Details of Drug

Drug General Information (ID: D0576)
Drug Name	Entecavir
Drug Type	Small molecule
Drug Synonymous	Baraclude; ETV; Entecavir hydrate; Entecavir monohydrate; BMS-200475; Baraclude (TN); Entecavir (INN); Entecavir (USAN); Entecavir hydrate (JAN); SQ-34676; 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one; 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one; 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one-water (1/1); 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one; 6-H-Purin-6-one-,2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]; 9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)guanine monohydrate Click to Show/Hide
Disease Class	1E50-1E51: Hepatitis virus infection
Therapeutic Class	Antiviral Agents
Structure
Structure	3D Structure		2D Structure
Formula	C12H15N5O3
InChI	1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1
InChIKey	QDGZDCVAUDNJFG-FXQIFTODSA-N
Canonical SMILES	C=C1C(CC(C1CO)O)N2C=NC3=C2N=C(NC3=O)N
External Link
	Pubchem ID	135398508
	CAS Number	142217-69-4
	CHEBI ID	473990
	TTD ID	D0KR2J
	VARIDT ID	DR01277

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM005 Affected excretion pathways AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM027 Decreased renal excretion due to nephrotoxicity BM028 Competitive inhibition of renal tubular secretion BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Entecavir
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[5]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 67
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[1]
D0335		Cidofovir	C8H14N3O6P	60613	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[1]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[1]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[1]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[1]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[1]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[1]
D0142		Bacitracin	C66H103N17O16S	10909430	Moderate		Inter Info	[1]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[1]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[1]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[1]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[1]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Moderate		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[1]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[1]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[1]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[1]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[1]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[1]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[1]
D0709		Gallium nitrate	GaN3O9	61635	Moderate		Inter Info	[1]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[1]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[1]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[1]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Moderate		Inter Info	[1]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[1]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[1]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[1]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[1]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[1]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[1]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[1]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[1]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[1]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[1]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[1]
D1091		Moxetumomab Pasudotox	NA	NA	Moderate		Inter Info	[1]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[1]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[1]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[1]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[1]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[1]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[1]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[1]
D1310		Polymyxin B	C56H98N16O13	49800004	Moderate		Inter Info	[1]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[1]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[1]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[1]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[1]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[1]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[1]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[1]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[1]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[1]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[1]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[1]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[1]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[1]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[1]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[1]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[1]
	Competitive inhibition of renal tubular secretion					Drug Num: 80
