8	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
9	Product Information. Ancobon (flucytosine). Roche Laboratories, Nutley, NJ.
10	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
11	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
12	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
13	AnazaoHealth Corporation "P32 Sodium Phosphate."
14	Multum Information Services, Inc. Expert Review Panel.
15	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
16	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
17	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
18	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.

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