Details of Drug

Drug General Information (ID: D0364)
Drug Name	Clopidogrel
Drug Type	Small molecule
Drug Synonymous	clopidogrel; 113665-84-2; (S)-Clopidogrel; Plavix; Clopidogrel [INN:BAN]; (+)-(S)-Clopidogrel; (+)-Clopidogrel; UNII-A74586SNO7; HSDB 7430; CLOPIDOGREL SULFATE; CHEBI:37941; GKTWGGQPFAXNFI-HNNXBMFYSA-N; A74586SNO7; CPD000550475; Zyllt; Clopidogrel (TN); SR-25990C; Plavix (TN); methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoate; Clopidogrelum; Thrombo; Clopidogrel BMS; Clopidogrel Hexal; Clopidogrel Acino; methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate; PM-103; Clopidogrel (captisol-enabled); Clopidogrel (captisol-enabled), The Medicines Co; Clopidogrel (captisol-enabled, cardiovascular disease), Cydex; Clopidogrel (captisol-enabled, cardiovascular disease), Prism Pharmaceuticals Click to Show/Hide
Disease Class	DB61-GB90: Thrombosis
Therapeutic Class	Antiplatelet Agents
Structure
Structure	3D Structure		2D Structure
Formula	C16H16ClNO2S
InChI	1S/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/m0/s1
InChIKey	GKTWGGQPFAXNFI-HNNXBMFYSA-N
Canonical SMILES	COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
External Link
	Pubchem ID	60606
	CAS Number	113665-84-2
	CHEBI ID	37941
	TTD ID	D0N0TZ
	VARIDT ID	DR00245

