Details of Drug

Drug General Information (ID: D0467)
Drug Name	Dextropropoxyphene
Drug Type	Small molecule
Drug Synonymous	Algafan; Antalvic; Destropropossifene; Dextropropoxifeno; Dextropropoxyphen; Dextropropoxyphenum; Dextroproxifeno; Femadol; Levopropoxyphene; Propoxyphene; Proxagesic; Proxyphen; Destropropossifene [DCIT]; Dextroproxifeno [Spanish]; SK 65; D-Propoxyphene; Dextropropoxifeno [INN-Spanish]; Dextropropoxyphene[INN:BAN]; Dextropropoxyphenum [INN-Latin]; Bulk dextropropoxyphene (non-dosage forms); Alpha-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate; Alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate; Alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol-propionat; Alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol-propionat [German]; Alpha-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate ester; Alpha-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-propionoxybutane; [(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate; (+)-1,2-Diphenyl-2-propionoxy-3-methyl-4-dimethylaminobutane; (+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-propionyloxybutane; (1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate; (D)-PROPOXYPHENE; (S)-alpha-(2-(Dimethylamino)-1-methylethyl)-alpha-phenylbenzeneethanol propanoate; 4-Dimethylamino-3-methyl-1,2-diphenyl-2-propoxybutane Click to Show/Hide
Disease Class	MG30-MG3Z: Pain
Therapeutic Class	Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	C22H29NO2
InChI	1S/C22H29NO2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19/h6-15,18H,5,16-17H2,1-4H3/t18-,22+/m1/s1
InChIKey	XLMALTXPSGQGBX-GCJKJVERSA-N
Canonical SMILES	CCC(=O)OC(CC1=CC=CC=C1)(C2=CC=CC=C2)C(C)CN(C)C
External Link
	Pubchem ID	10100
	CAS Number	469-62-5
	CHEBI ID	51173
	TTD ID	D0D4PB
	INTEDE ID	DR0478

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM004 Adsorption BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM035 Additive antimotility effects BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM046 Additive serotonergic effects BM049 Increased risk of atrioventricular block BM050 Increased risk of bleeding BM054 Increased risk of GI mucosal injury/bleeding risk BM064 Increased risk of hypoglycemia BM067 Increased risk of hyponatremia BM069 Increased risk of lowers seizure threshold BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM083 Potentiated the pharmacological effects (Unspecific) BM096 Antagonize the effect of opioid receptor agonists BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Dextropropoxyphene
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[7], [8], [146]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[7], [8], [146]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[7], [8], [146]
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Moderate		Inter Info	[127], [128], [129]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1840		Mebrofenin	C15H19BrN2O5	54158	Moderate		Inter Info	[182], [183], [184]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[10], [11], [12]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[31]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[78], [79], [80]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[81], [66], [82]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[109], [110], [111]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[118]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[119]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[7], [8], [61]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[26], [123], [50]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[124], [125], [126]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[139]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[7], [142], [143]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[147], [148], [149]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Moderate		Inter Info	[150]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[158], [159], [160]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[164]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[172]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[8], [174]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[185]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[124], [125], [126]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[8], [190]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[26], [193], [50]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[195], [196], [197]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[124], [125], [126]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[124], [125], [126]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[124], [125], [126]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[206]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[7], [53], [207]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[124], [125], [126]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[210], [211], [212]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[213], [214], [215]
Pharmacodynamic additive effects
	Additive antimotility effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0186		Bismuth subgallate	C7H6BiO6	16682999	Moderate		Inter Info	[8]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[8]
D0877		Kaolin	Al2H4O9Si2	56841936	Moderate		Inter Info	[8]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[8]
	Additive cardiorespiratory depression effects					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[56]
D0445		Desflurane	C3H2F6O	42113	Moderate		Inter Info	[51], [152], [153]
D0698		Fospropofol	C13H21O5P	3038498	Moderate		Inter Info	[161], [162], [163]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[51], [152], [153]
D0855		Isoflurane	C3H2ClF5O	3763	Moderate		Inter Info	[51], [152], [153]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[51], [152], [153]
D1149		Nitrous oxide	N2O	948	Moderate		Inter Info	[51], [152], [153]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[161], [162], [163]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[56]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[56]
D0570		Enflurane	C3H2ClF5O	3226	Moderate		Inter Info	[51], [152], [153]
	Additive CNS depression effects					Drug Num: 217
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Major		Inter Info	[1], [2], [3]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[4], [5], [6]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[5], [4], [6]
D0143		Baclofen	C10H12ClNO2	2284	Major		Inter Info	[1], [2], [3]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[1], [2], [3]