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0040		Allopurinol	C5H4N4O	135401907	Moderate		Inter Info	[1]
D0065		Aminosalicylic acid	C7H7NO3	4649	Moderate		Inter Info	[1]
D0079		Ampicillin	C16H19N3O4S	6249	Moderate		Inter Info	[1]
D0140		Aztreonam	C13H17N5O8S2	5742832	Moderate		Inter Info	[1]
D0282		Cefmetazole	C15H17N7O5S3	42008	Moderate		Inter Info	[1]
D1768		Creatine	C4H9N3O2	586	Moderate		Inter Info	[1]
D0022		Acyclovir	C8H11N5O3	135398513	Moderate		Inter Info	[1]
D0073		Amoxicillin	C16H19N3O5S	33613	Moderate		Inter Info	[1]
D0141		Bacampicillin	C21H27N3O7S	441397	Moderate		Inter Info	[1]
D0167		Benzylpenicillin	C16H18N2O4S	5904	Moderate		Inter Info	[1]
D0168		Benzylpenicillin (potassium)	C16H18N2O4S	5904	Moderate		Inter Info	[1]
D0169		Benzylpenicillin (sodium)	C16H18N2O4S	5904	Moderate		Inter Info	[1]
D0257		Carbenicillin	C17H18N2O6S	20824	Moderate		Inter Info	[1]
D0271		Cefaclor	C15H14ClN3O4S	51039	Moderate		Inter Info	[1]
D0272		Cefadroxil	C16H17N3O5S	47965	Moderate		Inter Info	[1]
D0273		Cefalotin	C16H16N2O6S2	6024	Moderate		Inter Info	[1]
D0274		Cefamandole	C18H18N6O5S2	456255	Moderate		Inter Info	[1]
D0275		Cefapirin	C17H17N3O6S2	30699	Moderate		Inter Info	[1]
D0276		Cefazolin	C14H14N8O4S3	33255	Moderate		Inter Info	[1]
D0277		Cefdinir	C14H13N5O5S2	6915944	Moderate		Inter Info	[1]
D0278		Cefditoren	C19H18N6O5S3	9870843	Moderate		Inter Info	[1]
D0281		Cefixime	C16H15N5O7S2	5362065	Moderate		Inter Info	[1]
D0283		Cefonicid	C18H18N6O8S3	43594	Moderate		Inter Info	[1]
D0284		Cefoperazone	C25H27N9O8S2	44187	Moderate		Inter Info	[1]
D0285		Cefotaxime	C16H17N5O7S2	5742673	Moderate		Inter Info	[1]
D0287		Cefoxitin	C16H17N3O7S2	441199	Moderate		Inter Info	[1]
D0288		Cefpodoxime	C15H17N5O6S2	6335986	Moderate		Inter Info	[1]
D0289		Cefprozil	C18H19N3O5S	5281006	Moderate		Inter Info	[1]
D0290		Cefradine	C16H19N3O4S	38103	Moderate		Inter Info	[1]
D0294		Ceftizoxime	C13H13N5O5S2	6533629	Moderate		Inter Info	[1]
D0297		Cefuroxime	C16H16N4O8S	5479529	Moderate		Inter Info	[1]
D0301		Cephalexin	C16H17N3O4S	27447	Moderate		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1]
D0369		Cloxacillin	C19H18ClN3O5S	6098	Moderate		Inter Info	[1]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[1]
D0480		Dicloxacillin	C19H17Cl2N3O5S	18381	Moderate		Inter Info	[1]
D0519		Doripenem	C15H24N4O6S2	73303	Moderate		Inter Info	[1]
D0544		Dyphylline	C10H14N4O4	3182	Moderate		Inter Info	[1]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[1]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[1]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[1]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[1]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[1]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[1]
D0794		Imipenem	C12H17N3O4S	104838	Moderate		Inter Info	[1]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[1]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[1]
D0949		Loracarbef	C16H16ClN3O4	5284585	Moderate		Inter Info	[1]
D1008		Meropenem	C17H25N3O5S	441130	Moderate		Inter Info	[1]
D1044		Meticillin	C17H20N2O6S	6087	Moderate		Inter Info	[1]
D1055		Mezlocillin	C21H25N5O8S2	656511	Moderate		Inter Info	[1]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[1]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[1]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[1]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[1]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[1]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[1]
D1192		Oxacillin	C19H19N3O5S	6196	Moderate		Inter Info	[1]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[1]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[1]
D1341		Probenecid	C13H19NO4S	4911	Moderate		Inter Info	[1]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[1]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[1]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[1]
D1898		Tazobactam	C10H12N4O5S	123630	Moderate		Inter Info	[1]
D1580		Ticarcillin	C15H16N2O6S2	36921	Moderate		Inter Info	[1]
D1672		Valaciclovir	C13H20N6O4	135398742	Moderate		Inter Info	[1]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[1]
D0596		Ertapenem	C22H25N3O7S	150610	Moderate		Inter Info	[1]
D0635		Famciclovir	C14H19N5O4	3324	Moderate		Inter Info	[1]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[1]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[1]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[1]
D1851		Oseltamivir	C16H28N2O4	65028	Moderate		Inter Info	[1]
D1268		Phenoxymethylpenicillin	C16H18N2O5S	6869	Moderate		Inter Info	[1]
D1296		Piperacillin	C23H27N5O7S	43672	Moderate		Inter Info	[1]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[1]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[2], [3], [4]

References
1	Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
4	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
5	MHRA. Medicines and Healthcare Products Regulatory Agency "Orlistat: theoretical interaction with antiretroviral HIV medicines.".

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