Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIMU961LT)
  Drug Name Cyanocobalamin Drug Info Ranitidine (bismuth citrate) Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Vitamins Antiulcer Agents
  Structure

 Mechanism of Cyanocobalamin-Ranitidine (bismuth citrate) Interaction (Severity Level: Minor)
     Altered gastric pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Cyanocobalamin Ranitidine (bismuth citrate)
      Mechanism Gastric pH sensitive Gastric alkalinizer
      Key Mechanism Factor 1
Factor Name Gastric pH
Factor Description The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
      Mechanism Description
  • Decreased absorption of Cyanocobalamin due to altered gastric pH caused by Ranitidine (bismuth citrate) 

References
1 Dutta SK "Vitamin b-12 malabsorption and omeprazole therapy." J Am Coll Nutr 13 (1994): 544-5. [PMID: 7706583]
2 Lavy NW "Omeprazole and vitamin B12." Ann Intern Med 121 (1994): 74. [PMID: 8198354]
3 Salom IL, Silvis SE, Doscherholmen A "Effect of cimetidine on the absorption of vitamin B12." Scand J Gastroenterol 17 (1982): 129-31. [PMID: 7134827]