D0224		Butabarbital	C10H16N2O3	2479	Major		Inter Info	[1], [2], [3]
D0225		Butalbital	C11H16N2O3	2481	Major		Inter Info	[1], [2], [3]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[1], [2], [3]
D0228		Cabergoline	C26H37N5O2	54746	Major		Inter Info	[1], [2], [3]
D0263		Carisoprodol	C12H24N2O4	2576	Major		Inter Info	[1], [2], [3]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Major		Inter Info	[1], [2], [3]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[5], [16], [17]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3]
D0351		Clemastine	C21H26ClNO	26987	Major		Inter Info	[1], [2], [3]
D0356		Clobazam	C16H13ClN2O2	2789	Major		Inter Info	[1], [2], [3]
D0363		Clonidine	C9H9Cl2N3	2803	Major		Inter Info	[1], [2], [3]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Major		Inter Info	[1], [2], [3]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [2], [3]
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[1], [2], [3]
D0403		Cyproheptadine	C21H21N	2913	Major		Inter Info	[1], [2], [3]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Major		Inter Info	[1], [2], [3]
D0459		Dexmedetomidine	C13H16N2	5311068	Major		Inter Info	[1], [2], [3]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[5], [16], [17]
D0071		Amobarbital	C11H18N2O3	2164	Major		Inter Info	[1], [2], [3]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[1], [2], [3]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Major		Inter Info	[1], [2], [3]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1], [2], [3]
D0135		Azatadine	C20H22N2	19861	Major		Inter Info	[1], [2], [3]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[1], [2], [3]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[1], [2], [3]
D0208		Brivaracetam	C11H20N2O2	9837243	Major		Inter Info	[1], [2], [3]
D0212		Bromocriptine	C32H40BrN5O5	31101	Major		Inter Info	[1], [2], [3]
D0214		Brompheniramine	C16H19BrN2	6834	Major		Inter Info	[1], [2], [3]
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3]
D0248		Cannabidiol	C21H30O2	644019	Major		Inter Info	[1], [2], [3]
D0259		Carbinoxamine	C16H19ClN2O	2564	Major		Inter Info	[1], [2], [3]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[1], [2], [3]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Major		Inter Info	[1], [2], [3]
D0316		Chlorcyclizine	C18H21ClN2	2710	Major		Inter Info	[1], [2], [3]
D0318		Chlormezanone	C11H12ClNO3S	2717	Major		Inter Info	[1], [2], [3]
D0322		Chlorphenesin	C9H11ClO3	7697	Major		Inter Info	[1], [2], [3]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[5], [4], [6]
D0362		Clonazepam	C15H10ClN3O3	2802	Major		Inter Info	[1], [2], [3]
D0397		Cyclizine	C18H22N2	6726	Major		Inter Info	[1], [2], [3]
D0398		Cyclobenzaprine	C20H21N	2895	Major		Inter Info	[1], [2], [3]
D0417		Dantrolene	C14H10N4O5	6914273	Major		Inter Info	[1], [2], [3]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[5], [4], [6]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[1], [2], [3]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[1], [2], [3]
D0471		Diamorphine	C21H23NO5	5462328	Major		Inter Info	[1], [2], [3]
D0473		Diazepam	C16H13ClN2O	3016	Major		Inter Info	[1], [2], [3]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Major		Inter Info	[1], [2], [3]
D0493		Dihydrocodeine	C18H23NO3	5284543	Major		Inter Info	[1], [2], [3]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Major		Inter Info	[1], [2], [3]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[5], [4], [6]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [2], [3]
D0600		Esketamine	C13H16ClNO	182137	Major		Inter Info	[3], [2], [1]
D0604		Estazolam	C16H11ClN4	3261	Major		Inter Info	[1], [2], [3]
D0617		Ethanol	C2H6O	702	Major		Inter Info	[17]
D0621		Ethotoin	C11H12N2O2	3292	Major		Inter Info	[1], [2], [3]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[1], [2], [3]
D0639		Felbamate	C11H14N2O4	3331	Major		Inter Info	[3], [2], [1]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1], [2], [3]
D0662		Flavoxate	C24H25NO4	3354	Major		Inter Info	[1], [2], [3]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[1], [2], [3]
D0679		Flurazepam	C21H23ClFN3O	3393	Major		Inter Info	[1], [2], [3]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1], [2], [3]
D0705		Gabapentin	C9H17NO2	3446	Major		Inter Info	[33], [34], [35]
D0748		Halazepam	C17H12ClF3N2O	31640	Major		Inter Info	[1], [2], [3]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[1], [2], [3]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[3], [2], [1]
D0879		Ketamine	C13H16ClNO	3821	Major		Inter Info	[1], [2], [3]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[1], [2], [3]
D0912		Levetiracetam	C8H14N2O2	5284583	Major		Inter Info	[1], [2], [3]
D0918		Levodopa	C9H11NO4	6047	Major		Inter Info	[1], [2], [3]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[1], [2], [3]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1], [2], [3]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[1], [2], [3]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[1], [2], [3]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[1], [2], [3]
D0987		Meclizine	C25H27ClN2	4034	Major		Inter Info	[1], [2], [3]
D1006		Mepyramine	C17H23N3O	4992	Major		Inter Info	[1], [2], [3]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[5], [16], [17]
D1014		Metaxalone	C12H15NO3	15459	Major		Inter Info	[1], [2], [3]
D1019		Methdilazine	C18H20N2S	14677	Major		Inter Info	[5], [16], [17]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[16], [17], [5]
D1032		Methsuximide	C12H13NO2	6476	Major		Inter Info	[1], [2], [3]
D1040		Methylphenobarbital	C13H14N2O3	8271	Major		Inter Info	[1], [2], [3]
D1046		Metoclopramide	C14H22ClN3O2	4168	Major		Inter Info	[1], [2], [3]
D1060		Midazolam	C18H13ClFN3	4192	Major		Inter Info	[1], [2], [3]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[3], [2], [1]
D1084		Molindone	C16H24N2O2	23897	Major		Inter Info	[1], [2], [3]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[1], [2], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1], [2], [3]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Major		Inter Info	[1], [2], [3]
D1183		Opium	NA	NA	Major		Inter Info	[1], [2], [3]
D1197		Oxazepam	C15H11ClN2O2	4616	Major		Inter Info	[1], [2], [3]
D1200		Oxitriptan	C11H12N2O3	439280	Major		Inter Info	[1], [2], [3]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[1], [2], [3]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1], [2], [3]
D1224		Paraldehyde	C6H12O3	31264	Major		Inter Info	[3], [2], [1]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[1], [2], [3]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1], [2], [3]
