Details of Drug

Drug General Information (ID: D0536)
Drug Name	Drospirenone
Drug Type	Small molecule
Drug Synonymous	DRSP; Dehydrospirorenone; Dihydrospirorenone; Drospirenona; Drospirenonum; Drospirenone [INN]; ZK 30595; ZK30595; Angeliq, Drospirenone; Drospirenona [INN-Spanish]; Drospirenonum [INN-Latin]; SH-470; ZK-30595; Drospirenone (JAN/USAN/INN); (6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-1,3',4',6,6a,7,8,9,10,11,12,13,14,15,15a,16-Hexadecahydro-10,13-dimethylspiro-(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(2H)-dione; 1,2-Dihydrospirorenone; 1,2-dihydro-spirorenone; 17-Hydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid, gamma-lactone; 3-oxo-6alpha,7alpha,15alpha,16alpha-tetrahydro-7'H,16'H-dicyclopropa[6,7;15,16]-17alpha-pregn-4-ene-21,17-carbolactone; 6-beta,7-beta;15-beta,16-beta-Dimethylene-3-oxo-17-alpha-pregn-4-ene-21,17-carbolactone; 6beta,7beta,15beta,16beta-dimethylen-3-oxo-17alpha-pregn-4-en-21,17-carbolacton; 6beta,7beta,15beta,16beta-dimethylene-3-oxo-17alpha-pregn-4-ene-21,17 carbolactone; 6beta,7beta;15beta,16beta-Dimethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone; Spiro(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(2H)-dione, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-, (6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17beta Click to Show/Hide
Disease Class	QA21: Contraceptive management
Therapeutic Class	Contraceptive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C24H30O3
InChI	1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1
InChIKey	METQSPRSQINEEU-HXCATZOESA-N
Canonical SMILES	CC12CCC(=O)C=C1C3CC3C4C2CCC5(C4C6CC6C57CCC(=O)O7)C
External Link
	Pubchem ID	68873
	CAS Number	67392-87-4
	CHEBI ID	50838
	TTD ID	D0Z4ZT
	INTEDE ID	DR0551
	VARIDT ID	DR00825

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM009 Altered absorption (Unspecific) BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM020 Decreased metabolism due to hepatotoxicity BM022 CYP450 enzyme induction BM023 UGT induction BM025 Decreased metabolism (Unspecific) BM047 Additive thrombogenic effects BM058 Increased risk of hyperkalemia BM079 Increased risk of skin rash BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Drospirenone
Affected gastrointestinal absorption
	Complex formation					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[150]
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[151], [152], [1], [153], [154], [155], [156]
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[151], [152], [1], [153], [154], [155], [156]
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1068		Miltefosine	C21H46NO4P	3599	Moderate		Inter Info	[180]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[124], [126], [131]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[2], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
	CYP450 enzyme inhibition					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[107], [108], [109], [110], [111], [112], [113]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[145], [146], [147], [148], [149], [63]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[157]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[163]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[171]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1], [2], [174]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[175]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[1], [2], [177]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[178]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[179]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[186]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[145], [146], [147], [148], [149], [63]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[194]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[145], [146], [147], [148], [149], [63]
D0120		Atorvastatin	C33H35FN2O5	60823	Minor		Inter Info	[209]
	Decreased metabolism due to hepatotoxicity					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[1], [2], [143]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[1], [2], [143]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[1], [2], [143]
	CYP450 enzyme induction					Drug Num: 61
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[8], [9]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[8], [10]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [8], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[43]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[8], [44]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[45]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [8], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[2], [46], [47]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[48]
D0639		Felbamate	C11H14N2O4	3331	Major		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [8], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [8], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0741		Griseofulvin	C17H17ClO6	441140	Major		Inter Info	[14], [54], [55], [56], [8], [22], [57], [58], [59], [60], [61], [62], [63]
D1198		Oxcarbazepine	C15H12N2O2	34312	Major		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [8], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [8], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [8], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [8], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[68], [11], [69], [70], [71], [13], [15], [72], [73], [74], [75], [76], [18], [77], [56], [20], [8], [22], [78], [79], [80], [81], [82], [83], [84], [85], [86], [41], [87], [61], [63], [88]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[70], [83], [87]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[68], [11], [69], [70], [71], [13], [15], [72], [73], [74], [75], [76], [18], [77], [56], [20], [8], [22], [78], [79], [80], [81], [82], [83], [84], [85], [86], [41], [87], [61], [63], [88]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[89], [90], [91], [8], [22], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[11], [69], [12], [71], [13], [15], [72], [74], [75], [55], [16], [17], [135], [18], [56], [20], [90], [8], [23], [93], [94], [136], [25], [27], [28], [79], [29], [58], [80], [137], [81], [30], [99], [138], [101], [85], [86], [41], [103], [60], [87], [61], [62], [63], [42], [88], [139]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [135], [18], [20], [8], [23], [24], [140], [28], [29], [137], [31], [35], [40], [41]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[8], [141], [142]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [135], [18], [20], [8], [23], [24], [140], [28], [29], [137], [31], [35], [40], [41]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [135], [18], [20], [8], [23], [24], [140], [28], [29], [137], [31], [35], [40], [41]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[8], [144]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[11], [69], [12], [71], [13], [15], [72], [74], [75], [55], [16], [17], [135], [18], [56], [20], [90], [8], [23], [93], [94], [136], [25], [27], [28], [79], [29], [58], [80], [137], [81], [30], [99], [138], [101], [85], [86], [41], [103], [60], [87], [61], [62], [63], [42], [88], [139]