Details of Drug

Drug General Information (ID: D0237)
Drug Name	Calcium chloride
Drug Type	Small molecule
Drug Synonymous	Calcium Chloride 10% In Plastic Container Click to Show/Hide
Disease Class	5C64: Mineral absorption/transport disorder
Therapeutic Class	Minerals And Electrolytes
Structure
Structure	3D Structure		2D Structure
Formula	CaCl2H4O2
InChI	1S/Ca.2ClH.2H2O/h;21H;21H2/q+2;;;;/p-2
InChIKey	LLSDKQJKOVVTOJ-UHFFFAOYSA-L
Canonical SMILES	O.O.[Cl-].[Cl-].[Ca+2]
External Link
	Pubchem ID	24844
	CAS Number	10035-04-8
	TTD ID	D0XQ2X

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM014 Interference of cell/tissue uptake BM089 Antagonize the effect of antihypertensive agents BM108 Increased risk of hypercalcemia BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Calcium chloride
Affected gastrointestinal absorption
	Complex formation					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1175		Omadacycline	C29H40N4O7	54697325	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[28], [29], [30]
Pharmacodynamic additive effects
	Increased risk of hypercalcemia					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[10], [11], [12]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[10], [11], [12]
D1754		Calcitriol (topical)	C27H44O3	5280453	Moderate		Inter Info	[13], [14]
D1753		Calcipotriol (topical)	C27H40O3	5288783	Moderate		Inter Info	[13], [14]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[10], [11], [12]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[10], [11], [12]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[10], [11], [12]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[10], [11], [12]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[10], [11], [12]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[10], [11], [12]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[10], [11], [12]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[10], [11], [12]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0296		Ceftriaxone	C18H18N8O7S3	5479530	Major		Inter Info	[1], [2], [3]
D0490		Digitoxin	C41H64O13	441207	Major		Inter Info	[4], [5], [6]
D0491		Digoxin	C41H64O14	2724385	Major		Inter Info	[4], [5], [6]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[7], [8], [9]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[7], [8], [9]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[7], [8], [9]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[7], [8], [9]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[7], [8], [9]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[7], [8], [9]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[7], [8], [9]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[7], [8], [9]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[7], [8], [9]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[7], [8], [9]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[7], [8], [9]

References
1	Product Information. Rocephin (ceftriaxone). Roche Laboratories, Nutley, NJ.
2	Bradley JS, Wassel RT, Lee L, Nambiar S "Intravenous Ceftriaxone and Calcium in the Neonate: Assessing the Risk for Cardiopulmonary Adverse Events." Pediatrics (2009):. [PMID: 19289450]
3	CDER. Center for Drug Evaluation and Research. FDA. U.S. Food and Drug Admninistration "Information for health care professionals: ceftriaxone (marketed as Rocephin and its generics)."
4	Product Information. Lanoxin (digoxin). Glaxo Wellcome, Research Triangle Park, NC.
5	Product Information. PhosLo (calcium acetate) Braintree, Braintree, MA.
6	Product Information. Calcium Gluconate (calcium gluconate). Fresenius Kabi USA, LLC, Lake Zurich, IL.
7	Woie L, Storstein L "Successful treatment of suicidal verapamil poisoning with calcium gluconate." Eur Heart J 2 (1981): 239-42
8	Oszko MA, Klutman NE "Use of calcium salts during cardiopulmonary resuscitation for reversing verapamil-associated hypotension." Clin Pharm 6 (1987): 448-9
9	Lipman J, Jardine I, Roos C, Dreosti L "Intravenous calcium chloride as an antidote to verapamil-induced hypotension." Intensive Care Med 8 (1982): 55-7
10	Santos F, Smith MJ, Chan JC "Hypercalciuria associated with long-term administration of calcitriol (1,25-dihydroxyvitamin D3). Action of hydrochlorothiazide." Am J Dis Child 140 (1986): 139-42
11	Drinka PJ, Nolten WE "Hazards of treating osteoporosis and hypertension concurrently with calcium, vitamin D, and distal diuretics." J Am Geriatr Soc 32 (1984): 405-7
12	Duarte CG, Winnacker JL, Becker KL, Pace A "Thiazide-induced hypercalcemia." N Engl J Med 284 (1971): 828-30
13	Product Information. Vectical (calcitriol topical). Galderma Laboratories Inc, Cranbury, NJ.
14	Product Information. Dovonex (calcipotriene). Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.
15	Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):.
16	D'Arcy PF, McElnay JC "Drug-antacid interactions: assessment of clinical importance." Drug Intell Clin Pharm 21 (1987): 607-17. [PMID: 2886325]
17	Garty M, Hurwitz A "Effect of cimetidine and antacids on gastrointestinal absorption of tetracycline." Clin Pharmacol Ther 28 (1980): 203-7. [PMID: 7398187]
18	Gotz VP, Ryerson GG "Evaluation of tetracycline on theophylline disposition in patients with chronic obstructive airways disease." Drug Intell Clin Pharm 20 (1986): 694-6. [PMID: 3757782]
19	McCormack JP, Reid SE, Lawson LM "Theophylline toxicity induced by tetracycline." Clin Pharm 9 (1990): 546-9. [PMID: 2376112]
20	Neuvonen PJ "Interactions with the absorption of tetracyclines." Drugs 11 (1976): 45-54. [PMID: 946598]
21	Nguyen VX, Nix DE, Gillikin S, Schentag JJ "Effect of oral antacid administration on the pharmacokinetics of intravenous doxycycline." Antimicrob Agents Chemother 33 (1989): 434-6. [PMID: 2729939]
22	Product Information. Declomycin (demeclocycline). Lederle Laboratories, Wayne, NJ.
23	Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
24	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
25	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
26	Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80. [PMID: 1674242]
27	Deppermann KM, Lode H, Hoffken G, Tschink G, Kalz C, Koeppe P "Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid." Antimicrob Agents Chemother 33 (1989): 1901-7. [PMID: 2610502]
28	Cerner Multum, Inc. "Australian Product Information.".
29	Davies NT "Anti-nutrient factors affecting mineral utilization." Proc Nutr Soc 38 (1979): 121-8. [PMID: 88737]
30	Multum Information Services, Inc. Expert Review Panel.

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