Drug General Information (ID: DDI253E94J)
Drug Name			Calcium chloride		Drug Info		Strontium chloride Sr-89		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Minerals And Electrolytes				Therapeutic Radiopharmaceuticals
Structure

Mechanism of Calcium chloride-Strontium chloride Sr-89 Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Calcium chloride				Strontium chloride Sr-89
Mechanism		Reduce uptake of strontium-89 chloride by bone				Strontium-89 chloride
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Strontium chloride Sr-89 by Calcium chloride

Recommended Action
Management		Calcium-containing preparations should be withheld for 2 weeks before until 2 weeks after administration of strontium-89 chloride.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Davies NT "Anti-nutrient factors affecting mineral utilization." Proc Nutr Soc 38 (1979): 121-8. [PMID: 88737]
3	Multum Information Services, Inc. Expert Review Panel.