Drug General Information (ID: DDI6YEOGDL)
Drug Name			Ampicillin		Drug Info		Entecavir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antiviral Agents
Structure

Mechanism of Ampicillin-Entecavir Interaction (Severity Level: Moderate)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Ampicillin				Entecavir
Mechanism		Competitive inhibition of renal tubular secretion of entecavir				Entecavir
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Entecavir caused by Ampicillin mediated competitive inhibition of renal tubular secretion

Recommended Action
Management		Patients receiving entecavir with another drug that undergoes active tubular secretion should be monitored for excessive pharmacologic effects of both drugs, and the dosages adjusted as necessary.

References
1	Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.