Drug General Information (ID: DDI2V7E4U6)
Drug Name			Dextropropoxyphene		Drug Info		Saquinavir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Anti-Hiv Agents
Structure

Mechanism of Dextropropoxyphene-Saquinavir Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Dextropropoxyphene				Saquinavir
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Dextropropoxyphene and Saquinavir

Recommended Action
Management		Coadministration of ritonavir-boosted saquinavir with other drugs that can prolong the QT interval is considered contraindicated.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.