D1255		Pergolide	C19H26N2S	47811	Major		Inter Info	[1], [2], [3]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[5], [16], [17]
D1260		Phenacemide	C9H10N2O2	4753	Major		Inter Info	[1], [2], [3]
D1264		Phenindamine	C19H19N	11291	Major		Inter Info	[1], [2], [3]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[3], [2], [1]
D1269		Phensuximide	C11H11NO2	6839	Major		Inter Info	[1], [2], [3]
D1282		Phenyltoloxamine	C17H21NO	7077	Major		Inter Info	[1], [2], [3]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1], [2], [3]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[5], [16], [17]
D1355		Propiomazine	C20H24N2OS	4940	Major		Inter Info	[5], [16], [17]
D1367		Quazepam	C17H11ClF4N2S	4999	Major		Inter Info	[1], [2], [3]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1], [2], [3]
D1378		Ramelteon	C16H21NO2	208902	Major		Inter Info	[1], [2], [3]
D1391		Remimazolam	C21H19BrN4O2	9867812	Major		Inter Info	[1], [2], [3]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1], [2], [3]
D1431		Rotigotine	C19H25NOS	59227	Major		Inter Info	[1], [2], [3]
D1433		Rufinamide	C10H8F2N4O	129228	Major		Inter Info	[1], [2], [3]
D1450		Scopolamine	C17H21NO4	3000322	Major		Inter Info	[1], [2], [3]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2], [3]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[1], [2], [3]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2], [3]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[1], [2], [3]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1], [2], [3]
D1536		Tasimelteon	C15H19NO2	10220503	Major		Inter Info	[1], [2], [3]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[3], [2], [1]
D1576		Thiothixene	C23H29N3O2S2	941651	Major		Inter Info	[1], [2], [3]
D1578		Tiagabine	C20H25NO2S2	60648	Major		Inter Info	[1], [2], [3]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1], [2], [3]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2], [3]
D1632		Triazolam	C17H12Cl2N4	5556	Major		Inter Info	[1], [2], [3]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[5], [16], [17]
D1644		Trimethobenzamide	C21H28N2O5	5577	Major		Inter Info	[1], [2], [3]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[5], [4], [6]
D1649		Tripelennamine	C16H21N3	5587	Major		Inter Info	[1], [2], [3]
D1694		Vigabatrin	C6H11NO2	5665	Major		Inter Info	[1], [2], [3]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[1], [2], [3]
D1716		Zaleplon	C17H15N5O	5719	Major		Inter Info	[3], [2], [1]
D1719		Ziconotide	C102H172N36O32S7	16135415	Major		Inter Info	[1], [2], [3]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[1], [2], [3]
D0532		Doxylamine	C17H22N2O	3162	Major		Inter Info	[1], [2], [3]
D0533		Dronabinol	C21H30O2	16078	Major		Inter Info	[1], [2], [3]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [2], [3]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[1], [2], [3]
D0575		Entacapone	C14H15N3O5	5281081	Major		Inter Info	[1], [2], [3]
D0612		Eszopiclone	C17H17ClN6O3	969472	Major		Inter Info	[1], [2], [3]
D0618		Ethchlorvynol	C7H9ClO	5281077	Major		Inter Info	[1], [2], [3]
D0620		Ethosuximide	C7H11NO2	3291	Major		Inter Info	[1], [2], [3]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2], [3]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[5], [16], [17]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[1], [2], [3]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[3], [2], [1]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1], [2], [3]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[5], [4], [6]
D0890		Lamotrigine	C9H7Cl2N5	3878	Major		Inter Info	[1], [2], [3]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[87], [88], [45]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Major		Inter Info	[1], [2], [3]
D0957		Loxapine	C18H18ClN3O	3964	Major		Inter Info	[1], [2], [3]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1], [2], [3]
D1003		Mephenytoin	C12H14N2O2	4060	Major		Inter Info	[1], [2], [3]
D1005		Meprobamate	C9H18N2O4	4064	Major		Inter Info	[1], [2], [3]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[3], [2], [1]
D1023		Methocarbamol	C11H15NO5	4107	Major		Inter Info	[1], [2], [3]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[1], [2], [3]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[1], [2], [3]
D1096		Nabilone	C24H36O3	5284592	Major		Inter Info	[1], [2], [3]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[5], [4], [6]
D1166		Olanzapine	C17H20N4S	135398745	Major		Inter Info	[1], [2], [3]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[1], [2], [3]
D1225		Paramethadione	C7H11NO3	8280	Major		Inter Info	[1], [2], [3]
D1248		Pentobarbital	C11H18N2O3	4737	Major		Inter Info	[1], [2], [3]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [2], [3]
D1325		Pramipexole	C10H17N3S	119570	Major		Inter Info	[1], [2], [3]
D1335		Pregabalin	C8H17NO2	5486971	Major		Inter Info	[33], [34], [35]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[5], [16], [17]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[5], [16], [17]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[5], [4], [6]
D1427		Ropinirole	C16H24N2O	5095	Major		Inter Info	[1], [2], [3]
D1453		Secobarbital	C12H18N2O3	5193	Major		Inter Info	[1], [2], [3]
D1547		Temazepam	C16H13ClN2O2	5391	Major		Inter Info	[1], [2], [3]
D1572		Thiethylperazine	C22H29N3S2	5440	Major		Inter Info	[5], [16], [17]
D1604		Tolcapone	C14H11NO5	4659569	Major		Inter Info	[1], [2], [3]
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[1], [2], [3]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[5], [16], [17]
D1642		Trimethadione	C6H9NO3	5576	Major		Inter Info	[1], [2], [3]
D1650		Triprolidine	C19H22N2	5282443	Major		Inter Info	[1], [2], [3]
D1677		Valproic acid	C8H16O2	3121	Major		Inter Info	[1], [2], [3]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1], [2], [3]
