Details of Drug

Drug General Information (ID: D0514)
Drug Name	Dolasetron
Drug Type	Small molecule
Drug Synonymous	Dolasetronum; Dolasteron; Anzemet (TN); Dolasetron (INN); Dolasetron [INN:BAN]; Dolasetronum [INN-Latin]; 3-oxooctahydro-2h-2,6-methanoquinolizin-8-yl 1h-indole-3-carboxylate Click to Show/Hide
Disease Class	MD90: Nausea/vomiting
Therapeutic Class	Antiemetics
Structure
Structure	3D Structure		2D Structure
Formula	C19H20N2O3
InChI	1S/C19H20N2O3/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17/h1-4,9,11-14,20H,5-8,10H2/t11?,12-,13+,14?
InChIKey	UKTAZPQNNNJVKR-AKJUYKBHSA-N
Canonical SMILES	C1C2CC3CC(CC1N3CC2=O)OC(=O)C4=CNC5=CC=CC=C54
External Link
	Pubchem ID	3033818
	CAS Number	115956-12-2
	CHEBI ID	94561
	TTD ID	D00YLW

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM046 Additive serotonergic effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias
Relation Graph

Full list of drugs interacting with Dolasetron
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[230]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[247]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[250]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[3], [251]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[2], [3], [252]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[4]
	CYP450 enzyme induction					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Moderate		Inter Info	[2], [248]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[2], [3], [265]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[2], [3], [266], [265]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[4]
D1399		Rifabutin	C46H62N4O11	135398743	Minor		Inter Info	[4]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[190], [191], [192]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[190], [191], [192]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[190], [191], [192]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229]
	Additive serotonergic effects					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0466		Dextromethorphan	C18H25NO	5360696	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0041		Almotriptan	C17H25N3O2S	123606	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0457		Dexfenfluramine	C12H16F3N	66265	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[2], [3], [12]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0702		Frovatriptan	C14H17N3O	77992	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1110		Naratriptan	C17H25N3O2S	4440	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1200		Oxitriptan	C11H12N2O3	439280	Major		Inter Info	[2], [3], [12]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1419		Rizatriptan	C15H19N5	5078	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1521		Sumatriptan	C14H21N3O2S	5358	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1658		Tryptophan	C11H12N2O2	6305	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1728		Zolmitriptan	C16H21N3O2	60857	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
	Increased risk of atrioventricular block					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[4]
D0117		Atenolol	C14H22N2O3	2249	Major		Inter Info	[4]
D0173		Betaxolol	C18H29NO3	2369	Major		Inter Info	[4]
D0188		Bisoprolol	C18H31NO4	2405	Major		Inter Info	[4]
D0265		Carteolol	C16H24N2O3	2583	Major		Inter Info	[4]
D0491		Digoxin	C41H64O14	2724385	Major		Inter Info	[4]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[4]
D0010		Acebutolol	C18H28N2O4	1978	Major		Inter Info	[4]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[4]
D0267		Carvedilol	C24H26N2O4	2585	Major		Inter Info	[4]
D0352		Clevidipine	C21H23Cl2NO6	153994	Major		Inter Info	[4]
D0490		Digitoxin	C41H64O13	441207	Major		Inter Info	[4]
D0640		Felodipine	C18H19Cl2NO4	3333	Major		Inter Info	[4]
D0885		Lacosamide	C13H18N2O3	219078	Major		Inter Info	[4]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Major		Inter Info	[4]
D1098		Nadolol	C17H27NO4	39147	Major		Inter Info	[4]
D1114		Nebivolol	C22H25F2NO4	71301	Major		Inter Info	[4]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[4]
D1244		Penbutolol	C18H29NO2	37464	Major		Inter Info	[4]
D1293		Pindolol	C14H20N2O2	4828	Major		Inter Info	[4]
D0602		Esmolol	C16H25NO4	59768	Major		Inter Info	[4]
D0865		Isradipine	C19H21N3O5	3784	Major		Inter Info	[4]
D0884		Labetalol	C19H24N2O3	3869	Major		Inter Info	[4]
D1049		Metoprolol	C15H25NO3	4171	Major		Inter Info	[4]
D1088		Moricizine	C22H25N3O4S	34633	Major		Inter Info	[4]
D1130		Nicardipine	C26H29N3O6	4474	Major		Inter Info	[4]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[4]
D1141		Nisoldipine	C20H24N2O6	4499	Major		Inter Info	[4]
D1357		Propranolol	C16H21NO2	4946	Major		Inter Info	[4]
D1585		Timolol	C13H24N4O3S	33624	Major		Inter Info	[4]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[4]
	Increased risk of bradycardia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[102], [231]
	Increased risk of prolong QT interval					Drug Num: 179
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0003		Abarelix	C72H95ClN14O14	16131215	Major		Inter Info	[1], [2], [3], [4]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[1], [2], [3], [4]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [15]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[13], [4], [16]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[1], [2], [3], [4]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1], [2], [3], [4]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1], [2], [3], [4]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[17], [3], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1], [2], [3], [4]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1], [2], [3], [4]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[1], [2], [3], [9], [36], [37]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3], [38], [39], [40], [12], [13], [4], [41], [14], [42]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [2], [3], [43], [44]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1], [2], [3], [4]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[2], [3], [4]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[2], [3], [4]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3], [45], [46], [47], [48], [49], [50], [51], [52], [53], [44]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3], [54]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1], [2], [3], [4]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[2], [3], [4]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3], [45], [46], [47], [48], [49], [50], [51], [52], [53], [44]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[55]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1], [2], [3], [4]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1], [2], [3], [4]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[58]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[1], [2], [3], [45], [46], [47], [48], [49], [50], [51], [52], [53], [44]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[1], [2], [3], [4]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1], [2], [3], [4]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1], [2], [3], [4]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1], [2], [3], [4]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3], [59]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1], [2], [3], [4]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3], [4]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[1], [2], [3], [4]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