Details of Drug

Drug General Information (ID: D0568)
Drug Name	Enasidenib
Drug Type	Small molecule
Drug Synonymous	AG-221 (IDH2 inhibitor) Click to Show/Hide
Disease Class	2A60: Acute myeloid leukaemia; 2A41: BCR-ABL1-negative chronic myeloid leukaemia
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C19H17F6N7O
InChI	1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32)
InChIKey	DYLUUSLLRIQKOE-UHFFFAOYSA-N
Canonical SMILES	CC(C)(CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F)O
External Link
	Pubchem ID	89683805
	CAS Number	1446502-11-9
	CHEBI ID	145374
	TTD ID	D0K7FT
	INTEDE ID	DR0574

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction
Relation Graph

Full list of drugs interacting with Enasidenib
Affected cellular transport
	Transporter inhibition					Drug Num: 57
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[1], [2], [3]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Major		Inter Info	[4], [5]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[4], [5]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[4], [5]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[4], [5]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[4], [5]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[4], [5]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[4], [5], [6]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[4], [5]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[4], [5]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[4], [5]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[4], [5], [6]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[4], [5]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[4], [5]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[4], [5], [6]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[4], [5]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[4], [5]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[4], [5], [6]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[4], [5]
D0631		Ezetimibe	C24H21F2NO3	150311	Moderate		Inter Info	[4], [5]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[4], [5]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[4], [5]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[4], [5]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[4], [5], [6]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[4], [5]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[4], [5]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[4], [5]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[4], [5], [6]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[4], [5]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[4], [5]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[4], [5], [6]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[4], [5]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[4], [5]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[4], [5]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[4], [5]
D1227		Paritaprevir	C40H43N7O7S	45110509	Moderate		Inter Info	[4], [5], [6]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[4], [5]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[4], [5]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[4], [5]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[4], [5]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[4], [5]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[4], [5], [6]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[4], [5]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[4], [5]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[4], [5]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[4], [5]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[4], [5]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[4], [5], [6]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[4], [5]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[4], [5]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[4], [5], [6]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[4], [5]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[4], [5]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[4], [5]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[4], [5]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[4], [5]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0485		Dienogest	C20H25NO2	68861	Moderate		Inter Info	[7], [8], [5]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[5]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[7], [8], [5]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[5]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[5]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[7], [8], [5]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[7], [8], [5]
D1156		Norgestimate	C23H31NO3	6540478	Moderate		Inter Info	[7], [8], [5]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[7], [8], [5]

References
1	Ace LN, Jaffe JM, Kunka RL "Effect of food and an antacid on quinidine bioavailability." Biopharm Drug Dispos 4 (1983): 183-90. [PMID: 6882885]
2	Min DI, Ku YM, Geraets DR, Lee HC "Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers." J Clin Pharmacol 36 (1996): 469-76. [PMID: 8739026]
3	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
4	Cerner Multum, Inc. "Australian Product Information.".
5	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
6	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
7	Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
8	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence