Drug General Information (ID: DDIKZ3E8B1)
Drug Name			Dextropropoxyphene		Drug Info		Mebrofenin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Diagnostic Radiopharmaceuticals
Structure

Mechanism of Dextropropoxyphene-Mebrofenin Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Dextropropoxyphene				Mebrofenin
Mechanism		Delay transit of Technetium Tc 99m mebrofenin due to opioid-induced contraction of the distal common bile duct				Technetium Tc 99m mebrofenin
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Mebrofenin by Dextropropoxyphene

Recommended Action
Management		Nonvisualization may occur in patients who have been receiving opioids prior to cholescintigraphy.

References
1	Chen CC, Holder LE, Maunoury C, Drachenberg CI "Morphine augmentation increases galllbladder visualization in patients pretreated with cholecystokinin." J Nucl Med 38 (1997): 644-7. [PMID: 9098217]
2	Flancbaum L, Choban PS, Sinha R, Jonasson O "Morphine cholescintigraphy in the evaluation of hospitalized patients with suspected acute cholecystitis." Ann Surg 220 (1994): 25-31. [PMID: 8024355]
3	Product Information. Choletec (mebrofenin). Bracco Diagnostics Inc, Princeton, NJ.