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM050 Increased risk of bleeding BM075 Increased risk of photosensitivity reactions BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Clopidogrel
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[31], [25], [122]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[31], [25], [122]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[31], [25], [122]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1183		Opium	NA	NA	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[31], [25], [122]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[44], [31], [45], [25], [122], [123], [124], [125], [126], [127], [63], [23]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 59
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[31], [33], [34], [35], [36], [37], [38]
D0947		Loperamide	C29H33ClN2O2	3955	Major		Inter Info	[48], [49], [50], [51], [52], [53]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[31], [57]
D1294		Pioglitazone	C19H20N2O3S	4829	Major		Inter Info	[59], [60], [23], [61]
D1373		Rabeprazole	C18H21N3O3S	5029	Major		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D1392		Repaglinide	C27H36N2O4	65981	Major		Inter Info	[89], [90], [61]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[94]
D0603		Esomeprazole	C17H19N3O3S	9568614	Major		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[64], [67], [68], [69], [96], [70], [71], [72], [73], [74], [75], [76], [81], [82], [83], [84]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[64], [67], [68], [69], [96], [70], [71], [72], [73], [74], [75], [76], [81], [82], [83], [84]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[64], [67], [68], [69], [96], [70], [71], [72], [73], [74], [75], [76], [81], [82], [83], [84]
D1179		Omeprazole	C17H19N3O3S	4594	Major		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[31], [33], [34], [35], [36], [37], [38]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[64], [67], [68], [69], [96], [70], [71], [72], [73], [74], [75], [76], [81], [82], [83], [84]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[121]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[31]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[119], [120], [23]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[31], [45], [25], [179], [180], [181], [182], [183], [184], [185], [186]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[169], [171]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[191]
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[192]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[193]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[31]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[231]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[236], [237], [31], [238], [239], [240], [241], [242]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[236], [237], [31]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[31], [25], [23], [244]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[169], [171]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[169], [171]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[64], [65], [66], [67], [70], [71], [72], [73], [74], [75], [76], [79], [82], [83], [84], [85]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[64], [65], [66], [67], [70], [71], [72], [73], [74], [75], [76], [80], [82], [83], [84], [85]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[64], [67], [68], [69], [70], [71], [72], [73], [74], [75], [119], [76], [120], [78], [23], [81], [82], [83], [84]
D0686		Fluvastatin	C24H26FNO4	446155	Minor		Inter Info	[23]
D0697		Fosphenytoin	C16H15N2O6P	56339	Minor		Inter Info	[23]
D1603		Tolbutamide	C12H18N2O3S	5505	Minor		Inter Info	[23]
D0727		Glimepiride	C24H34N4O5S	3476	Minor		Inter Info	[23]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[23]
D1533		Tamoxifen	C26H29NO	2733526	Minor		Inter Info	[23]
D1611		Torasemide	C16H20N4O3S	41781	Minor		Inter Info	[275], [23]
D1714		Zafirlukast	C31H33N3O6S	5717	Minor		Inter Info	[23]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[31], [25], [171]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Minor		Inter Info	[77]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 124
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[12], [13], [14]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[15]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[25], [26]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[25], [27]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[28]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[31], [25], [32]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0415		Danaparoid	NA	NA	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[39]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[40], [41]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[25], [42]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[43]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[44], [45], [25], [46]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[25], [40], [47]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[54], [55]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[40], [56]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[31], [25], [58]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[62]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[25], [63]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[86]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[25], [87], [88]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[91]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[92]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2], [3], [4]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[31], [25], [93]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[40]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[20], [21], [24]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[95]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2], [3], [4]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[97]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[12], [13], [14]
D1613		Tositumomab	NA	NA	Major		Inter Info	[98], [99]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[98], [99]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[100], [101], [102], [103], [104], [105], [106], [107]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[100], [101], [102], [103], [104], [105], [106], [107]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[108], [31], [25], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[13]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[128], [129], [130]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[1], [23]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[108], [31], [25], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[1], [23]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[23]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[176], [177], [178]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[108], [31], [25], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[1], [23]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[187], [188], [189]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[40], [190]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[23]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[194], [195], [196]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0711		Garlic	NA	NA	Moderate		Inter Info	[197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[202], [212], [213], [206], [209]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[214], [215], [216], [217], [199], [218], [219], [200], [202], [203], [220], [212], [221], [206], [222], [223], [224], [209], [225]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[226], [200], [202], [227], [203], [228], [206], [209], [229]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[230]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[23]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[194], [195], [196]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[23]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[23]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[23]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[23]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[23]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[176], [177], [178]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[232]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[25], [233]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[25], [234], [235]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[23]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[89], [243]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[1], [23]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[1], [23]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[23]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[245], [246], [247]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[176], [177], [178]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[25], [127]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[248]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[23]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[176], [177], [178]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[176], [177], [178]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[23]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[23]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[23]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[176], [177], [178]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[25], [234], [235]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[23]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[23]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[176], [177], [178]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[23]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[108], [31], [25], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[40], [249]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[23]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[100], [101], [102], [103], [104], [105], [106], [107]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[129]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[100], [101], [102], [103], [104], [105], [106], [107]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[23]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[23]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[194], [195], [196]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[100], [101], [102], [103], [104], [105], [106], [107]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[129]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[131], [132], [133], [134], [31], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[245], [254], [25], [255], [256], [257], [258], [202], [259], [260], [261], [262], [263], [264], [265], [246], [266], [267], [247], [268]
D0253		Capsicum	NA	NA	Minor		Inter Info	[202]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[202], [269], [206]
D0368		Clove	NA	NA	Minor		Inter Info	[202], [270], [271], [272]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[273], [202], [274]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[250], [25], [251]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[25], [29], [30]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[252], [253]

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78	Product Information. Kapidex (dexlansoprazole). Takeda Pharmaceuticals America, Lincolnshire, IL.
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80	Product Information. Protonix (pantoprazole) Wyeth-Ayerst Laboratories, Philadelphia, PA.
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91	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
92	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
93	Product Information. Kadcyla (ado-trastuzumab). Genentech, South San Francisco, CA.
94	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
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105	Product Information. Streptase (streptokinase). Astra USA, Westborough, MA.
106	Product Information. Ticlid (ticlopidine). Syntex Laboratories Inc, Palo Alto, CA.
107	Product Information. TNKase (tenecteplase) Genentech, South San Francisco, CA.
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114	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
115	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
116	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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151	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
152	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
153	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
154	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
155	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
156	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
157	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
158	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
159	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
160	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
161	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
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177	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
178	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
179	Product Information. Aplenzin (buPROPion). sanofi-aventis , Bridgewater, NJ.
180	Product Information. Contrave (buPROPion-naltrexone). Orexigen Therapeutics Inc, La Jolla, CA.
181	Product Information. Forfivo XL (buPROPion (bupropion)). Almatica Pharma Inc, Parsippany, NJ.
182	Product Information. Wellbutrin SR (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
183	Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
184	Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
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195	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
196	Product Information. Ventavis (iloprost). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
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