D1729		Zolpidem	C19H21N3O	5732	Major		Inter Info	[3], [2], [1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[99], [8], [100]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[112], [113], [114]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[115]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[116], [8], [117]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[116], [8], [117]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[112], [113], [114]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[115]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[56], [141], [26]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[112], [113], [114]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[112], [113], [114]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[112], [113], [114]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[112], [113], [114]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[175], [50], [176]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[50], [26], [181]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[112], [113], [114]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[112], [113], [114]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[112], [113], [114]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[112], [113], [114]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[112], [113], [114]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[112], [113], [114]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[112], [113], [114]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[115]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[115]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[112], [113], [114]
	Additive hypotensive effects					Drug Num: 59
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[26], [89], [20]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[102], [103], [104]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[102], [103], [104]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[102], [103], [104]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[102], [103], [104]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[102], [103], [104]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[102], [103], [104]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[102], [103], [104]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[102], [103], [104]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[102], [103], [104]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[102], [103], [104]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[102], [103], [104]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[102], [103], [104]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[102], [103], [104]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[102], [103], [104]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[102], [103], [104]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[102], [103], [104]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[102], [103], [104]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[102], [103], [104]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[102], [103], [104]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[102], [103], [104]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[102], [103], [104]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[102], [103], [104]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[102], [103], [104]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[102], [103], [104]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[102], [103], [104]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[102], [103], [104]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[102], [103], [104]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[102], [103], [104]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[102], [103], [104]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[102], [103], [104]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[102], [103], [104]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[102], [103], [104]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[102], [103], [104]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[102], [103], [104]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[102], [103], [104]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[102], [103], [104]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[102], [103], [104]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[102], [103], [104]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[102], [103], [104]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[102], [103], [104]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[102], [103], [104]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[102], [103], [104]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[102], [103], [104]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[102], [103], [104]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[102], [103], [104]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[102], [103], [104]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[102], [103], [104]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[102], [103], [104]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[102], [103], [104]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[102], [103], [104]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[102], [103], [104]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[102], [103], [104]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[102], [103], [104]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[102], [103], [104]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[102], [103], [104]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[102], [103], [104]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[102], [103], [104]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[102], [103], [104]
	Additive serotonergic effects					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[43], [44], [45]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[43], [44], [45]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[43], [44], [45]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[43], [44], [45]
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[43], [44], [45]
D1437		Safinamide	C17H19FN2O2	131682	Major		Inter Info	[69], [70], [71]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[43], [44], [45]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[43], [44], [45]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[105], [106], [107]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[105], [106], [107]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[105], [106], [107]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[105], [106], [107]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[105], [106], [107]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[105], [106], [107]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[105], [106], [107]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[8], [39], [202]
	Increased risk of bleeding					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[131], [132], [133]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[131], [132], [133]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[131], [132], [133]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0146		Baricitinib	C16H17N7O2S	44205240	Moderate		Inter Info	[137], [138]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[137], [138]