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1], [8], [158], [159], [160], [161]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[46], [64], [162]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[11], [69], [12], [71], [13], [15], [72], [74], [75], [55], [16], [17], [135], [18], [56], [20], [90], [8], [23], [93], [94], [136], [25], [27], [28], [79], [29], [58], [80], [137], [81], [30], [99], [138], [101], [85], [86], [41], [103], [60], [87], [61], [62], [63], [42], [88], [139]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[168]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[11], [69], [12], [71], [13], [15], [72], [74], [75], [55], [16], [17], [135], [18], [56], [20], [90], [8], [23], [93], [94], [136], [25], [27], [28], [79], [29], [58], [80], [137], [81], [30], [99], [138], [101], [85], [86], [41], [103], [60], [87], [61], [62], [63], [42], [88], [139]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[170]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[11], [69], [12], [71], [13], [15], [72], [74], [75], [55], [16], [17], [135], [18], [56], [20], [90], [8], [23], [93], [94], [136], [25], [27], [28], [79], [29], [58], [80], [137], [81], [30], [99], [138], [101], [85], [86], [41], [103], [60], [87], [61], [62], [63], [42], [88], [139]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[8], [141], [142]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[2], [172]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[173]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[13], [56], [60]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[176]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[11], [69], [12], [71], [13], [15], [72], [74], [75], [55], [16], [17], [135], [18], [56], [20], [90], [8], [23], [93], [94], [136], [25], [27], [28], [79], [29], [58], [80], [137], [81], [30], [99], [138], [101], [85], [86], [41], [103], [60], [87], [61], [62], [63], [42], [88], [139]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[2], [8]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[1], [2], [8], [182], [34]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[2], [8], [183]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1], [2], [8], [182], [34]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1], [2], [184]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1], [2], [185], [184]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[187]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[11], [69], [12], [71], [13], [15], [72], [74], [75], [55], [16], [17], [135], [18], [56], [20], [90], [8], [23], [93], [94], [136], [25], [27], [28], [79], [29], [58], [80], [137], [81], [30], [99], [138], [101], [85], [86], [41], [103], [60], [87], [61], [62], [63], [42], [88], [139]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[2], [8], [190], [191]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[13], [31], [35]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[11], [69], [12], [71], [13], [15], [72], [74], [75], [55], [16], [17], [135], [18], [56], [20], [90], [8], [23], [93], [94], [136], [25], [27], [28], [79], [29], [58], [80], [137], [81], [30], [99], [138], [101], [85], [86], [41], [103], [60], [87], [61], [62], [63], [42], [88], [139]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[1], [8], [158], [159], [160], [161]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[11], [69], [12], [71], [13], [15], [72], [74], [75], [55], [16], [17], [135], [18], [56], [20], [90], [8], [23], [93], [94], [136], [25], [27], [28], [79], [29], [58], [80], [137], [81], [30], [99], [138], [101], [85], [86], [41], [103], [60], [87], [61], [62], [63], [42], [88], [139]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[197], [8], [198]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [135], [18], [20], [8], [23], [24], [140], [28], [29], [137], [31], [35], [40], [41]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [135], [18], [20], [8], [23], [24], [140], [28], [29], [137], [31], [35], [40], [41]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1], [2], [184]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[11], [69], [12], [71], [13], [15], [72], [74], [75], [55], [16], [17], [135], [18], [56], [20], [90], [8], [23], [93], [94], [136], [25], [27], [28], [79], [29], [58], [80], [137], [81], [30], [99], [138], [101], [85], [86], [41], [103], [60], [87], [61], [62], [63], [42], [88], [139]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[22], [202], [203], [204]
D0208		Brivaracetam	C11H20N2O2	9837243	Minor		Inter Info	[2], [210], [211], [212]
D1294		Pioglitazone	C19H20N2O3S	4829	Minor		Inter Info	[213], [202], [214], [215], [216]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[205], [206], [207], [208]
	Decreased metabolism (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[199], [200], [201]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[199], [200], [201]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[2], [8]
D1312		Pomalidomide	C13H11N3O4	134780	Major		Inter Info	[49], [50], [51]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[2], [64], [65]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[2], [64], [106]
D1619		Tranexamic acid	C8H15NO2	5526	Major		Inter Info	[114], [115], [116]
D0385		Conestat alfa	NA	NA	Moderate		Inter Info	[164], [165], [166], [167]
D0762		Human C1-esterase inhibitor	NA	NA	Moderate		Inter Info	[164], [166], [167]
	Increased risk of hyperkalemia					Drug Num: 57
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[120], [7]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[7], [120]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[7], [120]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[7], [120]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[7], [120]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[7], [120]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[7], [120]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[7], [120]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[7], [120]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[7], [120]
D1086		Monopotassium phosphate	H2KO4P	516951	Moderate		Inter Info	[120], [7]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[120], [7]
D1316		Potassium acetate	C2H3KO2	517044	Moderate		Inter Info	[7], [120]
D1317		Potassium bicarbonate	CHKO3	516893	Moderate		Inter Info	[7], [120]
D1319		Potassium citrate	C6H5K3O7	13344	Moderate		Inter Info	[7], [120]
D1320		Potassium gluconate	C6H11KO7	16760467	Moderate		Inter Info	[7], [120]
