Drug General Information (ID: DDI3BT1W7Z)
Drug Name			Ferumoxytol		Drug Info		Dimercaprol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Iron Supplement				Antidotes
Structure

Mechanism of Ferumoxytol-Dimercaprol Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Ferumoxytol				Dimercaprol
Mechanism		Iron parenteral				Heavy metal chelator
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Dimercaprol when combined with Ferumoxytol

Recommended Action
Management		Preparations containing iron or selenium salts should not be administered during chelation therapy with dimercaprol and for at least 24 hours after the last dose of dimercaprol.

References
1	Desmedt S, Spinewine A, Jadoul M, Henrard S, Wouters D, Dalleur O. Impact of a clinical decision support system for drug dosage in patients with renal failure.?Int J Clin Pharm. 2018;40(5):1225-1233. [PMID: 29785684]
2	Chenoweth MB "Clinical uses of metal-binding drugs." Clin Pharmacol Ther 9 (1968): 365-87. [PMID: 4984845]
3	Product Information. BAL in Oil (dimercaprol). Becton Dickinson, Franklin Lakes, NJ.