	Increased risk of hypoglycemia					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[93], [94], [95]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[93], [94], [95]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[93], [94], [95]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[93], [94], [95]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[178], [179], [180]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[178], [179], [180]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[178], [179], [180]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[178], [179], [180]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[178], [179], [180]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[93], [94], [95]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[93], [94], [95]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[93], [94], [95]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[93], [94], [95]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[93], [94], [95]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[178], [179], [180]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[178], [179], [180]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[178], [179], [180]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[178], [179], [180]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[178], [179], [180]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[178], [179], [180]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[178], [179], [180]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[178], [179], [180]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[178], [179], [180]
	Increased risk of hyponatremia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[120], [121], [122]
	Increased risk of lowers seizure threshold					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[40], [41], [42]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[40], [41], [42]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[8], [53], [130]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[169], [170], [171]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[199], [200], [201]
	Increased risk of prolong QT interval					Drug Num: 114
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[7], [8], [9]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[13], [14], [15]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[18], [7], [19]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[18], [22], [23]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[24]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[18], [22], [23]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[8], [25], [26]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[7], [8], [27]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[26], [28]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[7], [8], [29]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[18], [7], [30]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[36], [18], [37]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[7], [38], [39]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[13], [14], [15]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[26], [48]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[26], [49], [50]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[8], [51], [52]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[7], [8], [53]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[26], [54], [50]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[7], [8], [55]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[18], [7], [8]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[26], [58], [50]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[61], [26], [50]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[62], [63], [64]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[7], [8], [65]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[8], [66], [67]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[18], [22], [23]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[18], [22], [23]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[18], [68], [52]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[7], [8], [72]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[73], [50]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[75], [76], [77]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[7], [8], [83]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[18], [7], [84]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[18], [22], [23]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[18], [7], [8]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[7], [8], [85]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[7], [8], [86]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[36], [18], [37]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[18], [22], [23]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[18], [7], [53]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[18], [7], [90]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[8], [91], [92]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[18], [101], [52]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[108], [68], [52]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[108], [68], [52]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[108], [68], [52]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[8], [91], [92]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[8], [91], [92]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[108], [68], [52]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[144], [145], [60]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[7], [151]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[108], [68], [52]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[8], [91], [92]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[108], [68], [52]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[108], [68], [52]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[155], [26]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[8], [156]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[8], [91], [92]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[18], [7], [8]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[7], [8], [157]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