Details of Drug

Drug General Information (ID: D0191)
Drug Name	Blinatumomab
Drug Type	Monoclonal antibody
Drug Synonymous	AMG 103; Blincyto Click to Show/Hide
Disease Class	2A85: Mature B-cell lymphoma; 2A81: Diffuse large B-cell lymphoma
Therapeutic Class	Antineoplastics/Cd19 Monoclonal Antibodies
External Link
External Link	TTD ID	D0K4RK

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM069 Increased risk of lowers seizure threshold BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Blinatumomab
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[57]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[57]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[77], [78], [57]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[57]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[57]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[57]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[57]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[77], [78], [57]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[57]
D0544		Dyphylline	C10H14N4O4	3182	Moderate		Inter Info	[57]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[57]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[57]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[57]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[57]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[57]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[57]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[57]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[57]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[57]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[57]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[57]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[57]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[57]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[57]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[57]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[57]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[10], [11], [12]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[11], [13]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [15]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[19]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[11], [35]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[40]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[49]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[51]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[16], [54], [55]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[56]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[58], [59], [60]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[10], [11]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[86]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[86]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[88]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[89]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[11], [90]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[100]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[10], [11], [101]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[58], [59], [60]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [11], [103]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [11], [103]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[105]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[86]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[106]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[129]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[58], [59], [60]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[11], [132]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[135]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[137]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[10], [11], [138]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[11], [36], [37]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[10], [38], [39]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[50]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[10], [11], [113], [114]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[10], [11], [113], [114]
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[14]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[46]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[47]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[48]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[46]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[61], [62], [63], [10], [11], [64], [65], [66], [67], [68], [69], [70], [71]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[61], [62], [63], [10], [11], [64], [65], [66], [67], [68], [69], [70], [71]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[72]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[61], [62], [63], [10], [11], [64], [65], [66], [67], [68], [69], [70], [71]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[11], [85]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[87]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[91], [92], [93], [94]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[10], [11], [97], [98], [99]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[102]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[104]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[107], [108]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[10], [11], [109]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[91], [92], [93], [94]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[91], [92], [93], [94]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[11], [127]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[128]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[61], [62], [63], [10], [11], [64], [65], [66], [67], [68], [69], [70], [71]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[133], [134]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[11], [136]
	Increased risk of lowers seizure threshold					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[41], [42], [43], [44], [45]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[41], [42], [43], [44], [45]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[52], [33], [32], [53]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[73], [74]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[95], [96], [11]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[95], [96], [11]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[95], [11], [96]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[10], [11]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[115], [116], [117], [118], [119], [120], [121], [122]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[123], [124], [125]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[7], [8], [9]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[16], [10], [17]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[18]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[7], [8], [9]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[7], [8], [9]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[16], [75], [76]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[16], [75], [76]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[16], [75], [76]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[16], [75], [76]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[16], [75], [76]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[16], [75], [76]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[16], [75], [76]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[16], [75], [76]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[16], [75], [76]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[16], [75], [76]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[16], [75], [76]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[126]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[79], [80], [81]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[79], [80], [81]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[82], [83], [84]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[82], [83], [84]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[82], [83], [84]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[82], [83], [84]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[110], [111], [112]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[130], [131]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[110], [111], [112]

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71	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
72	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
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74	Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
75	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
76	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
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82	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
83	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
84	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
85	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
86	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
87	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
88	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
89	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
90	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
91	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
92	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
93	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
94	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
95	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
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102	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
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104	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
105	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
106	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
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108	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
109	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
110	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
111	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
112	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
113	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
114	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
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125	Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.
126	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
127	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
128	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
129	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
130	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
131	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
132	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
133	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
134	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
135	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
136	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
137	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
138	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.

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