Drug General Information (ID: DDIM5RXG0D)
Drug Name			Ferumoxytol		Drug Info		Gallium chloride Ga-67		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Iron Supplement				Diagnostic Radiopharmaceuticals
Structure

Mechanism of Ferumoxytol-Gallium chloride Ga-67 Interaction (Severity Level: Moderate)
Competitive binding of plasma proteins Click to Show/Hide Mechanism Graph
Drug Name		Ferumoxytol				Gallium chloride Ga-67
Mechanism		Competition for plasma protein binding sites				Competition for plasma protein binding sites
Key Mechanism Factor 1
		Factor Name		Plasma protein binding
		Factor Description		Plasma protein binding refers to the degree of binding of a drug to proteins in the blood, and the lower the degree of binding, the more efficiently the drug can cross cell membranes or diffuse. Plasma protein binding alters the distribution and therapeutic characteristics of the drugs.
Mechanism Description		Increased plasma concentration of Gallium chloride Ga-67 and Ferumoxytol due to competitive binding of plasma proteins

Recommended Action
Management		Clinicians should be aware of possible interference with diagnostic tests in patients who are taking these medications.

References
1	Product Information. Gallium Citrate Ga-67 (gallium citrate 67 Ga (gallium citrate 67Ga)). Bristol-Myers Squibb, Princeton, NJ.