[108], [68], [52]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[165], [166], [167]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[168]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[173]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[8], [91], [92]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[108], [68], [52]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[8], [177], [60]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[108], [68], [52]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[108], [68], [52]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[108], [68], [52]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[108], [68], [52]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[108], [68], [52]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[8], [91], [92]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[7], [108], [186]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[7], [108], [186]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[108], [68], [52]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[108], [68], [52]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[108], [68], [52]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[26], [189], [50]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[108], [68], [52]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[108], [68], [52]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[108], [68], [52]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[108], [68], [52]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[8], [91], [92]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[108], [68], [52]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[108], [68], [52]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[108], [68], [52]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[18], [7], [194]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[108], [68], [52]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[108], [68], [52]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[18], [8], [198]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[7], [8], [52]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[108], [68], [52]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[8], [91], [92]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[108], [68], [52]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[108], [68], [52]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[108], [68], [52]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[108], [68], [52]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[8], [91], [92]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[108], [68], [52]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[8], [91], [92]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[8], [91], [92]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[108], [68], [52]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[108], [68], [52]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[108], [68], [52]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[204], [205], [60]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[108], [68], [52]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[18], [7], [8]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[108], [68], [52]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[108], [68], [52]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[108], [68], [52]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[216], [217], [218]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[18], [7], [219]
	Increased risk of ventricular arrhythmias					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[18], [7], [32]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[8], [46], [47]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[59], [60]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[7], [74], [50]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[96], [97], [98]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[134], [135], [136]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[7], [8], [140]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[7], [8], [140]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[134], [135], [136]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[7], [8], [140]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[7], [8], [140]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[134], [135], [136]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[134], [135], [136]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[7], [8], [140]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[134], [135], [136]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[7], [8], [140]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[7], [8], [140]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[7], [8], [140]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[134], [135], [136]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[134], [135], [136]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[7], [8], [140]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[18], [187], [188]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[134], [135], [136]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[18], [187], [188]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[7], [8], [140]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[134], [135], [136]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[7], [191], [192]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[134], [135], [136]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[134], [135], [136]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[134], [135], [136]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[134], [135], [136]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[134], [135], [136]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[7], [8], [140]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[7], [191], [192]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[208], [209]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[8], [154]
Pharmacodynamic antagonistic effects
	Antagonize the effect of opioid receptor agonists					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0050		Alvimopan	C25H32N2O4	5488548	Major		Inter Info	[20], [21]
D1106		Naltrexone	C20H23NO4	5360515	Major		Inter Info	[56], [26], [57]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1862		Pegvisomant	NA	NA	Moderate		Inter Info	[56], [26], [203]

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