Details of Drug

Details of Drug

 Drug General Information (ID: D0395)
  Drug Name
Cyanocobalamin
  Drug Type Small molecule
  Drug Synonymous
cyanocobalamin; 68-19-9
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  Disease Class 3A00-3A9Z: Anemia
  Therapeutic Class Vitamins
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C63H88CoN14O14P
  InChI 1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1
  InChIKey FDJOLVPMNUYSCM-WZHZPDAFSA-L
  Canonical SMILES CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]
  External Link
Pubchem ID 5311498
CAS Number 68-19-9
TTD ID D0FR6I

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM005  Altered gastric pH
BM009  Altered absorption (Unspecific)
BM081  Increased risk of ventricular arrhythmias
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Cyanocobalamin
      Affected gastrointestinal absorption
   Altered gastric pH Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0337
 
Cimetidine
 
C10H16N6S
 
2756 
Minor    Inter Info   
[12], [13], [14], [15], [16]
D0458
 
Dexlansoprazole
 
C16H14F3N3O2S
 
9578005 
Minor    Inter Info   
[12], [13], [14], [15], [16]
D0603
 
Esomeprazole
 
C17H19N3O3S
 
9568614 
Minor    Inter Info   
[12], [13], [14], [15], [16]
D0636
 
Famotidine
 
C8H15N7O2S3
 
5702160 
Minor    Inter Info   
[12], [13], [14], [15], [16]
D0892
 
Lansoprazole
 
C16H14F3N3O2S
 
3883 
Minor    Inter Info   
[12], [13], [14], [15], [16]
D1151
 
Nizatidine
 
C12H21N5O2S2
 
3033637 
Minor    Inter Info   
[12], [13], [14], [15], [16]
D1179
 
Omeprazole
 
C17H19N3O3S
 
4594 
Minor    Inter Info   
[12], [13], [14], [15], [16]
D1222
 
Pantoprazole
 
C16H15F2N3O4S
 
4679 
Minor    Inter Info   
[12], [13], [14], [15], [16]
D1373
 
Rabeprazole
 
C18H21N3O3S
 
5029 
Minor    Inter Info   
[12], [13], [14], [15], [16]
D1381
 
Ranitidine
 
C13H22N4O3S
 
3001055 
Minor    Inter Info   
[12], [13], [14], [15], [16]
D1382
 
Ranitidine (bismuth citrate)
 
C13H22N4O3S
 
3001055 
Minor    Inter Info   
[13], [14], [16]
   Altered absorption (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0065
 
Aminosalicylic acid
 
C7H7NO3
 
4649 
Minor    Inter Info   
[7], [8], [9], [10], [11]
      Pharmacodynamic additive effects
   Increased risk of ventricular arrhythmias Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0107
 
Arsenic trioxide
 
As2O3
 
14888 
Moderate    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Moderate    Inter Info   
[4], [5], [6]
References
1 Product Information. Hydro-Cobex (hydroxocobalamin). Major Pharmaceuticals Inc, Rosemont, IL.
2 Product Information. Nascobol (cyanocobalamin nasal). Schwarz Pharma, Mequon, WI.
3 Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
4 Saidi P, Wallerstein RO, Aggeler PM "Effect of chloramphenicol on erythropoiesis." J Lab Clin Med 57 (1961): 247-56
5 Haile CA "Chloramphenicol toxicity." South Med J 70 (1977): 479-80
6 Scott JL, Finegold SY, Belkin GA, Lawrence JS "A controlled double-blind study of the hematologic toxicity of chloramphenicol." N Engl J Med 272 (1965): 1137-42
7 Halsted CH, McIntyre PA "Intestinal malabsorption caused by aminosalicylic acid therapy." Arch Intern Med 130 (1972): 935-9. [PMID: 5082475]
8 Heinivaara O "Malabsorption of vitamin B112 during treatment with para-aminosalicylic acid: a preliminary report." Acta Med Scand 175 (1964): 469-71. [PMID: 14149652]
9 Levine RA, "Steatorrhea induced by para-aminosalicylic acid." Ann Intern Med 68 (1968): 1265. [PMID: 4871323]
10 Palva IP, Rytkonen U, Slatulkkila M, Palva M "Drug-induced malabsorption of vitamin B12." Scand J Haematol 9 (1972): 5-7. [PMID: 5056480]
11 Product Information. Paser Granules (aminosalicylic acid). Jacobus Pharmaceutical Company, Princeton, NJ.
12 Bradford GS, Taylor CT "Omeprazole and vitamin B-12 deficiency." Ann Pharmacother 33 (1999): 641-3. [PMID: 10369631]
13 Dutta SK "Vitamin b-12 malabsorption and omeprazole therapy." J Am Coll Nutr 13 (1994): 544-5. [PMID: 7706583]
14 Lavy NW "Omeprazole and vitamin B12." Ann Intern Med 121 (1994): 74. [PMID: 8198354]
15 Marcuard SP, Albernaz L, Khazanie PG "Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin-b12)." Ann Intern Med 120 (1994): 211-5. [PMID: 8273984]
16 Salom IL, Silvis SE, Doscherholmen A "Effect of cimetidine on the absorption of vitamin B12." Scand J Gastroenterol 17 (1982): 129-31. [PMID: 7134827]