D1322		Potassium perchlorate	ClKO4	516900	Moderate		Inter Info	[7], [120]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[7], [120]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[188]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[7], [120]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[7], [120]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[7], [120]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[7], [120]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[7], [120]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[7], [120]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[7], [120]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[7], [120]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[7], [120]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[7], [120]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[7], [120]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[7], [120]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[120], [7]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[7], [120]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[7], [120]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[7], [120]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[7], [120]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[7], [120]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[7], [120]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[7], [120]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[7], [120]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[7], [120]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[7], [120]
D1318		Potassium chloride	ClK	4873	Moderate		Inter Info	[7], [120]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[7], [120]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[7], [120]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[7], [120]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[120], [7]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[7], [120]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[7], [120]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[7], [120]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[7], [120]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[7], [120]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[7], [120]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[7], [120]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[7], [120]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[7], [120]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[7], [120]
	Increased risk of skin rash					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0558		Elexacaftor	C26H34F3N7O4S	134587348	Moderate		Inter Info	[2], [64], [169]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[117], [118], [119]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[117], [118], [119]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[117], [118], [119]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[117], [118], [119]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[117], [118], [119]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[117], [118], [119]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[117], [118], [119]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[117], [118], [119]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[117], [118], [119]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[117], [118], [119]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[117], [118], [119]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[117], [118], [119]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[117], [118], [119]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[117], [118], [119]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[117], [118], [119]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[117], [118], [119]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[117], [118], [119]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[117], [118], [119]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[117], [118], [119]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[117], [118], [119]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[117], [118], [119]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[117], [118], [119]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[117], [118], [119]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[117], [118], [119]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[117], [118], [119]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[117], [118], [119]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[117], [118], [119]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[117], [118], [119]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[117], [118], [119]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[117], [118], [119]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[117], [118], [119]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[117], [118], [119]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[117], [118], [119]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[117], [118], [119]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[117], [118], [119]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[117], [118], [119]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[117], [118], [119]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[117], [118], [119]
	Antagonize the effect of antihypertensive agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[117], [118], [119]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[117], [118], [119]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[117], [118], [119]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1894		Sugammadex	C72H112O48S8	6918585	Major		Inter Info	[2], [52], [53]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[64], [66], [67]
D1095		Mycophenolic acid	C17H20O6	446541	Major		Inter Info	[64], [66], [67]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[181], [1]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[2], [189], [52]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[42], [192], [193]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[195], [64], [196]

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165	Product Information. Cinryze (complement C1 esterase inhibitor). ViroPharma Incorporated, Exton, PA.
166	Product Information. Ruconest (conestat alfa). Valeant Pharmaceuticals, Costa Mesa, CA.
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173	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
174	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
175	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
176	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
177	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
178	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
179	Product Information. Myalept (metreleptin). Bristol-Myers Squibb, Princeton, NJ.
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184	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
185	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
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188	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
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206	Product Information. Depacon (valproic acid). Abbott Pharmaceutical, Abbott Park, IL.
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208	Reimers A, Brodtkorb E, Sabers A. "Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations." Seizure. 2015;28:66-70.
209	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
210	Product Information. Briviact (brivaracetam). UCB Pharma Inc, Smyrna, GA.
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216	Product Information. Avandia (rosiglitazone) SmithKline Beecham, Philadelphia, PA.

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