Details of Drug | MecDDI

Drug General Information (ID: D0654)
Drug Name		Ferumoxytol
Drug Type		Small molecule
Drug Synonymous		MAGNETITE; Magnetic oxide; Ferrosoferric oxide; Magnetite (Fe3O4); Magnetic Black; Iron Black; Fenosoferric oxide; Black Iron BM; Meramec M 25; Black Gold F 89; RB-BL; 11557 Black; CCRIS 4376; H 3S; EPT 500; EINECS 215-169-8; KN 320; 1309-38-2; iron(ii; ferro ferric oxide; ferric ferrous oxide; Iron ores, magnetite; Ferumoxytol [USAN]; Eisen(II,III)-oxid; KBC 100 (mineral); Code 7228; CHEBI:50821; 1317-61-9 (Parent); LS-88610; 174794-75-3; 122303-97-3; 90577-09-6; 73904-98-0; 151820-32-5; 137263-94-6; 124364-57-4 Click to Show/Hide
Disease Class		GB61: Chronic kidney disease
Therapeutic Class		Iron Supplement
Structure
Structure		3D Structure				2D Structure
Formula		Fe3H2O4
InChI		1S/3Fe.2H2O.2O/h;;;21H2;;/q;2+1;;;;/p-2
InChIKey		UCNNJGDEJXIUCC-UHFFFAOYSA-L
Canonical SMILES		O[Fe]=O.O[Fe]=O.[Fe]
External Link
		Pubchem ID		14789
		CAS Number		1309-38-2
		CHEBI ID		50821
		TTD ID		D06CTM

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM013 Competitive binding of plasma proteins BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Ferumoxytol
Affected gastrointestinal absorption
					Altered absorption (Unspecific)																																																																Drug Num: 5
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0649															Ferrous fumarate															C4H2FeO4															6433164															Moderate															Inter Info													[7], [8], [9], [10], [11]
D0650															Ferrous gluconate															C12H22FeO14															23616740															Moderate															Inter Info													[7], [8], [9], [10], [11]
D0651															Ferrous sulfate anhydrous															FeO4S															24393															Moderate															Inter Info													[8], [10], [11]
D0849															Iron protein succinylate															NA															NA															Moderate															Inter Info													[7], [8], [9], [10], [11]
D0847															Iron															Fe															23925															Moderate															Inter Info													[8], [10], [11]
Affected organization distribution
					Competitive binding of plasma proteins																																																																Drug Num: 1
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0708															Gallium chloride Ga-67															Cl3Ga															73415785															Moderate															Inter Info													[12]
Pharmacodynamic antagonistic effects
					Attenuated pharmacological effects (Unspecific)																																																																Drug Num: 3
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D1776															Dimercaprol															C3H8OS2															3080															Major															Inter Info													[1], [2], [3]
D0313															Chloramphenicol															C11H12Cl2N2O5															5959															Moderate															Inter Info													[4], [5], [6]
D1703															Vitamin E															C29H50O2															14985															Moderate															Inter Info													[13], [14]

References
1	Desmedt S, Spinewine A, Jadoul M, Henrard S, Wouters D, Dalleur O. Impact of a clinical decision support system for drug dosage in patients with renal failure.?Int J Clin Pharm. 2018;40(5):1225-1233. [PMID: 29785684]
2	Chenoweth MB "Clinical uses of metal-binding drugs." Clin Pharmacol Ther 9 (1968): 365-87. [PMID: 4984845]
3	Product Information. BAL in Oil (dimercaprol). Becton Dickinson, Franklin Lakes, NJ.
4	Saidi P, Wallerstein RO, Aggeler PM "Effect of chloramphenicol on erythropoiesis." J Lab Clin Med 57 (1961): 247-56
5	Haile CA "Chloramphenicol toxicity." South Med J 70 (1977): 479-80
6	Scott JL, Finegold SY, Belkin GA, Lawrence JS "A controlled double-blind study of the hematologic toxicity of chloramphenicol." N Engl J Med 272 (1965): 1137-42
7	Product Information. Accrufer (ferric maltol). Shield Therapeutics, Wilmington, DE.
8	Product Information. Feraheme (ferumoxytol). Alza Pharmaceuticals, Mountain View, CA.
9	Product Information. Ferrlecit (sodium ferric gluconate complex). sanofi-aventis, Bridgewater, NJ.
10	Product Information. INFeD (iron dextran). Schein Pharmaceuticals Inc, Florham Park, NJ.
11	Product Information. Venofer (iron sucrose) American Regent Laboratories Inc, Shirley, NY.
12	Product Information. Gallium Citrate Ga-67 (gallium citrate 67 Ga (gallium citrate 67Ga)). Bristol-Myers Squibb, Princeton, NJ.
13	Graeber JE, Williams ML, Oski FA "The use of intramuscular vitamin E in the premature infant. Optimum dose and iron interaction." J Pediatr 90 (1977): 282-4
14	Melhorn DK, Gross S "Relationships between iron-dextran and vitamin E in iron deficiency anemia in children." J Lab Clin Med 74 (1969): 789-802