[60]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1], [2], [3], [4]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[1], [2], [3], [4]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[1], [2], [3], [4]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1], [2], [3], [4]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[2], [3], [4]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3], [61]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1], [2], [3], [4]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1], [2], [3], [4]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [2], [3], [38], [39], [40], [12], [13], [4], [41], [14], [42]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[1], [2], [3], [4]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[4]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[1], [2], [3], [4]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[64], [65], [66], [1], [2], [3], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[1], [2], [3], [4]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1], [2], [3], [4]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[1], [2], [3], [4]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[1], [2], [3], [4]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[87], [1], [2], [3], [88], [89], [90], [91], [92]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1], [2], [3], [4]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[1], [2], [3], [4]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[17], [3], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1], [2], [3], [4]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2], [3], [93], [44]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[99]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3], [4]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1], [2], [3], [4]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[100]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1], [2], [3], [4]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[3], [101], [44]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1], [2], [3], [4]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1], [2], [3], [4]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[2], [4], [14]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[1], [2], [3], [4]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[1], [2], [3], [4]
D0948		Lopinavir	C37H48N4O5	92727	Major		Inter Info	[4], [102], [103]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[2], [3], [104]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[105]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[1], [2], [3], [106], [44]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[1], [2], [3], [4]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1], [2], [3], [4]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2], [3], [107]
D1079		Mitoxantrone	C22H28N4O6	4212	Major		Inter Info	[1], [2], [3], [4]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1], [2], [3], [108]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[1], [2], [3], [4]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1], [2], [3], [4]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[1], [2], [3], [4]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1], [2], [3], [4]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1], [2], [3], [4]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[110]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[111], [112], [113], [114], [115], [116], [117], [118]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3], [119]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[1], [2], [3], [4]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1], [2], [3], [4]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [123], [124], [44]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[1], [2], [3], [4]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3], [4]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1], [2], [3], [4]
D1342		Probucol	C31H48O2S2	4912	Major		Inter Info	[1], [2], [3], [4]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3], [45], [46], [47], [48], [49], [50], [51], [52], [53], [44]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1], [2], [3], [4]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[4]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1], [2], [3], [4]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2], [3], [45], [46], [47], [48], [49], [50], [51], [52], [53], [44]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[1], [2], [3], [4]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2], [3], [4]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1], [2], [3], [4]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1], [2], [3], [4]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1], [2], [3], [4]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[4]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[3], [149]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2], [3], [38], [39], [40], [12], [13], [4], [41], [14], [42]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[1], [2], [3], [4]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[65], [1], [2], [3], [151], [152], [69], [71], [73], [153], [74], [75], [154], [77], [78], [79], [80], [155], [84], [156], [157]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1], [2], [3], [4]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [2], [3], [4]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3], [4]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[1], [2], [3], [4]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[1], [2], [3], [4]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[1], [2], [3], [4]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[1], [2], [3], [4]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[1], [2], [3], [4]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[1], [2], [3], [158]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[1], [2], [3], [4]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [2], [3], [159]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [2], [3], [123], [160], [44]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[161]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1], [2], [3], [4]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1], [2], [3], [4]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1], [2], [3], [4]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2], [3], [38], [39], [40], [12], [13], [4], [41], [14], [42]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1], [2], [3], [4]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[1], [2], [3], [38], [39], [40], [12], [13], [4], [41], [14], [42]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1], [2], [3], [4]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[1], [2], [3], [4]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[65], [1], [2], [3], [162], [163], [156]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3], [164], [165], [166], [167], [168], [169], [44]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1], [2], [3], [4]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2], [3], [170]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[4]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [44]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[64], [65], [66], [1], [2], [3], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1], [2], [3], [4]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1], [2], [3], [4]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[1], [2], [3], [4]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[1], [2], [3], [4]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[1], [2], [3], [38], [39], [40], [12], [13], [4], [41], [14], [42]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1], [2], [3], [4]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[181], [182]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[1], [2], [3], [4]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[1], [2], [3], [4]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1], [2], [3], [4]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1], [2], [3], [4]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3], [45], [46], [47], [48], [49], [50], [51], [52], [53], [44]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[1], [2], [3], [4]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[1], [2], [3], [4]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1], [2], [3], [183], [123], [184], [185], [186], [44]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1], [2], [3], [4]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[1], [2], [3], [187]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2], [3], [188], [12], [13], [4], [14]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[1], [2], [3], [4]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[1], [2], [3], [4]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1], [2], [3], [12], [13], [4], [14]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3], [4]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2], [3], [123], [189], [44]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[2], [3], [235], [236], [237], [238], [239], [240]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[2], [3], [249]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[253], [254]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[255], [256], [257], [258], [259], [260], [261], [262], [263], [264]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[2], [3], [268]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[2], [269], [270], [271]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[1], [2], [3], [272], [273], [274], [275]
	Increased risk of ventricular arrhythmias					Drug Num: 53
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[5], [3], [6], [7], [8], [9], [10], [11]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Major		Inter Info	[4]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Major		Inter Info	[4]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Major		Inter Info	[4]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[56], [57]
D0217		Bumetanide	C17H20N2O5S	2471	Major		Inter Info	[4]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Major		Inter Info	[4]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Major		Inter Info	[4]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[1], [2], [3], [62], [63]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Major		Inter Info	[4]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Major		Inter Info	[4]
D0798		Indapamide	C16H16ClN3O3S	3702	Major		Inter Info	[4]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[94], [95], [96]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[3], [97], [98]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[94], [95], [96]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[109]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Major		Inter Info	[120], [121], [122]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Major		Inter Info	[120], [121], [122]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Major		Inter Info	[4]
D1414		Ritodrine	C17H21NO3	33572	Major		Inter Info	[94], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [95], [143], [144], [145], [146], [96], [147], [148]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[2], [150]
D1488		Sodium sulfate	Na2O4S	24436	Major		Inter Info	[120], [121], [122]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[94], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [95], [143], [144], [145], [146], [96], [147], [148]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Major		Inter Info	[4]
D0704		Furosemide	C12H11ClN2O5S	3440	Major		Inter Info	[4]
D1048		Metolazone	C16H16ClN3O3S	4170	Major		Inter Info	[4]
D1611		Torasemide	C16H20N4O3S	41781	Major		Inter Info	[4]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[94], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [232], [233], [137], [138], [139], [140], [141], [234], [142], [95], [143], [144], [145], [146], [96], [147], [148]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[1], [2], [3], [241], [242], [243]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[1], [2], [3], [241], [242], [243]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[1], [2], [3], [244], [245], [246]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[94], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [232], [233], [137], [138], [139], [140], [141], [234], [142], [95], [143], [144], [145], [146], [96], [147], [148]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[2], [3], [243]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[1], [2], [3], [241], [242], [243]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[94], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [232], [233], [137], [138], [139], [140], [141], [234], [142], [95], [143], [144], [145], [146], [96], [147], [148]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[1], [2], [3], [241], [242], [243]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[232], [143], [146]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[1], [2], [3], [241], [242], [243]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1], [2], [3], [241], [242], [243]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[1], [2], [3], [241], [242], [243]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[94], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [232], [233], [137], [138], [139], [140], [141], [234], [142], [95], [143], [144], [145], [146], [96], [147], [148]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[1], [2], [3], [241], [242], [243]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[94], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [232], [233], [137], [138], [139], [140], [141], [234], [142], [95], [143], [144], [145], [146], [96], [147], [148]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[2], [3], [243]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[1], [2], [3], [244], [245], [246]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[129], [135], [140]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[94], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [232], [233], [137], [138], [139], [140], [141], [234], [142], [95], [143], [144], [145], [146], [96], [147], [148]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[2], [3], [267]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[232], [143], [146]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[1], [2], [3], [244], [245], [246]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[94], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [232], [233], [137], [138], [139], [140], [141], [234], [142], [95], [143], [144], [145], [146], [96], [147], [148]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[1], [2], [3], [241], [242], [243]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[1], [2], [3], [244], [245], [246]

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